The global Primary Sclerosing Cholangitis (PSC) market size is expected to be valued at US$ 151.07 Million in 2023. With the increasing alcohol consumption among people, the overall demand for Primary Sclerosing Cholangitis (PSC) is projected to grow at a CAGR of 7.6% between 2023 and 2033, totaling around US$ 314.26 Million by 2033.
| Data Points | Key Statistics |
|---|---|
| Primary Sclerosing Cholangitis (PSC) Market Value 2023 | US$ 151.07 Million |
| Primary Sclerosing Cholangitis (PSC) Market Projected Value (2033) | US$ 314.26 Million |
| Primary Sclerosing Cholangitis (PSC) Market CAGR (2023 to 2033) | 7.6% |
According to the analysis of Future Market Insights, the Primary Sclerosing Cholangitis (PSC) market is expected to fuel over the analysis period, attributed to the factors such as the rise in the incidences of liver diseases, as well as the rise in alcohol consumption. As per the Centers for Disease Control and Prevention, the global incidence of liver disease was 3.9 million in 2016. As per the World Health Organization (WHO), the prevalence of liver cirrhosis is increasing in European countries, due to the high consumption of alcohol. Furthermore, rising awareness programs and an upsurge in Research and Development investment for the development of new drug molecules are other factors that are expected to augment the growth of the primary sclerosing cholangitis market during the forecast period.
The rising frequency of disorders linked to PSC, such as liver cancer and inflammatory bowel disease, is another factor that is anticipated to fuel the therapeutic acceptance of effective pharmaceuticals to treat the condition, which in turn is expected to accelerate the market growth. As per the World Journal of Gastroenterology, Inflammatory bowel disease (IBD) is detected in 50-80 percent of patients with PSC, with ulcerative colitis (UC) accounting for 80-90 percent of these instances.
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The global demand for Primary Sclerosing Cholangitis (PSC) is projected to increase at a CAGR of 7.6% during the forecast period between 2023 and 2033, reaching a total of US$ 314.26 Million in 2033, according to a report from Future Market Insights (FMI). From 2018 to 2022, sales witnessed significant growth, registering a CAGR of 2.8%.
According to Future Market Insights, a market research and competitive intelligence provider, the Primary Sclerosing Cholangitis (PSC) market was valued at US$ 140.4 Million in 2022.
As per the report of NCBI, in 2018, there were approximately 0.2-1.2 million people having primary sclerosing cholangitis, in Northern European countries and North America, where the disease is most common, and almost more than half of these cases could have been avoided with the availability of proper medical treatment.
Thus, factors such as a rise in the number of cholangitis cases and an increase in product approvals by several regulatory authorities globally are projected to fuel the revenue share of the market in the forthcoming years. Hence, increasing prevalence, as well as incidence rates of liver failure, and bile cancer associated with cholangitis, is one of the major factors that are likely to escalate the demand for PSC over the forecast period.
Affordable Treatment Options to Fuel the Market Growth
Currently, a liver transplant is one of the major causes of liver transplantation in the USA and is the only known cure for primary sclerosing cholangitis. However, according to a February 2018 survey by Mayo Clinic, the disease is projected to recur in the transplanted liver in 27.2% of the patients, thereby demanding efficient as well as affordable therapeutic solutions to cater to unmet patient needs. As per the United Network for Organ Sharing (UNOS), 2018, the estimated bill charges for a liver transplant procedure are around US$ 577,100 in the USA.
Additionally, there are major risk factors associated with liver transplantation that causes the death of the patient. For instance, in May 2019, as per the data published by the National Center for Biotechnology Information, pre-transplant malignancies were identified as those malignancies known prior to the transplant and those found only on pathologic evaluation of the explant. In addition, as per the data published by Mayo Clinic in March 2022, about 75% of people who undergo liver transplants live for at least five years. This means that for every 100 people who receive a liver transplant for any reason, about 75 will live for five years and 25 will die within five years.
Hence, the requirement of providing affordable treatment, due to increasing risk factors resulting in the development of serious disorders, and high costs associated with liver transplantation are major factors that are anticipated to fuel the adoption of primary sclerosing cholangitis drugs, which in turn are likely to boost the market growth over the analysis period.
Rise in Prevalence of Liver Failure & Bile Cancer to Accelerate the Market Growth
The rising incidence of diseases associated with primary sclerosing cholangitis, including liver cancer and inflammatory bowel disease, is expected to boost the therapeutic adoption of efficient drugs to manage the condition, thus accelerating the growth of the primary sclerosing cholangitis market.
