The global heterozygous familial hypercholesterolemia (HEFH) management market is expected to be worth US$ 15.11 Billion in the fiscal year 2023, which rose up from US$ 13.2 Billion in the fiscal year 2022. From 2023 to 2033, the global market is expected to grow at a 14.5% CAGR, reaching a value of US$ 58.54 Billion by the end of 2033.
Familial hypercholesterolemia (FH) is a hereditary disorder that results in high levels of low-density lipoprotein (LDL) cholesterol (also known as bad cholesterol) from birth. FH stands for familial hypercholesterolemia. FH is caused by unique DNA alterations that are handed down from one generation to the next. It is not caused by elements in one's lifestyle, including a high-fat diet or even a lack of exercise.
Without therapy, HEFH causes exceedingly high LDL as well as total cholesterol levels. Excess LDL cholesterol can clump together and create plaque in the artery walls. The plaque constricts the arteries, allowing less blood to flow through them. This is referred to as artery hardening. Whenever this happens, the heart must exert more effort to circulate blood throughout the body.
The heart can be damaged over time, resulting in heart disease. If this occurs, one of the primary symptoms is chest discomfort known as angina. This could result in a heart attack or even stroke if not treated. Thus, this disease needs to be treated at the earliest, and such reasons are why there is a surge in demand within the Heterozygous Familial Hypercholesterolemia (HEFH) management market globally.
| Data Points | Key Statistics |
|---|---|
| Anticipated Base Year Value (2022) | US$ 13.2 Billion |
| Expected Market Value (2023) | US$ 15.11 Billion |
| Projected Forecast Value (2033) | US$ 58.54 Billion |
| Global Growth Rate (2023 to 2033) | 14.5% |
| CAGR of North America (2023) | 15.3% |
| CAGR of Europe (2023 to 2033) | 14% |
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The global heterozygous familial hypercholesterolemia (HEFH) management Market grew at a CAGR of 9.2% from 2018 to 2022, as per Future Market Insights, a provider of market research and competitive intelligence. The prevalence of chronic illnesses and cardiovascular diseases, as well as an increase in the number of clinical trials along with research studies for the management of heterozygous familial hypercholesterolemia, are major drivers of the market's revenue growth. The current explosive growth of clinical medication innovation for hypercholesterolemia is another factor that is projected to fuel market revenue growth.
Due to technological advancements in the treatment of heterozygous familial hypercholesterolemia, enhanced healthcare facilities, greater research and drug development for the diagnosis, government initiatives to raise public awareness of the symptoms, causes, and therapeutic options for this type of hypercholesterolemia, as well as increased healthcare investments, it is predicted that the market will experience abundant opportunities for growth during the forecast period.
Such factors are expected to boost the global sales of Heterozygous Familial Hypercholesterolemia (HEFH) management solutions. As a result, the global Heterozygous Familial Hypercholesterolemia (HEFH) Management Market is expected to forecast a CAGR of over 14% from 2023 to 2033.
Unhealthy Lifestyles and Aging Population to Boost Demand
One of the main factors fueling the market's expansion is the increased prevalence of HEFH brought on by the general public's increasingly unhealthy lifestyle. This is supported by the growing geriatric population, which is vulnerable to cardiovascular illnesses (CVDs) and a number of other chronic diseases, including diabetes, renal troubles, and thyroid issues.
Additionally, other growth-promoting variables include the growing interest in health and the understanding of the many treatment options for HEFH management. Such factors are sure to propel the market for Heterozygous Familial Hypercholesterolemia (HEFH) management during the forecast period.
Increasing Research and Development and New Product Launches to accelerate Market Expansion
The launch of numerous medications and treatments to help hypercholesterolemia patients reach near-normal lipid profiles and lower their risk of developing CVD is giving market growth a significant boost. In addition, the creation of new medication classes with improved effectiveness and safety profiles is boosting market expansion. The introduction of numerous combination medicines to treat hypercholesterolemia that also contain other cholesterol-lowering substances is also contributing to the market's expansion.
In addition, the statins' widespread use is promoting market expansion due to their numerous benefits, including improved endothelial function, reduced oxidative stress-induced cell damage, higher atherosclerotic plaque stability, and lower inflammation. Such developments are expected to accelerate the demand for Heterozygous Familial Hypercholesterolemia (HEFH) management during the forecast period.
