Metagenomics Market

Metagenomics Market Snapshot (2023 to 2033)

As per the recent market research conducted by FMI, the global metagenomics market is expected to advance at a CAGR of 6.9% during the forecast period. The valuation in 2023 is expected to be US$ 202.9 million. By 2033, the market value is expected to be US$ 394.2 million.

Key factors that may propel the market growth are:

• The rising use of metagenomics techniques across varied areas increased government and private sector investment in large-scale sequencing projects.
• An increase in chronic illness cases, and breakthroughs in sequencing technology.
• Rapid advances in sequencing methods have enabled humans to get a better grasp of previously undiscovered molecular genetics.
• Metagenomics is gaining popularity for large-scale genomics applications aimed at determining the taxonomic and functional makeup of microbial communities.
• The growing use of metagenomics in clinical diagnostics is propelling the metagenomics industry forward.

The COVID-19 pandemic is likely to redirect attention to the growing metagenomics business.

As per an article in Future Science, 2021, pandemic risk calculations use metagenomics to trace the molecular changes in pathogens during their emergence. This could aid in the prediction of hotspots of emergence, populations at risk, and pathogens undergoing genetic evolution. Given the foregoing, the COVID-19 pandemic is projected to have a substantial influence on the metagenomics analysis.

Collaborations between government and business entities are also expected to generate sales opportunities for metagenomics throughout the projected period. For example, in October 2021, the USA Food and Drug Administration, the National Institute of Health, and 15 commercial groups entered a strategic partnership. The idea was to discover gene therapy for 30 million Americans who suffer from uncommon diseases.

Key developments in the market include the advancement of sequencing technologies from shotgun sequencing to high-throughput, next-generation sequencing, and third-generation sequencing. These developments would provide an impetus for favorable growth opportunities for market players in the coming years.

As per the regional analysis, North America is expected to be the dominant market. The market will be driven by increased demand for metagenomic sequencing due to the existence of biotechnological firms, and the rising incidence of chronic illnesses. An increase in the number of human genome research initiatives and the adoption of improved diagnostic procedures are also expected to drive market growth.

Historical CAGR (2017 to 2022) vs Anticipated CAGR Trend Analysis

Metagenomics has been in demand owing to its ability to study every type of microorganism, regardless of whether it can be cultured or not. The ability to study prokaryotes and viruses in the environment through the analysis of their DNA makes metagenomics a powerful method. The capability to identify crucial bioactive compounds, enzymes, and antibiotics make metagenomics a highly reliable method. Owing to its increased usage the anticipated CAGR is expected to be more than the historical CAGR. The historical CAGR for the market was 6.4% and the anticipated CAGR is 6.9%.

• Short-term (2023 to 2026): Increasing the prevalence of various chronic and infectious diseases such as cancer might surge the adoption of metagenomics for the timely diagnosis of these diseases. The growing adoption of metagenomics in clinical diagnostics is providing an impetus for market growth. Metagenomics assists in disease detection in crops and livestock by exploring the interaction between plants and microbes, which might drive the growth in this niche.
• Medium-term (2026 to 2029): Rising adoption of metagenomics across diverse fields, and increasing investments by government and private agencies for large-scale sequencing projects might happen during this period. Rapid advancements in sequencing tools have allowed for a greater understanding of molecular genetics which was previously unknown to humans. Metagenomics might also gain immense traction for large-scale genomics applications to study the taxonomic and functional composition of microbial communities.
• Long-term (2029 to 2033): Growing demand for fuels and biofuels across the world is anticipated to further accelerate the market growth over the assessment period. Metagenomics might become one of the promising research tools for discovering novel enzymes to produce biofuel in an efficient way across industries.

How is Increasing Adoption of Metagenomics in Chronic Disease Diagnosis boosting Sales?

As the global burden of chronic diseases continues to rise, research is conducted to test the potentiality of metagenomics for timely diagnosis. This is anticipated to bolster the growth in the metagenomics market.