For instance, in May 2021, as per an article published by Springer Nature Limited, a diagnosis of primary sclerosing cholangitis (PSC) has been associated with the increased risk of colorectal cancer, hepatobiliary cancers, and all-cause mortality in several studies, while associations with cardiovascular disease have been inconsistent. In addition, an incidence of 0.4-0.7 cases per 100,000 in the UK, and a prevalence of 3.9-16.2 per 100,000 of liver failure were reported.
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Stringent Government Regulations to Restrain the Market Growth
The withdrawal of novel molecules from late-stage clinical trials, coupled with stringent regulations for the approval of the drugs are the major factors that are anticipated to hamper the market growth in the coming years. For instance, approval of Ursodeoxycholic acid (UDCA) by the US Food and Drug Administration (FDA) for the treatment of Primary Biliary Cholangitis (PBC) required overcoming several barriers to drug development, and these barriers continue to pose challenges for current as well as the future drug development.
As cholangitis is a rare disease, the recruitment of adequate numbers of PBC patients to power clinical trials requires many participating sites. Moreover, clinical outcomes, including liver transplantation and survival, occur at a low rate, particularly in patients with early-stage disease. Hence, the timeframe for a clinical trial to demonstrate clinical benefits is not practical, especially for therapies that may be most effective in early-stage disease. Thus, these challenges are projected to limit the market growth in the near future.
High Cost of Drug Development to Limit the Market Growth
The high cost associated with drug development is one of the major factors that is anticipated to restrain the growth of the primary sclerosing cholangitis market during the forecast period. In addition, the withdrawal of molecules from late clinical stages is another factor that will hinder market growth.
Factors such as development activities in this direction, as well as a lack of initiatives by the government to spread awareness and undertake research, will further impede market growth in the near future. Also, the lack of skilled professionals or trained expertise in this area in low-and-middle class economies will further hamper in the way of growth over the analysis period.
Increase in R&D Proficiencies in the Region to Fuel the Market Growth
The Primary Sclerosing Cholangitis (PSC) Market in North America is expected to accumulate the highest market share of 42% in 2023.
Factors such as higher healthcare spending as well as favorable reimbursement scenario are expected to fuel the regional market growth during the forecast period. In addition, a developed regulatory framework, and a rise in awareness about new treatment options are other factors driving the market growth in the region.
Other factors including the rise in the research and development proficiencies by the pharmaceutical companies, rapid adoption of new and better healthcare technologies, and prevalence of sophisticated healthcare infrastructure are also likely to stimulate the demand for primary sclerosing cholangitis drugs, which in turn will boost the revenue share of the market. Favorable reimbursement policies are also inducing the dominance of the region.
North America dominated the global primary sclerosing cholangitis market in terms of revenue share in 2019. The region is expected to continue its dominance over the forecast period. This can be attributed to a rise in awareness about PSC, the availability of effective treatment methods, and the presence of well-established healthcare facilities. In addition, the increasing prevalence of diabetes and hypertension is also anticipated to drive regional growth during the forecast period.
In 2016, there were an estimated 83,081 people living with liver and intrahepatic bile duct cancer in the USA. Thus, rising bile duct cancer is another factor that is boosting the market growth in the region. The region is expected to hold the highest CAGR of 7.5% during the forecast period.
Growing Medical Tourism Industry in the Region to Fuel the Market Growth
The Primary Sclerosing Cholangitis (PSC) Market in Asia Pacific is expected to accumulate the highest market share of 40% in 2023.
Enhanced healthcare infrastructure and reimbursement policies across emerging economies including India and China, coupled with increasing incidence rates associated with PSC are the major factors that are driving the market growth in Asia Pacific.
In addition, the surging medical tourism industry, due to its low-cost burden, and enhanced healthcare services are the other key factors that are projected to contribute to regional market demand over the analysis period. Additionally, the market is expected to be driven by factors such as rising incidences of liver diseases and disorders. The region is expected to hold the highest CAGR of 7.4% during the forecast period.
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Primary Sclerosing Cholangitis Segment to beat Competition in Untiring Market
On the basis of type, the global Primary Sclerosing Cholangitis (PSC) market is dominated by the Primary Sclerosing Cholangitis Segment, which accounts for a share of 45%. The segment is expected to hold a CAGR of 7.5% over the analysis period.
