The market research conducted by FMI suggests that the global protease market is expected to reach a valuation of USD 4.6 billion by 2033. The market is projected to grow at a CAGR of 7.8% during the forecast period of the protease industry. As of 2023, the market valuation stands at USD 2.1 billion.
Some of the factors which might support the market growth are:
The growth potential for protease enzymes in the food industry is massive. The massive demand for protease in the food industry is because of its flavor and its ability to enhance texture. Apart from that, they also aid in improving the metabolism process, improving the nutritional value and solubility of the food. Protease also assists in improving the functional quality, texture, and coagulation of food products.
Rapid urbanization is also believed to be one of the major drivers of the market. Owing to a busy lifestyle, people hardly get time to concentrate on physical exercise. This gradually leads to an increase in weight, and people start developing health complications. The consumption of protease ensures that gut health remains strong. This might increase the sales of protease during the forecast period.
From the manufacturer's point of view, the production of protease is quite an affordable process. Thus, with the surge in the awareness of protease, manufacturers can easily scale up production through resource optimization. This would reduce the demand-supply gap in the future. The application of protease in the non-food sectors like pharmaceutical and detergents is also expected to surge the market share
Moreover, protease is witnessing massive demand in the dairy products market. Protease is used to avoid the coagulation of milk. The dairy products market represents huge scope for future growth as the protease market as dairy products market is valued at USD 650 billion as of 2022.
However, the market growth might be challenged owing to the lack of availability of plant and animal proteases. Furthermore, a lack of awareness regarding the benefits offered by protease might further challenge the market growth. Moreover, the extraction of protease is a costly and time-consuming process, which is also a constraint for market growth.
North America is expected to be the largest market as per the regional analysis. Developed sectors, coupled with a large number of people suffering from stomach diseases make North America an attractive market. Apart from that, the availability of key players in the region also makes North America a huge market. Moreover, the region has been witnessing massive demand for processed food and animal feed, which makes use of protease. Currently, North America is followed by Europe.
However, Asia Pacific is expected to be the fastest-growing market during the forecast period. Rapid urbanization, coupled with changes in consumption patterns and lifestyle are expected to be the major factors surging the market growth. Apart from that, government investments that are majorly focused on physical well-being are expected to surge the market share in the region.
| Attributes | Value |
|---|---|
| Protease Market Value (2022) | USD 2 billion |
| Protease Market Value (2023) | USD 2.1 billion |
| Protease Market Forecast Value (2033) | USD 4.6 billion |
| Protease Market Expected CAGR (2023 to 2033) | 7.8% |
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The historical CAGR for the market was 6.5% and the anticipated CAGR for the market is 7.8%. This jump can be attributed to the increase in lifestyle diseases and increasing awareness about protease. The manufacturers are spending huge amounts to promote their products, which would ultimately increase the market share of protease. Moreover, technological upgrades to surge the yield is also expected to drive the market.
Meat consumers are often worried about the tenderness and quality of the meat they consume. Tenderness in meat is influenced by connective tissue, sarcomere length, and the muscle's proteolytic potential. Protease enzymes are widely used to ensure the meat is tenderized properly.
Different proteases, such as bromelain, ficin, actinidin, papain, and calpain, are commonly used in the food industry to improve meat tenderness through proteolytic destruction. As protease is vital for decomposing structural proteins in connective tissues, which reduces meat hardness, food vendors and producers are extensively using protease treatment.
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The intact proteins denatured by stomach acid and attacked by endogenous proteases in the stomach initiate a digestive process that continues in the small intestine. This eventually leads to the release and complete absorption of amino acids by the intestinal epithelia.
On the other hand, young newborns are still developing minimal stomach acid, and have little protease activity.
A variety of proteases produced by the newborn contribute to catalytic activity, helping newborns to adequately digest and absorb milk proteins.
Protein digestion, specifically, in infants has some crucial implications for baby nutrition. Infants that drink animal-derived milk are more likely to develop allergies as a result of animal contamination. As a result, producers are developing protease for infant formulas, as infants struggle to make enough protease.
For instance, Novozymes' Formea® is a Kosher/Halal-certified baby formula that is low-allergenic, neutral-tasting, and low-allergenic.
Expansion of the healthcare industry will positively affect the protease market growth because of the numerous benefits they provide. These include boosting the immune system, healing skin burns, and preventing inflammatory bowel illnesses, and stomach ulcers.
Industries, such as animal feed, where protease is used to improve the nutritional characteristics of fodder and maintain gut health, account for a significant portion of the market.
