The global persistent epithelial defect management market is slated to reach a valuation of USD 8.5 billion in 2023. According to Future Market Insights, the market is expected to grow at an 18% CAGR until 2033, being valued at USD 44.49 billion.
The persistent epithelial defect (PED) market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted PED symptoms market size from 2018 to 2030 segmented by seven major markets. The report also covers current Persistent Epithelial Defect (PED) symptoms treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Persistent epithelial defects (PEDs) result from the failure of rapid re-epithelialization and closure within 10-14 days after a corneal injury, even with standard supportive treatment. In recent years, PED awareness has increased with increased research activities from various spectrums of ophthalmology research. However, the actual frequency of PED is not known as of now, but some studies have estimated the frequency based on the causative occurrence of the disease with underlying conditions.
Some of the symptoms of PEDs are loss of corneal epithelial cells, delayed epithelialization post-injury, nonhealing epithelial defect, and others which can be commonly due to Epithelial/limbal, inflammatory disease, Neurotrophic, mechanical causes, and others.
The multi-layered corneal epithelium acts as a protective barrier to infectious agents via tight junctions between neighboring cells, and it maintains its smooth optical surface by constantly regenerating cells in the basal cell layer. Disruptions in this protective layer can render the eye susceptible to infection, stromal ulceration, perforation, scarring, and decreased visual acuity.
It covers the details of conventional and current medical therapies and diagnoses available in the persistent epithelial defect (PED) market to treat the condition. It also provides country-wise treatment guidelines and algorithms across the United States, Europe, and Japan.
The Persistent Epithelial Defect (PED) market report gives a thorough understanding of PED symptoms by including disease definition, symptoms, causes, pathophysiology, and diagnosis. It also provides PED symptoms of treatment algorithms and treatment guidelines for PED symptoms in the US, Europe, and Japan.
| Attributes | Details |
|---|---|
| Expected Market Value (2023) | USD 8.5 billion |
| Projected Forecast Value (2033) | USD 44.49 billion |
| Global Growth Rate (2023 to 2033) | 18% |
| Forecast period | 2023 to 2033 |
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The global persistent epithelial defect management market is expected to surge at a CAGR of 18% for the forecast period compared to the historic CAGR from 2018 to 2022 of 19.3%, as per Future Market Insights, a provider of market research and com compared to the competitive intelligence.
Patients usually present with pain, watering, and foreign body sensation in the affected eye. However, these features may be absent in neurotrophic PEDs. There may be blurring of vision, redness, photophobia, pain with blinking, and eye movements. PED, if left untreated, can lead to corneal inflammation, infection, ulceration, scarring, melting, and even perforation due to disruption of the protective epithelial and stromal layers of the cornea.
A comprehensive history comprising duration, mechanism of trauma, prior treatment received and surgeries, associated ocular and systemic comorbidities, family history, and immune status will help arrive at an etiological diagnosis and allow more specific treatment. Distinguishing an epithelial defect from a PED can be done based on the time required for complete healing after an injury. An epithelial defect recovers by 7 to 10 days, while a PED will not heal even after two weeks, and such a patient is usually refractory to standard treatments and supportive care
But nowadays, a thorough examination of both the eyes, adnexa, and systemic assessment is of utmost importance to determine the etiology. Fluorescein staining is used to photograph the defect for serial monitoring and measuring the size, depth, and location of the epithelial defect using a slit lamp. Deeper PEDs take longer to absorb the fluorescein into the stroma and frequently have grayish-white edges with heaped-up epithelium.
Associated signs of infection, such as underlying haze and infiltrates and anterior chamber inflammation, must be actively sought.
There can be associated basement membrane dystrophies, nodular degeneration, dendrites, limbal stem cell deficiency, conjunctival injection, features of superior limbic keratoconjunctivitis, allergic conjunctivitis, foreign body, and concretions. It is essential to assess dry eyes using the Schirmer test and tear-film breakup time. The Rose Bengal dye stains devitalized epithelial cells, implying impaired tear function, regardless of gross tear flow.
The diagnosis of PED is primarily clinical. It can be supplemented by investigations that help to quantify the lesion and track its progress.