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Lack of Awareness and Knowledge to Impede Expansion
Both healthcare professionals and the general population are unaware of FH. As a result, it receives insufficient attention and care. Untreated HEFH patients have a 20x higher risk of developing coronary artery disease than HEFH-free individuals.
Heart attacks, stroke, and sudden cardiac death are all important cardiovascular disorders that can be brought on by coronary artery disease. However, this risk can be decreased with an early diagnosis with universal lipid screening, cascade screening in families, and effective treatment using statins and other drugs.
Rising Clinical Studies and Trials to boost Regional Demand
North America is predicted to hold the dominant market share of 41% revenue share in 2023 and is the fastest-growing market for Heterozygous Familial Hypercholesterolemia (HEFH) management, with a dominant 15.3% CAGR from 2023 to 2033. Growth can be attributed to the increasing research and developments by the key players in this region. At the same time, the huge number of clinical trials and studies being conducted on heterozygous familial hypercholesterolemia for the proper treatment are also accelerating the demand in the regional market.
For example, Ionis Pharmaceuticals, Inc., a pioneer in antisense therapeutics, and its collaborator AstraZeneca announced in 2022 that the ETESIAN Phase 2b study of ION449 (AZD8233), an investigational antisense drug intended to lower blood cholesterol levels in people with hypercholesterolemia by trying to target proprotein convertase subtilisin/kexin type 9 in mice, had shown positive results (PCSK9). The 71st Annual Scientific Session & Expo of the American College of Cardiology featured the presentation of these results.
The goal of the ETESIAN Phase 2b research was to evaluate ION449's effectiveness, safety, and tolerability in individuals with high-risk hypercholesterolemia. The study's primary goal of lowering blood LDL-C levels by up to 79% was achieved. Hence, there would be a lot of scope for North American manufacturers to develop in this market during the forecast period.
Increasing Treatment Options and Innovations to augment Treatment Incidences
During the forecast period, the European market for Heterozygous Familial Hypercholesterolemia (HEFH) management is expected to garner a steady CAGR of 14%. But at the time, the European market for the management of heterozygous familial hypercholesterolemia (HEFH) is expected to witness this market gain of 31% in 2023. Expanding research and innovations by the key players and various projects being approved for the management of Heterozygous Familial Hypercholesterolemia and increasing authorizations of the clinical trials by some prominent companies in the region are propelling the growth.
Verve Therapeutics, Inc., a clinical-stage biopharmaceutical company that is developing single-course gene editing drugs to treat cardiovascular disease, declared in 2022 that the United Kingdom's Medicines and Healthcare Products Regulatory Agency (MHRA) had approved its Clinical Trial Authorization (CTA) application for VERVE-101 as a prospective treatment for people with heterozygous familial hypercholesterolemia (HeFH). HeFH is a common hereditary variant of atherosclerotic cardiovascular disease (ASCVD) that can be fatal and is characterized by abnormally high blood levels of the disease-causing lipid LDL-cholesterol (LDL-C). Such developments are expected to accelerate the growth in the market from 2023 to 2033.
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ST-103-based Drugs to be Most Preferred Treatment Option
Over the course of the forecast period, ST-103-based drugs are anticipated to occupy a significant share of treating heterozygous familial hypercholesterolemia. In 2023, this category is anticipated to dominate with a 32% revenue share.
ST-103 is a popular statin. Since statins are advised for use in the therapy of hypercholesterolemia because of their safety and efficacy, it has been concluded that they constitute a substantial revenue generator among the market segments evaluated. Statins are the most popular treatment for hypercholesterolemia because they totally block the enzyme HMG-CoA reductase, which is in charge of producing cholesterol.
In addition, statins are engaged in lowering LDL cholesterol levels and raising HDL cholesterol levels. Such factors are expected to accelerate the growth prospects for Heterozygous Familial Hypercholesterolemia (HEFH) management from 2023 to 2033.
