The global optic atrophy management market is expected to reach a valuation of US$ 8 billion in 2023 and is projected to exhibit a CAGR of 4.9% from 2023 to 2033. By the end of the aforementioned forecast period, the market is likely to close at US$ 15.63 billion.
An existing medical analysis in gene replacement therapy has shown a satisfactory safety record but poor durability of medicinal outcomes. The research findings are encouraging and a superior comprehension of the pathophysiology of neuropathies ought to and will facilitate the creation of prospective viable strategies for vision preservation. Therefore, it will result in high growth of the optic atrophy management market.
The progression of atrophy is incremental. According to a report published on Bookinghealth.com, the disease causes irreversible blindness in 21% of cases and disability in 68% of cases. It is estimated that 1 in 35,000 people globally suffers from optic atrophy type 1. Based on a study published by the optography organization, this disease is more prevalent in Denmark, where it impacts approximately 1 in 10,000 people.
The higher incidence of optic nerve atrophy will serve as a key driver, resulting in the growing market. The soaring healthcare spending is just another significant influence on the pace of growth of the optic nerve atrophy treatment market. Moreover, advancements in medical technology, rising activities by individuals and organizations to raise awareness, and increased federal funding will all aid the expansion of the optic nerve atrophy treatment market. Other factors including the increasing geriatric population and increased demand for effective therapies will boost the growth rate of the optic atrophy treatment market. Furthermore, rising disposable income and an increase in the incidences of diabetes, glaucoma, and brain tumors will stimulate the development of the optic nerve atrophy treatment market.
The global amebicide drugs segment is being influenced by the increasing pervasiveness of parasitic infections throughout the world. The growing number of individuals afflicted by amebic infections and the high cost of new drugs in addition to the high cost of new drugs is expected to dramatically boost this market over the next several years. The segment under the distribution channel the hospital pharmacies segment held the largest share of the market in 2021. Moreover, the same segment is expected to register the highest CAGR from 2023 to 2033.
As a result of a large number of prominent stakeholders, significant disposable income, and well-developed sophisticated healthcare in this region, North America leads the optic atrophy management market. Asia-Pacific is estimated to increase over the forecast period of 2023-2033 owing to high prevalence rates, rising medical expenditure, and increased government subsidies. The progression of atrophy is incremental. According to a report published on Bookinghealth.com, the condition causes irreversible blindness in 21% of instances and disability in 68% of cases. As a result, stem cell treatment for optic atrophy is gaining popularity in Germany, therefore, it is contributing to market expansion in Europe. Considering the aforementioned facts and figures, the market is projected to exhibit a good rate of growth.
Report Attribute | Details |
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Expected Market Value (2023) | US$ 8 Billion |
Anticipated Forecast Value (2033) | US$ 15.63 Billion |
Projected Growth Rate (2023 to 2033) | 4.9% CAGR |
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Due to the lack of these drugs in many developed nations, the popularity of optic atrophy management has introduced enormous possibilities for the producers of COVID-19 managerial drugs. As a result of the demand for COVID-19 vaccines and treatment drugs, the bio and pharmaceutical industries are predicted to expand significantly in the coming years. As a result, the worldwide market is expected to suffer significantly.
Theglobal demand for Optic Atrophy Management is projected to increase at a CAGR of 4.9% during the forecast period between 2023 and 2033, reaching a total of US$ 15.63 Billion in 2033, according to a report from Future Market Insights (FMI). From 2018 to 2022, sales witnessed significant growth, registering a CAGR of 3%.
Rise in Prevalence of Cardiac Aneurysm to Push the Market Growth
One of the crucial factors propelling the expansion of the optic atrophy management market is the higher incidence of multiple sclerosis (MS) patients. As a result, companies are boosting manufacturing capacity in order to develop products that improve patients’quality of life.
In September 2019, for instance, the Swiss multinational healthcare company Roche disclosed the findings of trials for OCREVUS, an immunosuppressive drug, to better understand its impacts on recurring and gradual MS.
Advanced Drug Design and Manufacturing Capacity to boost the Market Growth
With the aid of enhanced drugformulations, firms that sell drugs for the treatment of optic atrophy treatmenthope to minimizeprecorneal drug loss and maximizedrug delivery to the anterior cells. They are incorporating mucoadhesive formulas into the creation of new drugs in the hopes of increasing ocular penetration.
Drug-particle reduced size strategies, for instance, permit faster solubilization, increasing bioavailability and permeation. As a result, companies in the optic atrophy treatment market are increasing their advanced drug design manufacturing capacity.