AS-OCT is a non-invasive definitive technique for quantifying epithelial thickness and loss over time, especially in areas of corneal thinning and scarring. Confocal microscopy is a technique that allows the imaging of thin layers of living corneal cellular structures in real time. In vivo HRT-II confocal microscopy has been designed for studying the superficial and peripheral corneal and conjunctival epithelium.
For systemic comorbidities, relevant systemic investigations must be conducted. For example, in patients with diabetes, fasting and postprandial blood sugar levels and HbA1C values are measured. Vitamin A deficiency can be confirmed by measuring serum retinol-binding protein and zinc levels.
Rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) antibody for rheumatoid arthritis, antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA) antibody for systemic lupus erythematosus (SLE), anti-Ro/SSA, and anti-La/SSB antibody for Sjogren syndrome are all autoimmune indicators.
Increased Partnerships and Collaborations
The increasing partnerships and collaborations between numerous companies boost market growth. For instance, in October 2017, Bio-Tissue entered a strategic agreement with Optima Pharmazeutische GmbH, a pharmaceutical company that offers otorhinolaryngology, ophthalmology, and pneumology products. This agreement helps the company to distribute its Natural Ocular Cleanser in Germany. Thus, all these collaborations boost the growth of the market.
Higher Demand for Hospitals
The increasing demand for hospitals surges the market grows rapidly. Most chronic disease diagnostics are majorly performed in hospitals since they are very complex and it requires technologically advanced products and thus this is boosting the market for hospital/clinical laboratories.
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Lack of skilled professionals
The lack of qualified healthcare professionals who cannot treat the patients with appropriate treatments could reduce the growth of the persistent corneal epithelial defect treatment market over a forecast period.
High Cost of Treatment
The enormous expenditure that is required for setting up these techniques hinders market growth. Numerous market players make huge investments in installing new and advanced machines to faster the process and in return, the cost is increased.
This persistent corneal epithelial defects treatment market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, the impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market.
The presence of key players and increasing initiatives are accelerating the growth
North America’s persistent epithelial defects treatment market is expected to witness significant growth during the forecast period. Although numerous therapies exist and a growing number of novel approaches are evolving, treatment of this disease can still be quite challenging.
It is necessary to treat the underlying causative condition, which includes infection, limbal stem cell deficiency, or diabetes, to facilitate wound healing. The introduction of the latest technology development which offers various therapies for treating various complications caused by the disorder and the rise in the incidence of dry eye syndrome boosts the market growth.
The market in North America was valued at USD 98.8 million in 2021. In addition to the market insights such as market value, growth rate, market segments, geographical coverage, market players, and market scenario, the market report curated by the Future Market Insights team also includes in-depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.
The persistent epithelial defects treatment market is projected to witness significant growth during the forecast period. Although several therapies exist and an increasing number of novel approaches are evolving, treatment of this disease can still be quite challenging. It is essential to treat the underlying causative condition, which includes infection, limbal stem cell deficiency, or diabetes, to facilitate wound healing.
The introduction of the latest technology development offers numerous therapies for treating several complications caused by the disorder and the increase in the incidence of market growth. The expected CAGR of the persistent epithelial defects treatment market in Europe is likely to amount to 17.8% from 2023 to 2033.
The Asia-Pacific persistent epithelial defects treatment market is projected to witness significant growth during the forecast period. Although several therapies exist and an increasing number of novel approaches are evolving, treatment of this disease can still be quite challenging. It is essential to treat the underlying causative condition, which includes infection, limbal stem cell deficiency, or diabetes, to facilitate wound healing.
The introduction of the latest technology development offers numerous therapies for treating several complications caused by the disorder and the increase in the incidence of market growth. A growth rate in the persistent epithelial defects treatment market in the forecast period 2023-2033. The expected CAGR in the Asia Pacific is expected to be around 17.7% in the mentioned forecast period.
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The epithelial/limber segment will gain the dominant market share
Over the course of the forecast period, the epithelial/limber segment of disease type is anticipated to occupy a significant share of the global persistent epithelial defect management treatment market. In 2023, this category is also anticipated to acquire revenue share.
Due to their superior therapeutic activity, the epithelial/limber segment subgroup of disease types occupies a leading position in the worldwide persistent epithelial defect market. This is so because, epithelial cell migration and corneal epithelial stem cells in the limbus are crucial to regenerate the tissue after an insult to the corneal epithelium. Therefore, limbal stem cell deficiency (LSCD) often results in the inability of epithelial regeneration, stromal melting, scarring, persistent epithelial defects, corneal conjunctivalization, and neovascularization.