The start-ups strive to set their goods apart on the global market by incorporating cutting-edge technology and enhanced safety measures. The symptoms are being treated first, of course, and also various metrics are being measured to check the present condition of the patient. Some of the companies are:
Some of the prominent players in the global market for heterozygous familial hypercholesterolemia (HEFH) management are:
Some of the prominent developments of the key players in the market are:
| Report Attribute | Details |
|---|---|
| Market Value in 2023 | US$ 15.11 Billion |
| Market Value in 2033 | US$ 58.54 Billion |
| Growth Rate | CAGR of 14.5% from 2023 to 2033 |
| Base Year for Estimation | 2022 |
| Historical Data | 2018 to 2022 |
| Forecast Period | 2023 to 2033 |
| Quantitative Units | Revenue in US$ Billion and CAGR from 2023 to 2033 |
| Report Coverage | Revenue Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends, and Pricing Analysis |
| Segments Covered |
Product Type, Application, Region |
| Regions Covered |
North America; Latin America; Europe; Asia Pacific; Middle East and Africa |
| Key Countries Profiled |
USA, Canada, Brazil, Mexico, Germany, United Kingdom, France, Spain, Italy, China, Japan, South Korea, Thailand, Singapore, Indonesia, Australia, New Zealand, GCC Countries, South Africa, Israel |
| Key Companies Profiled |
Sanofi SA; Amgen Inc.; Novartis International AG; AdooQ Bioscience; Thermo Fisher Scientific; Universal Biologicals; Selleck Chemicals; Madrigal Pharmaceuticals; Shanghai Caerulum Pharma Discovery Co., Ltd.; Wuhan Biocar Pharmacy |
| Customization | Available Upon Request |
The United States generated 28% of the global demand in 2022.
The Asia Pacific market is expected to record a 9.2% CAGR through 2033.
Small molecule drugs segment contributes 72% of total production.
Oral segment holds 57% of the global market share.
From 2018 to 2022, the global market exhibited 9.2% CAGR.
1. Executive Summary | Heterozygous Familial Hypercholesterolemia (HEFH) Management Market
1.1. Global Market Outlook
1.2. Demand-side Trends
1.3. Supply-side Trends
1.4. Technology Roadmap Analysis
1.5. Analysis and Recommendations
2. Market Overview
2.1. Market Coverage / Taxonomy
2.2. Market Definition / Scope / Limitations
3. Market Background
3.1. Market Dynamics
3.1.1. Drivers
3.1.2. Restraints
3.1.3. Opportunity
3.1.4. Trends
3.2. Scenario Forecast
3.2.1. Demand in Optimistic Scenario
3.2.2. Demand in Likely Scenario
3.2.3. Demand in Conservative Scenario
3.3. Opportunity Map Analysis
3.4. Investment Feasibility Matrix
3.5. PESTLE and Porter’s Analysis
3.6. Regulatory Landscape
3.6.1. By Key Regions
3.6.2. By Key Countries
3.7. Regional Parent Market Outlook
4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033
4.1. Historical Market Size Value (US$ Million) Analysis, 2018 to 2022
4.2. Current and Future Market Size Value (US$ Million) Projections, 2023 to 2033
4.2.1. Y-o-Y Growth Trend Analysis
4.2.2. Absolute $ Opportunity Analysis
5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Product Type
5.1. Introduction / Key Findings
5.2. Historical Market Size Value (US$ Million) Analysis By Product Type, 2018 to 2022
5.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Product Type, 2023 to 2033
5.3.1. Gemcabene Calcium
5.3.2. MGL-3196
5.3.3. ST-103
5.3.4. Others
5.4. Y-o-Y Growth Trend Analysis By Product Type, 2018 to 2022
5.5. Absolute $ Opportunity Analysis By Product Type, 2023 to 2033
6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Application
6.1. Introduction / Key Findings
6.2. Historical Market Size Value (US$ Million) Analysis By Application, 2018 to 2022
6.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Application, 2023 to 2033
6.3.1. Hospitals
6.3.2. Medical Centres
6.3.3. Clinics
6.3.4. Others
6.4. Y-o-Y Growth Trend Analysis By Application, 2018 to 2022
6.5. Absolute $ Opportunity Analysis By Application, 2023 to 2033