The segment’s growth is attributed to the factors such as the growing research & development activities for the treatment. Primary sclerosing cholangitis is a progressive, rare, and chronic cholestatic liver disorder that is characterized by thickening, inflammation, and fibrosis of the bile ducts. Both intra- and extra-hepatic bile ducts are affected. This generally leads to cholestasis, liver cirrhosis, and eventually liver failure.
Hospitals Segment to Drive the Primary Sclerosing Cholangitis (PSC) Market
Based on the Application, the hospital's segment is expected to witness a significant growth of 62% in 2022, and the trend is expected to continue during the forecast period, expanding at a rapid rate of 7.4% CAGR over the analysis period.
This growth is attributed to rising incidence rates of MPSC among hospitalized patients across the globe. Hospital-based clinics have been found most effective in diagnosing and treating primary sclerosing cholangitis due to their access to advanced healthcare facilities, along with experienced medical professionals, which has led them to be considered one of the best treatment centers for this disease.
Primary Sclerosing Cholangitis (PSC) Market start-up players are adopting various marketing strategies such as new product launches, geographical expansion, mergers and acquisitions, partnerships, and collaboration to identify the interest of potential patients and create a larger customer base. For instance,
Prominent players in the Primary Sclerosing Cholangitis (PSC) market are Acorda Therapeutics, Inc., Gilead Sciences, Inc., NGM Biopharmaceuticals, Inc., Intercept Pharmaceuticals, Inc., Dr. Falk Pharma GmbH, Allergan Plc., Shire Plc., Durect Corporation, Conatus Pharmaceuticals, Inc., Sirnaomics, Inc., and Shenzhen HighTide Biopharmaceutical Ltd., among others.
Recent Developments:
| Report Attribute | Details |
|---|---|
| Growth Rate | CAGR of 7.6% from 2023 to 2033 |
| Market Value in 2023 | US$ 151.07 Million |
| Market Value in 2033 | US$ 314.26 Million |
| Base Year for Estimation | 2022 |
| Historical Data | 2018 to 2022 |
| Forecast Period | 2023 to 2033 |
| Quantitative Units | Revenue in US$ Million and CAGR from 2023 to 2033 |
| Report Coverage | Revenue Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends, and Pricing Analysis |
| Segments Covered |
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| Regions Covered |
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| Key Countries Profiled |
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| Key Companies Profiled |
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As of 2022, the market for Primary Sclerosing Cholangitis (PSC) was valued at US$ 140.4 Million, as per FMI.
By 2023-end, sales of Primary Sclerosing Cholangitis (PSC) closed at a value of US$ 151.07 Million.
From 2018 to 2022, Primary Sclerosing Cholangitis (PSC) demand expanded at a CAGR of 2.8%
From 2023 to 2033, Primary Sclerosing Cholangitis (PSC) sales are expected to flourish at a CAGR of 7.6%
By 2033, the market value of Primary Sclerosing Cholangitis (PSC) is expected to reach US$ 314.26 Million.
By Type, the Primary Sclerosing Cholangitis segment constitutes the bulk of market share of 45% in 2022.
By Application, the Hospitals segment dominates the market with a share of 62% in 2022.
1. Executive Summary | Primary Sclerosing Cholangitis (PSC) Market
1.1. Global Market Outlook
1.2. Demand-side Trends
1.3. Supply-side Trends
1.4. Technology Roadmap Analysis
1.5. Analysis and Recommendations
2. Market Overview
2.1. Market Coverage / Taxonomy
2.2. Market Definition / Scope / Limitations
3. Market Background
3.1. Market Dynamics
3.1.1. Drivers
3.1.2. Restraints
3.1.3. Opportunity
3.1.4. Trends
3.2. Scenario Forecast
3.2.1. Demand in Optimistic Scenario
3.2.2. Demand in Likely Scenario