One of the common causes of severe limbal stem cell deficiency is an alkali-induced chemical injury from lye, household cleaning solutions, and fertilizers. Such factors are expected to accelerate the growth prospects for persistent epithelial defect management treatment from 2023 to 2033. The way to cure epithelial/limber disease is when the limbal stem cell deficiency has not yet fully developed, it can be treated with eye drops. However, in severe cases, limbal stem cell transplantation is regarded as the best option.
The demand for hospital/clinical laboratories will be more during the forecast period.
According to a report by Future Market Insights, the hospital/clinical laboratories would grow within the anticipated time frame. This market sector is expected to hold a greater share of the worldwide market from 2023 to 2033.
Due to the growing number of people visiting hospitals for advice on treatment related to epithelial/limber disease, the hospital/clinical laboratory sector is anticipated to dominate the worldwide persistent epithelial defect management market.
As a result, individuals more pertain towards their health and well-being. Thus, the majority of consumers are expected to only buy medications from hospital pharmacies.
The persistent epithelial defects management treatment market competitive landscape provides details of competitors. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width, and breadth, and application dominance. The above data points provided are only related to the companies' focus related to the persistent corneal epithelial defects treatment market.
Some of the important developments of the key players in the market are
| Report Attribute | Details |
|---|---|
| Growth Rate | 18% CAGR |
| Base Year Estimation | 2022 |
| Market Value in 2023 | USD 8.5 billion |
| Market Value in 2033 | USD 44.49 billion |
| Historical Data | 2018 to 2022 |
| Forecast Period | 2023 to 2033 |
| Quantitative Units | USD billion for Value and CAGR from 2023 to 2033 |
| Reports Coverage | Revenue Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends, and Pricing Analysis |
| Segments Covered | Disease Type, End User, Region |
| Regions Covered | North America; Latin America; Europe; South Asia; East Asia; Oceania; Middle East & Africa |
| Key Countries Profiled | United States, Canada, Brazil, Mexico, United Kingdom, Spain, Germany, Italy, France, China, Japan, South Korea, India, Malaysia, Singapore, Thailand, South Africa, Australia, New Zealand, GCC Countries, South Africa, Israel |
| Key Companies Profiled | Dompe Farmaceutici; OcuNexus Therapeutics; Eyevance Pharmaceuticals; Noveome Biotherapeutics; RegeneRx Biopharmaceuticals; Recordati Rare Diseases; Mimetech; Johnson & Johnson Services Inc.; Bausch Health Companies Inc.; Integra Lifesciences |
| Customization Scope | Available on Request |
The market is estimated to secure a valuation of USD 8.5 billion in 2023.
The United States, Japan, and China dominate the global market.
The United States may witness significant growth in the market.
The market is forecast to register a CAGR of 18% through 2033.
The global market size will reach USD 44.49 billion by 2033.
1. Executive Summary | Persistent Epithelial Defect Management Market 2. Market Overview 3. Market Background 4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033 5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Disease Type 5.1. Epithelial/limbal 5.2. Inflammatory disease 5.3. Neurotrophic disease 5.4. Others 6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By End User 6.1. Hospital/Clinical Laboratories 6.2. Physician Offices 6.3. Reference Laboratories 6.4. Other End Users 7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region 7.1. North America 7.2. Latin America 7.3. Europe 7.4. South Asia 7.5. East Asia 7.6. Oceania 7.7. Middle East & Africa 8. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 9. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 10. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 11. South Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 12. East Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 13. Oceania Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 14. Middle East & Africa Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 15. Key Countries Market Analysis 16. Market Structure Analysis 17. Competition Analysis 17.1. Dompe Farmaceutici 17.2. OcuNexus Therapeutics 17.3. Eyevance Pharmaceuticals 17.4. Noveome Biotherapeutics 17.5. RegeneRx Biopharmaceuticals 17.6. Recordati Rare Diseases 17.7. Mimetech 17.8. Johnson & Johnson Services, Inc. 17.9. Bausch Health Companies Inc. 17.10. Integra Lifesciences 18. Assumptions & Acronyms Used 19. Research Methodology
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Persistent Epithelial Defect Management Market