High Costs to Hinder Market Growth
The high costs incurred in the study and advancement of pipeline applicants used for the diagnosis of rare conditions may stymie market growth, resulting in an increase in drug prices. This can be credited to factors like increased capital for contract research organizations(CROs) undertaking clinical studies and the risk of drug rejection during clinical testing.
North America to dominate the market
North America is expected to have the largest market share during the forecast period. In 2021, the region had the largest market share. Increasing population acknowledgment of optical neuritis and MS, an aging population, and well-established sophisticated healthcare in North America are among the variables influencing growth prospects.
According to a current article published in the Journal of Neurology, the yearly recurrence of optic neuritis in the United States is associated with 5/1,000,000, with an estimated prevalence of 115/1,000,000. Increasing awareness about the early diagnosis of optic neuritis caused by multiple sclerosis and the availability of low-cost treatment options are expected to drive the global optic atrophy management market over the forecast period.
Aging population in Europe drives the market growth
Furthermore, Europe is expected to grow significantly and become the world's second-largest market in terms of revenue in the market. Stem cell therapy is being researched extensively as an intervention for degenerative eye diseases; it intends to replace dead neurons and restore nerve components. One medical study in Switzerland illustrated stem cell therapy for nerve damage.
Clinical studies were also conducted at prestigious medical institutions in Germany, Switzerland, and Belgium. In 70-90% of scenarios, a positive therapeutic effect was noticed in the form of enhanced motor and sensory activities. As a result, the high demand for stem cell therapy in Germany is expected to fuel market growth.
Ischemic optic neuropathy is an ailment in which there is an absence of blood flow to the optic nerve, resulting in sudden visual impairment. People over the age of 50 are more likely to develop ischemic optic neuropathy. As a result, Europe's growing geriatric population is also cruising the regional market. As per Statista's 2021 data, Europe has the highest proportion of older people (19%).
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Increased prevalence of eye diseases to drive sales growth
The rise in the pervasiveness of eye disorders, as well as the rise in the aging populations, who are more likely to be affected by these eye diseases, are expected to boost demand for chloramphenicol eye drops. Furthermore, increased recognition of the significance of eye care contributes to market expansion.
Moreover, the segment's expansion is aided by the easy accessibility and affordability of lubricating eye drops, in addition to drug research and advancement in vision care products. In 2021, the specialty pharmacy segment ruled the industry with a profit share of more than 64.9%. The prominence can be credited to important players' strategic planning, for instance, the acquirement of specialty pharmacies for the delivery of their products.
Key players in the Optic Atrophy Management market are AbbVie Inc, Eli Lily Company, GlaxoSmithKline, Pfizer Inc, Teva Pharmaceuticals, F. Hoffmann-La Roche AG, Bayer AG, Sanofi A.S., Bristol-Myers Squibb and Company, Bausch Health Companies Inc. Some of the latest developments by key players are below
Report Attribute | Details |
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Market Value in 2023 | US$ 8 billion |
Market Value in 2033 | US$ 15.63 billion |
Growth Rate | CAGR of 4.9% from 2023 to 2033 |
Base Year for Estimation | 2022 |
Historical Data | 2018 to 2022 |
Forecast Period | 2023 to 2033 |
Quantitative Units | Revenue in US$ Billion and CAGR from 2023 to 2033 |
Report Coverage | Revenue Forecast, Volume Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends and Pricing Analysis |
Segments Covered |
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Regions Covered |
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Key Countries Profiled |
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Key Companies Profiled |
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Customization | Available Upon Request |
Early diagnosis of optic neuritis and low-treatment cost influence the market growth.
The United States and Germany may witness significant growth in the market.
Well-established treatments are expected to drive sales.
Aging population may drive market growth over the coming years.
The market recorded a CAGR of 3% in 2022.
