The global hyaluronic viscosupplementation market was valued at USD 2.3 Billion in 2022 and is expected to reach USD 4.0 Billion by 2033.
The three injection knee hyaluronic acid injections with around 49.1% in terms of value share, has topped the global Market within the product category in 2022 and is expected to grow at a CAGR of close to 5.2% over the forecast period (2023 to 2033)
Market Outlook:
Data Points | Market Insights |
---|---|
Market Value 2022 | USD 2.3 Billion |
Market Value 2023 | USD 2.4 Billion |
Market Value 2033 | USD 4.0 Billion |
CAGR 2023 to 2033 | 5.2% |
Market Share of Top 5 Countries | 73.2% |
Key Market Players | Anika Therapeutics Inc.; Zimmer Biomet; Sanofi S.A.; LG Chem; Chugai Pharmaceutical Co.; Ltd.; Meiji Seika Pharma co. ltd; Ferring B.V.; Hanmi Pharm.Co.;Ltd.; Anika Therapeutics; Inc.; Fidia Farmaceutici s.p.a.; Bioventus LLC; OrthogenRx; Seikagaku Corporation; Bioiberica S.A.U.; APTISSEN; Hangzhou Singclean Medical Products Co.;Ltd; Maxigen Biotech Inc.; TRB Chemedica International SA; Yuria-Pharm LLC; Haohai Biological Technology; and Chroma Pharma |
The injection of exogenous hyaluronic acid into diarthrodial joints restores synovial fluid characteristics, generating mechanical, analgesic, anti-inflammatory, and chondroprotective benefits. Hyaluronic acid is a polymer with a high viscosity and spatial structure. Rapid rehabilitation using hyaluronic acid filler offers relief from knee osteoarthritis, benefiting rheumatologists, rehabilitation providers, and primary care providers.
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The global market for hyaluronic viscosupplementation was around 24.4% of the overall USD 9.56 Billion of the global hyaluronic acid based products market in 2022.
Knee osteoarthritis is a chronic degenerative condition that affects the structure of the joints and causes inflammation, leading to joint discomfort and functional restrictions. Significant population globally suffers from osteoarthritis, a multifactorial origin joint disease, with high prevalence in adults.
Because of its low allergic reaction rate, simplicity of injection, speedy recovery, repeatability, and quick effects, hyaluronic acid filler has gained popularity. Hyaluronic acid injections into the joints are another common procedure, particularly for individuals with osteoarthritis of the knees.
In light of doctors' general reluctance to provide repeated injection of intra-articular corticosteroid injections, hyaluronic acid injection as a non-surgical therapeutic option have gained large popularity.
Owed to the above factors, the global market is projected to grow at CAGR of 5.2% in forecasted period.
Viscosupplementation offers a structural benefit in knee osteoarthritis treatment, with improved visual appearance and increased cartilage volume. One year after treatment, joint surface reconstitutes, with reduced loss of joint space. This results in a cost-effectiveness relationship and potential delay in total knee arthroplasty.
First-line therapy for OA focuses on joint preservation and alleviating symptoms. Intra-articular hyaluronic acid injections (IAHA) are a promising nonsurgical treatment, particularly for mild-to-moderate OA and severe OA with comorbidities.
IAHA, a nonsurgical treatment modality, has gained popularity in managing knee OA, despite the lack of established disease-modifying treatments. Surgical methods for total knee replacement (TKR) are successful, although they have a risk-benefit ratio. Although intra-articular hyaluronic acid (IAHA) therapy or viscosupplementation have grown in recognition, there isn't enough solid research to back up their efficacy and safety.
IAHA gives patients with knee OA a little clinical benefit without safety issues, whereas viscosupplementation has a substantial benefit-to-risk ratio and speeds up TKR. IAHA improves knee OA by allowing lubrication, shock absorption, and re-establishing joint homeostasis through induction of endogenous HA production. It reduces analgesic usage to half and leads to a 40-month improvement in pain and joint function.
Price and synthesis of HA products vary, with some made synthetically through biotechnology, while others are derived from animals. These differences impact the healthcare system's economic impact. Stabilized hyaluronic acid, a new generation of HA preparations, offers a long half-life and high density, reducing injections and puncture risk in osteoarthritis treatment.
Viscosupplementation saves money in the long run by postponing surgery for severe pain, allowing therapeutic prosthesis installation, and enhancing the patient's quality of life.
National and international guidelines discourage intra-articular hyaluronic acid derivatives. In countries like England, viscosupplementation is given low NHS funding priority due to the Institute's recommendation. HA injections in the knees are frequently associated with poor tolerance and failure rates, with anteromedial injections exhibiting up to 30% local reaction rates.