7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region
7.1. Introduction
7.2. Historical Market Size Value (US$ Million) Analysis By Region, 2018 to 2022
7.3. Current Market Size Value (US$ Million) Analysis and Forecast By Region, 2023 to 2033
7.3.1. North America
7.3.2. Latin America
7.3.3. Europe
7.3.4. Asia Pacific
7.3.5. Middle East and Africa(MEA)
7.4. Market Attractiveness Analysis By Region
8. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
8.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
8.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
8.2.1. By Country
8.2.1.1. USA
8.2.1.2. Canada
8.2.2. By Product Type
8.2.3. By Application
8.3. Market Attractiveness Analysis
8.3.1. By Country
8.3.2. By Product Type
8.3.3. By Application
8.4. Key Takeaways
9. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
9.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
9.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
9.2.1. By Country
9.2.1.1. Brazil
9.2.1.2. Mexico
9.2.1.3. Rest of Latin America
9.2.2. By Product Type
9.2.3. By Application
9.3. Market Attractiveness Analysis
9.3.1. By Country
9.3.2. By Product Type
9.3.3. By Application
9.4. Key Takeaways
10. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
10.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
10.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
10.2.1. By Country
10.2.1.1. Germany
10.2.1.2. United Kingdom
10.2.1.3. France
10.2.1.4. Spain
10.2.1.5. Italy
10.2.1.6. Rest of Europe
10.2.2. By Product Type
10.2.3. By Application
10.3. Market Attractiveness Analysis
10.3.1. By Country
10.3.2. By Product Type
10.3.3. By Application
10.4. Key Takeaways
11. Asia Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
11.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
11.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
11.2.1. By Country
11.2.1.1. China
11.2.1.2. Japan
11.2.1.3. South Korea
11.2.1.4. Singapore
11.2.1.5. Thailand
11.2.1.6. Indonesia
11.2.1.7. Australia
11.2.1.8. New Zealand
11.2.1.9. Rest of Asia Pacific
11.2.2. By Product Type
11.2.3. By Application
11.3. Market Attractiveness Analysis
11.3.1. By Country
11.3.2. By Product Type
11.3.3. By Application
11.4. Key Takeaways
12. MEA Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
12.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
12.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
12.2.1. By Country
12.2.1.1. GCC Countries
12.2.1.2. South Africa
12.2.1.3. Israel
12.2.1.4. Rest of Middle East and Africa(MEA)
12.2.2. By Product Type
12.2.3. By Application
12.3. Market Attractiveness Analysis
12.3.1. By Country
12.3.2. By Product Type
12.3.3. By Application
12.4. Key Takeaways
13. Key Countries Market Analysis
13.1. USA
13.1.1. Pricing Analysis
13.1.2. Market Share Analysis, 2022
13.1.2.1. By Product Type
13.1.2.2. By Application
13.2. Canada
13.2.1. Pricing Analysis
13.2.2. Market Share Analysis, 2022
13.2.2.1. By Product Type
13.2.2.2. By Application
13.3. Brazil
13.3.1. Pricing Analysis
13.3.2. Market Share Analysis, 2022
13.3.2.1. By Product Type
13.3.2.2. By Application
13.4. Mexico
13.4.1. Pricing Analysis
13.4.2. Market Share Analysis, 2022
13.4.2.1. By Product Type
13.4.2.2. By Application
13.5. Germany
13.5.1. Pricing Analysis
13.5.2. Market Share Analysis, 2022
13.5.2.1. By Product Type
13.5.2.2. By Application
13.6. United Kingdom
13.6.1. Pricing Analysis
13.6.2. Market Share Analysis, 2022
13.6.2.1. By Product Type
13.6.2.2. By Application
13.7. France
13.7.1. Pricing Analysis
13.7.2. Market Share Analysis, 2022
13.7.2.1. By Product Type
13.7.2.2. By Application
13.8. Spain
13.8.1. Pricing Analysis
13.8.2. Market Share Analysis, 2022
13.8.2.1. By Product Type
13.8.2.2. By Application
13.9. Italy
13.9.1. Pricing Analysis
13.9.2. Market Share Analysis, 2022
13.9.2.1. By Product Type
13.9.2.2. By Application
13.10. China
13.10.1. Pricing Analysis