1. Executive Summary 1.1. Global Market Outlook 1.2. Demand-side Trends 1.3. Supply-side Trends 1.4. Technology Roadmap Analysis 1.5. Analysis and Recommendations 2. Market Overview 2.1. Market Coverage / Taxonomy 2.2. Market Definition / Scope / Limitations 3. Market Background 3.1. Market Dynamics 3.1.1. Drivers 3.1.2. Restraints 3.1.3. Opportunity 3.1.4. Trends 3.2. Scenario Forecast 3.2.1. Demand in Optimistic Scenario 3.2.2. Demand in Likely Scenario 3.2.3. Demand in Conservative Scenario 3.3. Opportunity Map Analysis 3.4. Investment Feasibility Matrix 3.5. PESTLE and Porter’s Analysis 3.6. Regulatory Landscape 3.6.1. By Key Regions 3.6.2. By Key Countries 3.7. Regional Parent Market Outlook 4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033 4.1. Historical Market Size Value (US$ Million) Analysis, 2018 to 2022 4.2. Current and Future Market Size Value (US$ Million) Projections, 2023 to 2033 4.2.1. Y-o-Y Growth Trend Analysis 4.2.2. Absolute $ Opportunity Analysis 5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Drug Type 5.1. Introduction / Key Findings 5.2. Historical Market Size Value (US$ Million) Analysis By Drug Type, 2018 to 2022 5.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Drug Type, 2023 to 2033 5.3.1. Disulfiram 5.3.2. Amebicides 5.3.3. Ethambutol 5.3.4. Isoniazid 5.3.5. Chloramphenicol 5.3.6. Vincristine 5.3.7. Ciclosporin 5.3.8. Cimetidine 5.4. Y-o-Y Growth Trend Analysis By Drug Type, 2018 to 2022 5.5. Absolute $ Opportunity Analysis By Drug Type, 2023 to 2033 6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Route of Administration 6.1. Introduction / Key Findings 6.2. Historical Market Size Value (US$ Million) Analysis By Route of Administration, 2018 to 2022 6.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Route of Administration, 2023 to 2033 6.3.1. Oral 6.3.2. Injectable 6.4. Y-o-Y Growth Trend Analysis By Route of Administration, 2018 to 2022 6.5. Absolute $ Opportunity Analysis By Route of Administration, 2023 to 2033 7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Distribution Channel 7.1. Introduction / Key Findings 7.2. Historical Market Size Value (US$ Million) Analysis By Distribution Channel , 2018 to 2022 7.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Distribution Channel , 2023 to 2033 7.3.1. Hospital Pharmacies 7.3.2. Retail Pharmacies 7.3.3. Online Pharmacies 7.4. Y-o-Y Growth Trend Analysis By Distribution Channel , 2018 to 2022 7.5. Absolute $ Opportunity Analysis By Distribution Channel , 2023 to 2033 8. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region 8.1. Introduction 8.2. Historical Market Size Value (US$ Million) Analysis By Region, 2018 to 2022 8.3. Current Market Size Value (US$ Million) Analysis and Forecast By Region, 2023 to 2033 8.3.1. North America 8.3.2. Latin America 8.3.3. Europe 8.3.4. South Asia 8.3.5. East Asia 8.3.6. Oceania 8.3.7. MEA 8.4. Market Attractiveness Analysis By Region 9. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 9.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 9.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 9.2.1. By Country 9.2.1.1. United States 9.2.1.2. Canada 9.2.2. By Drug Type 9.2.3. By Route of Administration 9.2.4. By Distribution Channel 9.3. Market Attractiveness Analysis 9.3.1. By Country 9.3.2. By Drug Type 9.3.3. By Route of Administration 9.3.4. By Distribution Channel 9.4. Key Takeaways 10. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 10.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 10.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 10.2.1. By Country 10.2.1.1. Brazil 10.2.1.2. Mexico 10.2.1.3. Rest of Latin America 10.2.2. By Drug Type 10.2.3. By Route of Administration 10.2.4. By Distribution Channel 10.3. Market Attractiveness Analysis 10.3.1. By Country 10.3.2. By Drug Type 10.3.3. By Route of Administration 10.3.4. By Distribution Channel 10.4. Key Takeaways 11. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 11.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 11.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 11.2.1. By Country 11.2.1.1. Germany 11.2.1.2. United Kingdom. 