The efficacy of viscosupplementation is being questioned, which might be attributed to improper usage or a poorly fitted patient OA profile. A qualified expert is required for HA injection, which is difficult in a non-swollen joint. Some of research published claim hyaluronic viscosupplementation to be ineffective in osteoarthritis, these factors act as restraints for demand of hyaluronic viscosupplements.
The USA occupies 50.0% of market share in 2022 globally. As per British Medical Journal (BMJ-Clinical research ed.) 2022, Medicare, and commercial insurance companies increased viscosupplementation coverage, with hyaluronic acid injections becoming first-line treatment for knee osteoarthritis.
This makes USA prominent market for hyaluronic viscosupplementation in North America.
Japan expenditure on hyaluronic viscosupplementation in 2022 was USD 198.4 Million.
OA education, weight management, self-management, and exercise are crucial for improving knee OA. However, few patients are willing to undergo surgery, especially in Japan. Surgeons may delay surgery for elderly or unwilling patients, and there is a disconnect between physicians and patients. Improved communication between physicians and patients is needed to better understand the potential benefits of surgery. This makes Japan a Lucrative market for hyaluronic viscosupplementation market.
In 2022, the China held a significant share in the East Asia market and contributed around USD 157.8 Million. China faces a significant burden of knee osteoarthritis, affecting 250 million people worldwide and causing disability.
With a large population, more patients may require rehabilitation treatment and replacement, posing a significant public health burden for China. This makes China a large market for hyaluronic viscosupplements.
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By product, three injection knee hyaluronic acid injections held 49.1% market share in world in 2022.
These injections were generally safe and showed a significant improvement in pain only at 6 months. However, more than or 5 injections were associated with a higher risk of treatment-related adverse events. Thus, demand for three injection knee hyaluronic acid injections are predicted to expand rapidly between 2023 and 2033.
Why Molecular Weight is Preferred Prominently in Hyaluronic Viscosupplementation?
The market value of high molecular weight hyaluronic viscosupplementation is USD 1.6 Billion, representing a sizable 68.8% market share in 2022. Hyaluronic acid is a high molecular weight polysaccharide used in various applications. The topic of molecular weight and hyaluronic acid's protective physicochemical functions remains controversial.
Most studies show a direct correlation between molecular weight and its effects on synoviocytes. However, some authors believe in vivo effects may differ due to excessive molecular size, preventing its ability to move from intra-articular to intercellular environments. The relationship between molecular weight and analgesia is evident in both in vitro and in vivo results, with products with molecular weight between 0.5 and 1 x 106 Da showing the best in vivo effects. Hence, high molecular weight hyaluronic viscosupplementation is preferred prominently.
By body part, the knee accounted for the prominent share in the global hyaluronic viscosupplementation market, with a revenue share of 85.2% in 2022. This segment is expected to continue holding prominent market share by the end of forecast period.
Viscosupplementation is an outpatient procedure for knees, with application method well established. Quantity and frequency depend on product characteristics and professional experience. Viscosupplementation in knee osteoarthritis has been observed to increase cartilage volume, with biopsies showing better matrix quality and increased chondrocyte density. This treatment may present a cost-effectiveness relationship, potentially reducing joint space loss.
The ambulatory surgical centers have a considerable presence in the hyaluronic viscosupplementation market, accounting for 31.7% value share in 2022, and exhibiting a high CAGR of 5.5% over the forecast period.
Pseudosepsis cases submitted to the FDA, including those involving injections of non-cross-linked hyaluronic acid, necessitate rehabilitative therapy and anti-inflammatory medications. Ambulatory surgical centers offer expert guidance and 24/7 care, benefiting end users in the hyaluronic viscosupplementation market.
Collaborations and collaborations among healthcare providers, research institutions, and technology businesses can encourage innovation and hasten hyaluronic viscosupplementation. Collaboration in research, development, and commercialization can lead to market expansion and the creation of new applications. Numerous large firms compete in the field of hyaluronic viscosupplementation. Among the well-known players in this field are:
Similarly, recent developments related to the company’s manufacturing the hyaluronic viscosupplementation injections have been tracked by the team at Future Market Insights, which are available in the full report.