For the synthesis of many APIs, enzymes have largely replaced traditional chemical-based methods, such as the production of various semi-synthetic antibiotics. There are also effects visible in the kinetic resolution of active enantiomers of drugs, and the synthesis of enantiomerically pure forms of amino acids.
To date, the Food and Drug Administration (FDA) in the USA has approved 12 protease medicines. A number of next-generation or wholly new proteases are in clinical trials. Protease's growing popularity and acceptability in the pharmaceutical business are propelling the market forward.
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Manufacturers of enzymes like protease, lipase, and others need to comply with the regulations imposed by various governing agencies. Some of them are the Association of Manufacturers & Formulators of Enzyme Products, the Enzyme Technical Association, and the EU REACH Regulation.
The food chemicals codex requires the use of enzymes in the food business to follow certain rules. Despite the fact that industrial enzymes are subject to strict restrictions in Canada, the United Kingdom, and the European Union, there is no unified regulatory system for their use. As a result, manufacturers must adhere to strict labeling, packing, and mixing restrictions before releasing items into the market. This might challenge the wide applications of enzymes.
| Region | North America |
|---|---|
| Country | USA |
| Market Share | 5.6% |
| Region | Europe |
|---|---|
| Country | United Kingdom |
| Market Share | 9.5% |
| Region | Asia Pacific |
|---|---|
| Country | China |
| Market Share | 7.9% |
| Region | Asia Pacific |
|---|---|
| Country | Japan |
| Market Share | 7.2% |
| Region | Asia Pacific |
|---|---|
| Country | South Korea |
| Market Share | 9.1% |
Millennials are the most experimental shoppers. They are less loyal and more easily swayed by influences such as the media or recommendations from friends.
Contrary to this, older consumers are likely to try new flavors or products created by businesses they are familiar with. Not just in the USA, but throughout the world, millennials are changing the way people eat.
| Attributes | Details |
|---|---|
| USA Market Expected Size (2033) | USD 903.4 million |
| USA Market Absolute Dollar Growth (USD Million/Billion) | USD 378.6 million |
| CAGR % 2017 to 2022 | 5.1% |
They enjoy consuming natural, organic, and sustainably sourced food and have increased their reliance on protein as a result of their wellness goals. Furthermore, millennials in the USA are spending record amounts on wellness. This has led to the growth of the self-care business, which is worth USD 10 billion.
As per a survey conducted by DSM Nutritional Products AG, over the course of their lives, an American millennial spends USD 155 per month on health.
With millennials increasingly preferring natural products due to their numerous health benefits, they are altering the economy. As a result, the protease market is predicted to expand rapidly.
As per Future Market Insights, the USA protease market has captured over 86.3% across North America.
The United Kingdom bakery industry is a significant part of the United Kingdom food industry.
Proteases function as catalysts for biochemical events, improving the quality of baked goods. The protease market in the United Kingdom is predicted to increase during the forecast period, as the bakery has traditionally been an important sector in the country.
| Attributes | Details |
|---|---|
| United Kingdom Market Expected Size (2033) | USD 169.4 million |
| United Kingdom Market Absolute Dollar Growth (USD Million/Billion) | USD 101.2 million |
| CAGR % 2017 to 2022 | 7.8% |
One of the key causes driving the consumption of baked goods among consumers across the country is the growing popularity of low-carbohydrate diets. As the consumption of bakery goods rises, so will the demand for various food enzymes such as proteases, amylases, lipases, and other enzymes.
Food enzymes are available for use in a variety of baked foods, including bread, tortillas, cakes, and other sweet bakery goods. The availability of a wide selection of food enzymes, particularly for bakery products is one of the key factors for market growth. Furthermore, rising sales of baked goods are an important factor driving the demand for protease in the United Kingdom.
According to the latest report, the protease market in China was estimated to be valued at USD 136 Million in the year 2022.
Endurance athletes need energy, which they get from food. Food, on the other hand, must be digested before nutrients can be absorbed. Whey protein is the king of proteins, and athletes and fitness aficionados consume more of it to help muscles develop, define, and grow.
| Attributes | Details |
|---|---|
| China Market Expected Size (2033) | USD 337.1 million |
| China Market Absolute Dollar Growth (USD Million/Billion) | USD 180 million |
| CAGR % 2017 to 2022 | 6.5% |
Unfortunately, the digestive system finds it difficult to break down and assimilate whey, which necessitates the use of particular enzymes such as proteases.