11.2.1.3. France 11.2.1.4. Spain 11.2.1.5. Italy 11.2.1.6. Rest of Europe 11.2.2. By Drug Type 11.2.3. By Route of Administration 11.2.4. By Distribution Channel 11.3. Market Attractiveness Analysis 11.3.1. By Country 11.3.2. By Drug Type 11.3.3. By Route of Administration 11.3.4. By Distribution Channel 11.4. Key Takeaways 12. South Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 12.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 12.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 12.2.1. By Country 12.2.1.1. India 12.2.1.2. Malaysia 12.2.1.3. Singapore 12.2.1.4. Thailand 12.2.1.5. Rest of South Asia 12.2.2. By Drug Type 12.2.3. By Route of Administration 12.2.4. By Distribution Channel 12.3. Market Attractiveness Analysis 12.3.1. By Country 12.3.2. By Drug Type 12.3.3. By Route of Administration 12.3.4. By Distribution Channel 12.4. Key Takeaways 13. East Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 13.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 13.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 13.2.1. By Country 13.2.1.1. China 13.2.1.2. Japan 13.2.1.3. South Korea 13.2.2. By Drug Type 13.2.3. By Route of Administration 13.2.4. By Distribution Channel 13.3. Market Attractiveness Analysis 13.3.1. By Country 13.3.2. By Drug Type 13.3.3. By Route of Administration 13.3.4. By Distribution Channel 13.4. Key Takeaways 14. Oceania Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 14.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 14.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 14.2.1. By Country 14.2.1.1. Australia 14.2.1.2. New Zealand 14.2.2. By Drug Type 14.2.3. By Route of Administration 14.2.4. By Distribution Channel 14.3. Market Attractiveness Analysis 14.3.1. By Country 14.3.2. By Drug Type 14.3.3. By Route of Administration 14.3.4. By Distribution Channel 14.4. Key Takeaways 15. MEA Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 15.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 15.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 15.2.1. By Country 15.2.1.1. GCC Countries 15.2.1.2. South Africa 15.2.1.3. Israel 15.2.1.4. Rest of MEA 15.2.2. By Drug Type 15.2.3. By Route of Administration 15.2.4. By Distribution Channel 15.3. Market Attractiveness Analysis 15.3.1. By Country 15.3.2. By Drug Type 15.3.3. By Route of Administration 15.3.4. By Distribution Channel 15.4. Key Takeaways 16. Key Countries Market Analysis 16.1. USA 16.1.1. Pricing Analysis 16.1.2. Market Share Analysis, 2022 16.1.2.1. By Drug Type 16.1.2.2. By Route of Administration 16.1.2.3. By Distribution Channel 16.2. Canada 16.2.1. Pricing Analysis 16.2.2. Market Share Analysis, 2022 16.2.2.1. By Drug Type 16.2.2.2. By Route of Administration 16.2.2.3. By Distribution Channel 16.3. Brazil 16.3.1. Pricing Analysis 16.3.2. Market Share Analysis, 2022 16.3.2.1. By Drug Type 16.3.2.2. By Route of Administration 16.3.2.3. By Distribution Channel 16.4. Mexico 16.4.1. Pricing Analysis 16.4.2. Market Share Analysis, 2022 16.4.2.1. By Drug Type 16.4.2.2. By Route of Administration 16.4.2.3. By Distribution Channel 16.5. Germany 16.5.1. Pricing Analysis 16.5.2. Market Share Analysis, 2022 16.5.2.1. By Drug Type 16.5.2.2. By Route of Administration 16.5.2.3. By Distribution Channel 16.6. United kingdom 16.6.1. Pricing Analysis 16.6.2. Market Share Analysis, 2022 16.6.2.1. By Drug Type 16.6.2.2. By Route of Administration 16.6.2.3. By Distribution Channel 16.7. France 16.7.1. Pricing Analysis 16.7.2. Market Share Analysis, 2022 16.7.2.1. By Drug Type 16.7.2.2. By Route of Administration 16.7.2.3. By Distribution Channel 16.8. Spain 16.8.1. Pricing Analysis 16.8.2. Market Share Analysis, 2022 16.8.2.1. By Drug Type 16.8.2.2. By Route of Administration 16.8.2.3. By Distribution Channel 16.9. Italy 16.9.1. Pricing Analysis 16.9.2. Market Share Analysis, 2022 16.9.2.1. By Drug Type 16.9.2.2. By Route of Administration 16.9.2.3. By Distribution Channel 16.10. India 16.10.1. Pricing Analysis 16.10.2. Market Share Analysis, 2022 16.10.2.1. By Drug Type 16.10.2.2. By Route of Administration 16.10.2.3. By Distribution Channel 16.11. Malaysia 16.11.1. Pricing Analysis 16.11.2. Market Share Analysis, 2022 16.11.2.1. By Drug Type 16.11.2.2. By Route of Administration 16.11.2.3. By