3.2.3. Demand in Conservative Scenario
3.3. Opportunity Map Analysis
3.4. Product Life Cycle Analysis
3.5. Investment Feasibility Matrix
3.6. PESTLE and Porter’s Analysis
3.7. Regulatory Landscape
3.7.1. By Key Regions
3.7.2. By Key Countries
3.8. Regional Parent Market Outlook
4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033
4.1. Historical Market Size Value (US$ Million) Analysis, 2018 to 2022
4.2. Current and Future Market Size Value (US$ Million) Projections, 2023 to 2033
4.2.1. Y-o-Y Growth Trend Analysis
4.2.2. Absolute $ Opportunity Analysis
5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Drug
5.1. Introduction / Key Findings
5.2. Historical Market Size Value (US$ Million) Analysis By Drug, 2018 to 2022
5.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Drug, 2023 to 2033
5.3.1. BTT1023
5.3.2. GS-9674
5.3.3. NGM282
5.3.4. OCA
5.3.5. Cenicriviroc
5.3.6. LUM001
5.3.7. DUR928
5.3.8. norUDCA
5.3.9. HTD1801
5.3.10. IDN-7314
5.3.11. STP705
5.4. Y-o-Y Growth Trend Analysis By Drug, 2018 to 2022
5.5. Absolute $ Opportunity Analysis By Drug, 2023 to 2033
6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region
6.1. Introduction
6.2. Historical Market Size Value (US$ Million) Analysis By Region, 2018 to 2022
6.3. Current Market Size Value (US$ Million) Analysis and Forecast By Region, 2023 to 2033
6.3.1. North America
6.3.2. Latin America
6.3.3. Europe
6.3.4. Asia Pacific
6.3.5. Middle East and Africa
6.4. Market Attractiveness Analysis By Region
7. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
7.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
7.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
7.2.1. By Country
7.2.1.1. United States of America
7.2.1.2. Canada
7.2.2. By Drug
7.3. Market Attractiveness Analysis
7.3.1. By Country
7.3.2. By Drug
7.4. Key Takeaways
8. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
8.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
8.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
8.2.1. By Country
8.2.1.1. Brazil
8.2.1.2. Mexico
8.2.1.3. Rest of Latin America
8.2.2. By Drug
8.3. Market Attractiveness Analysis
8.3.1. By Country
8.3.2. By Drug
8.4. Key Takeaways
9. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
9.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
9.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
9.2.1. By Country
9.2.1.1. Germany
9.2.1.2. United Kingdom
9.2.1.3. France
9.2.1.4. Spain
9.2.1.5. Italy
9.2.1.6. Russia
9.2.1.7. Rest of Europe
9.2.2. By Drug
9.3. Market Attractiveness Analysis
9.3.1. By Country
9.3.2. By Drug
9.4. Key Takeaways
10. Asia Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
10.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
10.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
10.2.1. By Country
10.2.1.1. China
10.2.1.2. Japan
10.2.1.3. India
10.2.1.4. South Korea
10.2.1.5. Australia
10.2.1.6. Rest of APAC
10.2.2. By Drug
10.3. Market Attractiveness Analysis
10.3.1. By Country
10.3.2. By Drug
10.4. Key Takeaways
11. Middle East and Africa Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
11.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
11.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
11.2.1. By Country
11.2.1.1. South Africa
11.2.1.2. Saudi Arabia
11.2.1.3. UAE
11.2.1.4. Israel
11.2.1.5. Rest of MEA
11.2.2. By Drug
11.3. Market Attractiveness Analysis
11.3.1. By Country
11.3.2. By Drug
11.4. Key Takeaways
12. Key Countries Market Analysis
12.1. United States of America
12.1.1. Pricing Analysis
12.1.2. Market Share Analysis, 2022
12.1.2.1. By Drug
12.2. Canada
12.2.1. Pricing Analysis
12.2.2. Market Share Analysis, 2022
12.2.2.1. By Drug
12.3. Brazil
12.3.1. Pricing Analysis
12.3.2. Market Share Analysis, 2022
12.3.2.1. By Drug
12.4. Mexico
12.4.1. Pricing Analysis
12.4.2. Market Share Analysis, 2022
12.4.2.1. By Drug
12.5. Germany