As a result of the increasing use of protease in sports nutrition and supplements, producers are offering a variety of protease-derived supplements. Following the demand for protease-derived goods, the National Health Commission of China (NHC) approved ten new food additives in 2021.
The Japanese market is expected to be driven primarily because of the massive consumption of meat. As per the data released by Statista, the Japanese meat market was valued at 3.1 billion Japanese Yen. Protease has been in huge demand in the meat market across Japan. The ability to provide much-required tenderness has attracted the attention of a lot of stakeholders.
| Attributes | Details |
|---|---|
| Japan Market Expected Size (2033) | USD 273.9 million |
| Japan Market Absolute Dollar Growth (USD Million/Billion) | USD 137 million |
| CAGR % 2017 to 2022 | 6.4% |
Moreover, the ability to provide bioactive peptides from proteins has helped the protease market see new buyers. Apart from that, the exponential growth of the plant-based meat market in Japan is expected to have a massive impact on the market.
The South Korean market is expected to witness above-average growth during the forecast period. This is owing to the massive consumption of beverages in the region. As per the market research of FMI, the revenue generated through the beverages market in South Korea was USD 21.3 billion in 2022. The protease is used in beverages for clarification and malting, which is expected to surge the demand for protease.
| Attributes | Details |
|---|---|
| South Korea Market Expected Size (2033) | USD 264.8 million |
| South Korea Market Absolute Dollar Growth (USD Million/Billion) | USD 154.4 million |
| CAGR % 2017 to 2022 | 7.1% |
Apart from that, Japan is also one of the largest consumers of seafood in the world. This coupled with the surging number of health-conscious consumers is also expected to surge the market share during the forecast period.
| Segment | Form |
|---|---|
| Attributes | Liquid |
| CAGR % 2017 to 2022 | 7.3% |
| CAGR % 2023 to End of Forecast(2033) | 8% |
| Segment | Product Type |
|---|---|
| Attributes | Microbial |
| CAGR % 2017 to 2022 | 7% |
| CAGR % 2023 to End of Forecast(2033) | 7.8% |
The liquid form of protease is projected to hold over 66.1% of the market share in 2023. The segment is expected to reach USD 1,196 Million by 2033.
Proteins are catabolized by liquid protease through the hydrolysis of peptide bonds. Protein turnover, digestion, blood coagulation, fertilization, and cell differentiation are just a few of the physiological activities that liquid proteases help in. Growth, cell signaling, immunological response, and apoptosis are all aided by it. Moreover, liquid protease has been primarily used for treating IBS and Celiac disease.
Microbial product type accounts for more than 62.8% of the market share. The segment is expected to reach USD 2,496.59 Million by 2033.
Microbial proteases have been the most studied enzyme since the beginning of enzymology. Microbial proteases have sparked interest not just because of their critical involvement in metabolic processes, but also because of their widespread use in industry. Due to their high yield, low time consumption, low space requirement, elevated genetic manipulation, and cost-effectiveness, the proteases offered are large in microbial origin.
In terms of end-use application, bakery and confectionery are projected to hold the largest share of the protease market at 14.9% in 2022. Extensive consumption of proteases in the commercial production of bread, baked products, crackers, and waffles will drive segment growth.
Protease can be used to speed up the mixing process, reduce dough consistency, and uniformity, manage gluten strength in bread, control bread texture, and enhance flavor.
In the manufacturing of bread, fungal acid protease is utilized to alter gluten-rich mixes. When proteases are added to the mixture, it partially hydrolyzes, making it soft and easy to pull and knead. Proteases are commonly used in dough preparations as well.
Due to the impact on the gluten network or gliadin, these enzymes have a significant impact on dough rheology and bread quality. Biscuits, pastries, and cookies all are infused with proteases in production.
As protease act on wheat flour proteins by lowering gluten elasticity, they are widely adopted for the shrinkage of dough or paste after molding and sheeting. For example, hydrolysis of glutenin proteins, which are responsible for dough elasticity, improves the spread ratio of cookies significantly.
With a lot of players already operating in the protease market, start-ups work on reducing the effects of overconsumption of protease. In the same line, the new players have started developing protease inhibitors for protein isolation from cell lines, plants, tissues, and other sources.
Biopioneer has been developing superior-quality novel protease inhibitors for the isolation of different proteins. These are non-toxic in nature and can be stored at room temperature, instead of investing in cold chain logistics. The protease inhibitors remain stable up to 95oC, and these remain compatible in different buffer conditions as well. To date, the company has raised up to slightly less than USD 100,000.