Attributes | Details |
---|---|
Forecast Period | 2023 to 2033 |
Historical Data Available for | 2012 to 2022 |
Market Analysis | USD Million for Value, Units for Volume |
Key Regions Covered | North America; Latin America; Europe; South Asia; East Asia; Oceania; Middle East and Africa (MEA) |
Key Countries Covered | USA, Canada, Brazil, Mexico, Argentina, Germany, Italy, France, United Kingdom, Spain, BENELUX, Russia, Nordics, China, Japan, South Korea, India, Indonesia, Thailand, Philippines, Malaysia, Australia, New Zealand, GCC countries, Türkiye, Israel, Northern Africa and South Africa. |
Key Market Segments Covered | Product, Body Part, Molecular Weight, Indication, End User, and Region |
Key Companies Profiled | Anika Therapeutics Inc.; Zimmer Biomet; Sanofi S.A.; LG Chem; Chugai Pharmaceutical Co., Ltd.; Meiji Seika Pharma co. ltd; Ferring B.V.; Hanmi Pharm.Co.,Ltd.; Anika Therapeutics, Inc.; Fidia Farmaceutici s.p.a.; Bioventus LLC; OrthogenRx; Seikagaku Corporation; Bioiberica S.A.U.; APTISSEN; Hangzhou Singclean Medical Products Co.,Ltd; Maxigen Biotech Inc.; TRB Chemedica International SA; Yuria-Pharm LLC; Haohai Biological Technology; Chroma Pharma |
Report Coverage | Market Forecast, Competition Intelligence, DROT Analysis, Market Dynamics and Challenges, Strategic Growth Initiatives |
Pricing | Available upon Request |
The market registers USD 2.4 billion in revenue in 2023.
The global market revenue is projected to exceed USD 4.0 billion by 2033.
Sales of hyaluronic viscosupplementation is expected to record a 5.2% CAGR through 2033.
Hyaluronic viscosupplementation boasts substantial revenue prospects in Japan.
The market secured USD 2.3 billion revenue in 2022.
1. Executive Summary 2. Market Overview 3. Key Market Trends 4. Value Added Insights 5. Market Background 6. Global Market Demand Volume (Units) Analysis 2012 to 2022 and Forecast, 2023 to 2033 7. Global Market – Pricing Analysis 8. Global Market Demand (in Value or Size in USD Million) Analysis 2012 to 2022 and Forecast, 2023 to 2033 9. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, By Product 9.1. Single Injection Knee Hyaluronic Acid Injections 9.2. Three Injection Knee Hyaluronic Acid Injections 9.3. Five Injection Knee Hyaluronic Acid Injections 9.4. Next Generation (Steroid Combination) 10. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, By Body Part 10.1. Knee 10.2. Hip 10.3. Shoulder 10.4. Small Joints 10.5. Others 11. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, By Molecular Weight 11.1. High Molecular Weight 11.2. Medium Molecular Weight 11.3. Low Molecular Weight 12. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, By Indication 12.1. Knee Osteoarthritis 12.2. Tendinopathies 12.3. Shoulder Arthritis 12.4. Hip Osteoarthritis 12.5. Frozen Shoulder 12.6. Ligament Injury 12.7. Post-Arthroscopy 12.8. Others 13. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, By End User 13.1. Hospitals 13.2. Ambulatory Surgical Centers 13.3. Orthopedic Clinics 13.4. Retail Pharmacies 13.5. Online Sales 14. Global Market Analysis 2012 to 2022 and Forecast 2023 to 2033, by Region 14.1. North America 14.2. Latin America 14.3. Europe 14.4. South Asia 14.5. East Asia 14.6. Oceania 14.7. Middle East and Africa 15. North America Market Analysis 2012 to 2022 and Forecast 2023 to 2033 16. Latin America Market Analysis 2012 to 2022 and Forecast 2023 to 2033 17. Europe Market Analysis 2012 to 2022 and Forecast 2023 to 2033 18. East Asia Market Analysis 2012 to 2022 and Forecast 2023 to 2033 19. South Asia Market Analysis 2012 to 2022 and Forecast 2023 to 2033 20. Oceania Market Analysis 2012 to 2022 and Forecast 2023 to 2033 21. Middle East and Africa Market Analysis 2012 to 2022 and Forecast 2023 to 2033 22. Market Structure Analysis 23. Competition Analysis 23.1. Anika Therapeutics 23.2. Zimmer Biomet 23.3. Sanofi S.A. 23.4. LG Chem 23.5. Chugai Pharmaceutical Co., Ltd. 23.6. Meiji Seika Pharma co. ltd 23.7. Ferring B.V. 23.8. Hanmi Pharm.Co.,Ltd. 23.9. Fidia Farmaceutici s.p.a. 23.10. Bioventus LLC 23.11. OrthogenRx 23.12. Seikagaku Corporation 23.13. Bioiberica S.A.U. 23.14. APTISSEN 23.15. Hangzhou Singclean Medical Products Co.,Ltd 23.16. Maxigen Biotech Inc. 23.17. TRB Chemedica International SA 23.18. Yuria-Pharm LLC 23.19. Haohai Biological Technology 23.20. Chroma Pharma 24. Assumptions and Acronyms Used 25. Research Methodology
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