Distribution Channel 16.12. Singapore 16.12.1. Pricing Analysis 16.12.2. Market Share Analysis, 2022 16.12.2.1. By Drug Type 16.12.2.2. By Route of Administration 16.12.2.3. By Distribution Channel 16.13. Thailand 16.13.1. Pricing Analysis 16.13.2. Market Share Analysis, 2022 16.13.2.1. By Drug Type 16.13.2.2. By Route of Administration 16.13.2.3. By Distribution Channel 16.14. China 16.14.1. Pricing Analysis 16.14.2. Market Share Analysis, 2022 16.14.2.1. By Drug Type 16.14.2.2. By Route of Administration 16.14.2.3. By Distribution Channel 16.15. Japan 16.15.1. Pricing Analysis 16.15.2. Market Share Analysis, 2022 16.15.2.1. By Drug Type 16.15.2.2. By Route of Administration 16.15.2.3. By Distribution Channel 16.16. South Korea 16.16.1. Pricing Analysis 16.16.2. Market Share Analysis, 2022 16.16.2.1. By Drug Type 16.16.2.2. By Route of Administration 16.16.2.3. By Distribution Channel 16.17. Australia 16.17.1. Pricing Analysis 16.17.2. Market Share Analysis, 2022 16.17.2.1. By Drug Type 16.17.2.2. By Route of Administration 16.17.2.3. By Distribution Channel 16.18. New Zealand 16.18.1. Pricing Analysis 16.18.2. Market Share Analysis, 2022 16.18.2.1. By Drug Type 16.18.2.2. By Route of Administration 16.18.2.3. By Distribution Channel 16.19. GCC Countries 16.19.1. Pricing Analysis 16.19.2. Market Share Analysis, 2022 16.19.2.1. By Drug Type 16.19.2.2. By Route of Administration 16.19.2.3. By Distribution Channel 16.20. South Africa 16.20.1. Pricing Analysis 16.20.2. Market Share Analysis, 2022 16.20.2.1. By Drug Type 16.20.2.2. By Route of Administration 16.20.2.3. By Distribution Channel 16.21. Israel 16.21.1. Pricing Analysis 16.21.2. Market Share Analysis, 2022 16.21.2.1. By Drug Type 16.21.2.2. By Route of Administration 16.21.2.3. By Distribution Channel 17. Market Structure Analysis 17.1. Competition Dashboard 17.2. Competition Benchmarking 17.3. Market Share Analysis of Top Players 17.3.1. By Regional 17.3.2. By Drug Type 17.3.3. By Route of Administration 17.3.4. By Distribution Channel 18. Competition Analysis 18.1. Competition Deep Dive 18.1.1. AbbVie Inc. 18.1.1.1. Overview 18.1.1.2. Product Portfolio 18.1.1.3. Profitability by Market Segments 18.1.1.4. Sales Footprint 18.1.1.5. Strategy Overview 18.1.1.5.1. Marketing Strategy 18.1.2. Eli Lily Company 18.1.2.1. Overview 18.1.2.2. Product Portfolio 18.1.2.3. Profitability by Market Segments 18.1.2.4. Sales Footprint 18.1.2.5. Strategy Overview 18.1.2.5.1. Marketing Strategy 18.1.3. GlaxoSmithKline 18.1.3.1. Overview 18.1.3.2. Product Portfolio 18.1.3.3. Profitability by Market Segments 18.1.3.4. Sales Footprint 18.1.3.5. Strategy Overview 18.1.3.5.1. Marketing Strategy 18.1.4. Pfizer Inc. 18.1.4.1. Overview 18.1.4.2. Product Portfolio 18.1.4.3. Profitability by Market Segments 18.1.4.4. Sales Footprint 18.1.4.5. Strategy Overview 18.1.4.5.1. Marketing Strategy 18.1.5. Teva Pharmaceuticals 18.1.5.1. Overview 18.1.5.2. Product Portfolio 18.1.5.3. Profitability by Market Segments 18.1.5.4. Sales Footprint 18.1.5.5. Strategy Overview 18.1.5.5.1. Marketing Strategy 18.1.6. F. Hoffmann-La Roche AG 18.1.6.1. Overview 18.1.6.2. Product Portfolio 18.1.6.3. Profitability by Market Segments 18.1.6.4. Sales Footprint 18.1.6.5. Strategy Overview 18.1.6.5.1. Marketing Strategy 18.1.7. Bayer AG 18.1.7.1. Overview 18.1.7.2. Product Portfolio 18.1.7.3. Profitability by Market Segments 18.1.7.4. Sales Footprint 18.1.7.5. Strategy Overview 18.1.7.5.1. Marketing Strategy 18.1.8. Sanofi A.S. 18.1.8.1. Overview 18.1.8.2. Product Portfolio 18.1.8.3. Profitability by Market Segments 18.1.8.4. Sales Footprint 18.1.8.5. Strategy Overview 18.1.8.5.1. Marketing Strategy 18.1.9. Bristol-Myers Squibb and Company 18.1.9.1. Overview 18.1.9.2. Product Portfolio 18.1.9.3. Profitability by Market Segments 18.1.9.4. Sales Footprint 18.1.9.5. Strategy Overview 18.1.9.5.1. Marketing Strategy 18.1.10. Bausch Health Companies Inc. 18.1.10.1. Overview 18.1.10.2. Product Portfolio 18.1.10.3. Profitability by Market Segments 18.1.10.4. Sales Footprint 18.1.10.5. Strategy Overview 18.1.10.5.1. Marketing Strategy 19. Assumptions & Acronyms Used 20. Research Methodology
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