12.5.1. Pricing Analysis
12.5.2. Market Share Analysis, 2022
12.5.2.1. By Drug
12.6. United Kingdom
12.6.1. Pricing Analysis
12.6.2. Market Share Analysis, 2022
12.6.2.1. By Drug
12.7. France
12.7.1. Pricing Analysis
12.7.2. Market Share Analysis, 2022
12.7.2.1. By Drug
12.8. Spain
12.8.1. Pricing Analysis
12.8.2. Market Share Analysis, 2022
12.8.2.1. By Drug
12.9. Italy
12.9.1. Pricing Analysis
12.9.2. Market Share Analysis, 2022
12.9.2.1. By Drug
12.10. Russia
12.10.1. Pricing Analysis
12.10.2. Market Share Analysis, 2022
12.10.2.1. By Drug
12.11. China
12.11.1. Pricing Analysis
12.11.2. Market Share Analysis, 2022
12.11.2.1. By Drug
12.12. Japan
12.12.1. Pricing Analysis
12.12.2. Market Share Analysis, 2022
12.12.2.1. By Drug
12.13. India
12.13.1. Pricing Analysis
12.13.2. Market Share Analysis, 2022
12.13.2.1. By Drug
12.14. South Korea
12.14.1. Pricing Analysis
12.14.2. Market Share Analysis, 2022
12.14.2.1. By Drug
12.15. Australia
12.15.1. Pricing Analysis
12.15.2. Market Share Analysis, 2022
12.15.2.1. By Drug
12.16. South Africa
12.16.1. Pricing Analysis
12.16.2. Market Share Analysis, 2022
12.16.2.1. By Drug
12.17. Saudi Arabia
12.17.1. Pricing Analysis
12.17.2. Market Share Analysis, 2022
12.17.2.1. By Drug
12.18. UAE
12.18.1. Pricing Analysis
12.18.2. Market Share Analysis, 2022
12.18.2.1. By Drug
12.19. Israel
12.19.1. Pricing Analysis
12.19.2. Market Share Analysis, 2022
12.19.2.1. By Drug
13. Market Structure Analysis
13.1. Competition Dashboard
13.2. Competition Benchmarking
13.3. Market Share Analysis of Top Players
13.3.1. By Regional
13.3.2. By Drug
14. Competition Analysis
14.1. Competition Deep Dive
14.1.1. Acorda Therapeutics, Inc.
14.1.1.1. Overview
14.1.1.2. Product Portfolio
14.1.1.3. Profitability by Market Segments
14.1.1.4. Sales Footprint
14.1.1.5. Strategy Overview
14.1.1.5.1. Marketing Strategy
14.1.2. Gilead Sciences, Inc.
14.1.2.1. Overview
14.1.2.2. Product Portfolio
14.1.2.3. Profitability by Market Segments
14.1.2.4. Sales Footprint
14.1.2.5. Strategy Overview
14.1.2.5.1. Marketing Strategy
14.1.3. NGM Biopharmaceuticals, Inc.
14.1.3.1. Overview
14.1.3.2. Product Portfolio
14.1.3.3. Profitability by Market Segments
14.1.3.4. Sales Footprint
14.1.3.5. Strategy Overview
14.1.3.5.1. Marketing Strategy
14.1.4. Intercept Pharmaceuticals, Inc.
14.1.4.1. Overview
14.1.4.2. Product Portfolio
14.1.4.3. Profitability by Market Segments
14.1.4.4. Sales Footprint
14.1.4.5. Strategy Overview
14.1.4.5.1. Marketing Strategy
14.1.5. Falk Pharma GmbH
14.1.5.1. Overview
14.1.5.2. Product Portfolio
14.1.5.3. Profitability by Market Segments
14.1.5.4. Sales Footprint
14.1.5.5. Strategy Overview
14.1.5.5.1. Marketing Strategy
14.1.6. Allergan Plc.
14.1.6.1. Overview
14.1.6.2. Product Portfolio
14.1.6.3. Profitability by Market Segments
14.1.6.4. Sales Footprint
14.1.6.5. Strategy Overview
14.1.6.5.1. Marketing Strategy
14.1.7. Takeda Pharmaceutical Company
14.1.7.1. Overview
14.1.7.2. Product Portfolio
14.1.7.3. Profitability by Market Segments
14.1.7.4. Sales Footprint
14.1.7.5. Strategy Overview
14.1.7.5.1. Marketing Strategy
14.1.8. Durect Corporation
14.1.8.1. Overview
14.1.8.2. Product Portfolio
14.1.8.3. Profitability by Market Segments
14.1.8.4. Sales Footprint
14.1.8.5. Strategy Overview
14.1.8.5.1. Marketing Strategy
14.1.9. Conatus Pharmaceuticals, Inc.
14.1.9.1. Overview
14.1.9.2. Product Portfolio
14.1.9.3. Profitability by Market Segments
14.1.9.4. Sales Footprint
14.1.9.5. Strategy Overview
14.1.9.5.1. Marketing Strategy
14.1.10. Sirnaomics, Inc.
14.1.10.1. Overview
14.1.10.2. Product Portfolio
14.1.10.3. Profitability by Market Segments
14.1.10.4. Sales Footprint
14.1.10.5. Strategy Overview
14.1.10.5.1. Marketing Strategy
15. Assumptions & Acronyms Used
16. Research Methodology
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Primary Sclerosing Cholangitis (PSC) Market