Metagenomic diagnostics help predict and manage the treatment of a plethora of diseases. It can be effectively used to discover hidden genetic features that could prove vital in various usages. Key applications are in novel enzymes, bioactive molecules, and genes with better or new biochemical functionalities.

In addition, the growing adoption of diagnostic tests based on metagenomics for the early diagnosis of genetic disorders will further expand the market.

Sabyasachi Ghosh

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Will Growing Efforts for controlling Environmental Toxicology influence Demand?

Metagenomics plays a crucial role in bioremediation, a process that uses naturally occurring or artificially introduced microorganisms to break down environmental pollutants.

Metagenomic approaches reveal useful information about the metagenome of microorganisms, which play a key role in the biogeochemical cycles. These are also used for the detoxification of environmental pollutants using culture-independent molecular techniques.

Targeted metagenomics is used to study the phylogenetic diversity and relative abundance of a particular gene in the environment. The increasing need for preventing and controlling environmental toxicity through bioremediation will therefore create growth opportunities for the market.

Country-wise Insights

Will the USA market continue witnessing high demand?

Rising prevalence of chronic diseases fueling the adoption of metagenomic sequencing

The USA is projected to dominate the North American market over the forecast period. Increasing demand for metagenomic sequencing due to the heavy presence of biotechnological companies and the rising prevalence of chronic diseases are expected to drive the market. A surge in the number of human genome research projects and the adoption of better diagnostic techniques might as well propel growth.

The USA is home to some of the leading pharmaceutical and biotech companies in the world. These companies are constantly employing techniques such as metagenomic sequencing for studying the nature and pattern of diseases as well as for developing targeted medicines.

What is the United Kingdom market outlook?

The heavy presence of end-use industries generates demand for metagenomic approaches like shotgun sequencing in the United Kingdom

The United Kingdom market is slated to grow at a robust pace over the forecast period, owing to the presence of leading end-use industries, and the growing popularity of shotgun sequencing. The high prevalence of genetic disorders and the continuous rise in genetic research projects are also expected to surge the growth.

Increasing efforts by the government and private organizations to make the United Kingdom an advanced genomic healthcare system market. The country is one of the leading players in genetics and genome sequencing and spends billions of dollars on developing new diagnostic tools and drugs for a wide range of diseases.

What is driving the China market?

Increasing investments in gene research triggering growth in China

As per FMI, China is anticipated to lead the metagenomics market across the Asia Pacific excluding the Japan region throughout the forecast period. Growth in the market is driven by increasing demand for genetic sequencing, the prevalence of infectious diseases, and increasing investments in gene research.

Rising investments in the healthcare sector by the government and other organizations are expected to fuel the growth in the market. For instance, in 2017 China launched the world’s largest human genome research project of 100,000 people to document their genetic makeup.

The growing popularity of metagenomics-based advanced gene sequencing techniques across agricultural and pharmaceutical industries is positively impacting growth.

Japan market: Driven by wildlife conservation

The Japanese market is mainly driven by a number of endangered species, some of which are the Asian leopard cat, Blakiston’s fish-owl, brown spotted catshark, etc. The zoologists and wildlife veterinarians in Japan are laying a lot of emphasis on their protection.

Metagenomics plays a key role in their conservation. The DNA sequencing technology of metagenomics allows for the identification of microbiomes among and within the hosts. Incorporating the microbial host and biogeographic variation assists in the forest corridor assessments, which helps in gaining a proper understanding of microbial pathogens. Adoption of these methods would help in protecting endangered species.

India: Massive number of diabetic patients to drive growth

India is home to numerous diabetic patients in the world. Based on a survey conducted in December 2022, there are more than 74 million adults who suffer from diabetes. This is to say that 1 in 6 adults suffer from diabetes.

The metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in type 2 diabetes. Healthcare has recently suggested a functional model for the development of autoimmunity for type 1 diabetes. These developments are expected to surge the demand for metagenomics in India.

Segmentation Insights

Why is the demand for library preparation kits rising?

Sales of library preparation kits to rise at robust pa ace as gene sequencing gains centerstage

As per FMI, sales in the library preparation kits segment accounted for a share of 42.0% in 2022.

DNA and RNA sequencing practices are gaining traction owing to their ability to provide valuable data about gene sequences in a small duration of time. The data generated through gene sequencing is then analyzed and used by clinicians, scientists, and researchers across various verticals such as agriculture, forensics, etc.

Library preparation kits provide efficient and quick extraction of gene segments which are then used for analysis. Moreover, advancements in technology are encouraging manufacturers to launch novel products that reduce error and stress while improving accuracy.

Which is the leading application of metagenomics?

Clinical diagnostics to remain a key application area for metagenomics

By application, demand in the clinical diagnostics and bioremediation segments is expected to remain high over the forecast period. During the last few decades, metagenomics has gained immense traction across the healthcare industry where it is being utilized for diagnostic procedures.

Similarly, metagenomics procedures are being adopted for reducing toxicity in the environment. The rising usage of metagenomics in clinical diagnostics and bioremediation is anticipated to boost the growth in the market during the forecast period.

Which is the dominant end-use industry in the market?

Demand for metagenomics remains high in pharmaceutical industries and academic and research Institutes

In terms of end use, pharmaceutical, and academic & research segments are likely to generate the maximum revenue through 2033.

With the rising prevalence of multiple chronic diseases, pharmaceutical companies and government health organizations are investing in the development of innovative drugs. Thus, the application of metagenomics is expected to increase over the forecast period. Similarly, various research activities are being conducted across educational institutions for studying and elucidating the genetic structure of microbial communities.

Start-ups develop Automation enabled Metagenomics Solution

The start-ups have developed metagenomic screening tools to aid bio-discovery. The platform developed by them enables the expression of genes from diverse sources. The combination of automation, computation, and high-throughput screening assists in capturing a large variety of proteins.

Metagenomi: The start-up utilizes metagenomics to discover next-generation gene-editing tools. The discovery engine developed by Metagenomi uses AI-backed cloud computing to find natural enzyme systems in microbial environments. It finds compact nucleases that enable the delivery of AAV vectors. The search solution developed by them is mainly for therapeutic solutions. In January 2023, Metagenomi closed oversubscribed Series B funding standing at US$ 275 million to lead therapeutic programs into clinical development.

Key Manufacturers sign Strategic Collaborations to Enhance Research Prowess

The key players look to form profitable strategic collaborations. This would enable them to develop a combined framework of technologies that can increase the yield and find promising drugs based on human omics insights. In October 2022, Illumina launched a strategic collaboration with AstraZeneca for accelerating drug target discovery.

Key developments in the market are:

• In November 2022, Illumina boosted its genomic innovation in the United Arab Emirates through a new state-of-the-art solutions center.
• In November 2022, PerkinElmer helped accelerate gene therapy research with industry-first ready-to-use viral vector assays.

Dominant players in the market are:

Other prominent companies profiled: are Qiagen N.V., and Thermo Fisher Scientific.

Metagenomics Market Segmentation

By Product Type:

• Library Preparation Kits
• Sample Extraction Kits
• Metagenomic Sequencing Kits

By Application:

• Microbial Diversity
• Bioremediation and Degradation
• Bio Surfactants and Antibiotics Production
• Clinical Diagnostics
• Others

By End User:

• Pharmaceutical Industries
• Research Laboratories
• Biotechnology Companies
• Pathology Laboratories
• Academic and Research Institutes

By Region:

• North America
• Latin America
• Europe
• Commonwealth of Independent States and Russia
• Japan
• Asia Pacific Excluding Japan
• The Middle East and Africa