13.10.2. Market Share Analysis, 2022
13.10.2.1. By Product Type
13.10.2.2. By Application
13.11. Japan
13.11.1. Pricing Analysis
13.11.2. Market Share Analysis, 2022
13.11.2.1. By Product Type
13.11.2.2. By Application
13.12. South Korea
13.12.1. Pricing Analysis
13.12.2. Market Share Analysis, 2022
13.12.2.1. By Product Type
13.12.2.2. By Application
13.13. Singapore
13.13.1. Pricing Analysis
13.13.2. Market Share Analysis, 2022
13.13.2.1. By Product Type
13.13.2.2. By Application
13.14. Thailand
13.14.1. Pricing Analysis
13.14.2. Market Share Analysis, 2022
13.14.2.1. By Product Type
13.14.2.2. By Application
13.15. Indonesia
13.15.1. Pricing Analysis
13.15.2. Market Share Analysis, 2022
13.15.2.1. By Product Type
13.15.2.2. By Application
13.16. Australia
13.16.1. Pricing Analysis
13.16.2. Market Share Analysis, 2022
13.16.2.1. By Product Type
13.16.2.2. By Application
13.17. New Zealand
13.17.1. Pricing Analysis
13.17.2. Market Share Analysis, 2022
13.17.2.1. By Product Type
13.17.2.2. By Application
13.18. GCC Countries
13.18.1. Pricing Analysis
13.18.2. Market Share Analysis, 2022
13.18.2.1. By Product Type
13.18.2.2. By Application
13.19. South Africa
13.19.1. Pricing Analysis
13.19.2. Market Share Analysis, 2022
13.19.2.1. By Product Type
13.19.2.2. By Application
13.20. Israel
13.20.1. Pricing Analysis
13.20.2. Market Share Analysis, 2022
13.20.2.1. By Product Type
13.20.2.2. By Application
14. Market Structure Analysis
14.1. Competition Dashboard
14.2. Competition Benchmarking
14.3. Market Share Analysis of Top Players
14.3.1. By Regional
14.3.2. By Product Type
14.3.3. By Application
15. Competition Analysis
15.1. Competition Deep Dive
15.1.1. Sanofi SA
15.1.1.1. Overview
15.1.1.2. Product Portfolio
15.1.1.3. Profitability by Market Segments
15.1.1.4. Sales Footprint
15.1.1.5. Strategy Overview
15.1.1.5.1. Marketing Strategy
15.1.2. Amgen Inc.
15.1.2.1. Overview
15.1.2.2. Product Portfolio
15.1.2.3. Profitability by Market Segments
15.1.2.4. Sales Footprint
15.1.2.5. Strategy Overview
15.1.2.5.1. Marketing Strategy
15.1.3. Novartis International AG
15.1.3.1. Overview
15.1.3.2. Product Portfolio
15.1.3.3. Profitability by Market Segments
15.1.3.4. Sales Footprint
15.1.3.5. Strategy Overview
15.1.3.5.1. Marketing Strategy
15.1.4. AdooQ Bioscience
15.1.4.1. Overview
15.1.4.2. Product Portfolio
15.1.4.3. Profitability by Market Segments
15.1.4.4. Sales Footprint
15.1.4.5. Strategy Overview
15.1.4.5.1. Marketing Strategy
15.1.5. Thermo Fisher Scientific
15.1.5.1. Overview
15.1.5.2. Product Portfolio
15.1.5.3. Profitability by Market Segments
15.1.5.4. Sales Footprint
15.1.5.5. Strategy Overview
15.1.5.5.1. Marketing Strategy
15.1.6. Universal Biologicals
15.1.6.1. Overview
15.1.6.2. Product Portfolio
15.1.6.3. Profitability by Market Segments
15.1.6.4. Sales Footprint
15.1.6.5. Strategy Overview
15.1.6.5.1. Marketing Strategy
15.1.7. Selleck Chemicals
15.1.7.1. Overview
15.1.7.2. Product Portfolio
15.1.7.3. Profitability by Market Segments
15.1.7.4. Sales Footprint
15.1.7.5. Strategy Overview
15.1.7.5.1. Marketing Strategy
15.1.8. Madrigal Pharmaceuticals
15.1.8.1. Overview
15.1.8.2. Product Portfolio
15.1.8.3. Profitability by Market Segments
15.1.8.4. Sales Footprint
15.1.8.5. Strategy Overview
15.1.8.5.1. Marketing Strategy
15.1.9. ShangHai Caerulum Pharma Discovery Co., Ltd.
15.1.9.1. Overview
15.1.9.2. Product Portfolio
15.1.9.3. Profitability by Market Segments
15.1.9.4. Sales Footprint
15.1.9.5. Strategy Overview
15.1.9.5.1. Marketing Strategy
15.1.10. Wuhan Biocar Pharmacy
15.1.10.1. Overview
15.1.10.2. Product Portfolio
15.1.10.3. Profitability by Market Segments
15.1.10.4. Sales Footprint
15.1.10.5. Strategy Overview
15.1.10.5.1. Marketing Strategy
16. Assumptions & Acronyms Used
17. Research Methodology
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Heterozygous Familial Hypercholesterolemia (HEFH) Management Market