The manufacturers serving the market are working on developing enzymes to improve the starch yield, cut energy costs, and reduce carbon footprints. In November 2022, Novozymes took corn separation to another level by launching Frontia. This would certainly revolutionize the food industry by allowing starch manufacturers to run their corn mills in an efficient way.
Some of the recent developments are:
The top players in the market are:
| Company | Description |
|---|---|
| Novozymes | Novozymes has been creating visionary products that can shape markets and benefit society. The bio-solutions offered by the company solve some of the planet’s biggest challenges. The purpose has always been to find biological answers for better lives in a growing world. Novozymes has been laying a lot of emphasis on partnerships, communities, and alliances as they would make a lot of difference in a world full of complex challenges. Through venture methodologies, the company has always been exploring key opportunities. |
| Advanced Enzymes Technologies Limited | Advanced Enzymes Technologies Limited has been working towards ensuring that every human being is able to utilize the power of enzymes. It is the company’s mission to see that every possible industry is able to make the best possible use of enzymes and to create and produce innovative products. The company has been striving to improve the quality of the end products, reduce energy costs and optimize the usage of raw materials. Their vision is to become a leading, respected, and preferred enzyme-based solutions provider |
| Royal DSM N.V | The strategy adopted by Royal DSM N.V. revolves around continuing evolution toward health, nutrition, and bioscience leader. The company has always been generating value for all our stakeholders. The company has been evolving as a science-based company serving in the fields of health, nutrition, and bioscience. Royal DSM N.V. has been working towards all 17 Sustainable Development Goals. The company has been delivering scalable solutions that address global megatrends. |
Other key players in the protease market are BASF SE and E.l. Du Pont de Nemours & Company.
The protease market CAGR for 2033 is 7.8%.
The market is valued at USD 2.1 billion in 2023.
The forecast market value of the market for 2033 is USD 4.6 billion.
The current trend in the market is developing novel and innovative proteases.
Novozymes, Amano Enzyme, and DuPont are key market players.
1. Executive Summary | Protease Market 2. Market Overview 3. Market Background 4. Global Market Analysis 2017 to 2022 and Forecast, 2023 to 2033 5. Global Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Form 5.1. Liquid 5.2. Powder & Granule 6. Global Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Product Type 6.1. Animal 6.1.1. Trypsin 6.1.2. Renin 6.1.3. Pepsin 6.1.4. Others 6.2. Plant 6.2.1. Papain 6.2.2. Keratinases 6.2.3. Others 6.3. Microbial 6.3.1. Alkaline 6.3.2. Acid Stable 6.3.3. Neutral 6.3.4. Others 7. Global Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By End Use Application 7.1. Dairy Products 7.2. Brewing 7.3. Meat Products and Processing 7.4. Bakery & Confectionery 7.4.1. Breads 7.4.2. Cookies & Crackers 7.4.3. Pastries 7.4.4. Waffles 7.4.5. Other Bakery & Confectionery 7.5. Baby Food/ Infant Food 7.6. Oil & Fat Processing 7.7. Starch and Grain Processing 7.8. Fruits and Vegetable Processing 7.9. Cheese Making/ Processing 7.10. Egg Products 7.11. Beverages 7.12. Dietary Supplements 8. Global Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Region 8.1. North America 8.2. Latin America 8.3. Europe 8.4. East Asia 8.5. South Asia 8.6. Oceania 8.7. Middle East and Africa (MEA) 9. North America Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 10. Latin America Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 11. Europe Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 12. East Asia Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 13. South Asia Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 14. Oceania Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 15. MEA Market Analysis 2017 to 2022 and Forecast 2023 to 2033, By Country 16. Key Countries Market Analysis 17. Market Structure Analysis 18. Competition Analysis 18.1. Novozymes A/S 18.2. Advanced Enzymes Technologies Limited 18.3. BASF SE 18.4. Royal DSM N.V. 18.5. E.l. Du Pont de Nemours & Company 18.6. Rossari Biotech Limited 18.7. AB Enzymes GmbH 18.8. Lallemand Inc. 18.9. Amano Enzymes Inc. 18.10. Biocatalysts Limited 18.11. Creative Enzymes 18.12. Nagase & Co., Ltd. 18.13. Chr Hansen Holding A/S 18.14. Jiangsu Boli Bioproducts Co. Ltd. 18.15. Kemin Industries, Inc 19. Assumptions & Acronyms Used 20. Research Methodology
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