Fucosidosis Therapeutics Market Outlook From 2025 to 2035

The fucosidosis therapeutics market shows smooth expansion through the 2025 to 2035 timeframe because researchers enhance their efforts and develop enzyme replacement therapies while the publicombatizes information regarding rare lysosomal storage disorders. Healthcare professionals need to develop new therapeutic methods to treat Fucosidosis because this rare inherited metabolic disease results from defective alpha-L-fucosidase enzyme functions.

The global fucosidosis therapeutics market is expected to garner a market value of USD 11.23 Million in 2025 and is expected to accumulate a market value of USD 19.55 Million till 2035 by registering a CAGR of 5.7% in the forecast period 2023 to 2033.

The market experiences expansion because investors make increasing funds available for gene therapy and enzyme replacement therapy (ERT) and small-molecule drugs. The market receives further expansion support through governmental backing of both rare disease investigation and orphan drug development programs. Pharmaceutical companies working together with research institutions speeds up the development process for specific treatments used in fucosidosis drug creation.

The market development faces hurdles because treatment expenses remain elevated while the number of patients eligible for treatment remains limited and clinical trial procedures prove complex. These market challenges push companies to enhance diagnostic programs and maximize treatment effectiveness and provide treatment access through patient support and regulatory benefits.

Key Market Metrics

Metric Value
Industry Size (2025E) USD 11.23 Million
Industry Value (2035F) USD 19.55 Million
CAGR (2025 to 2035) 5.7%

The fucosidosis therapeutics market segments its offerings based on treatment type and end-user application as hospitals along with research institutions and specialty clinics raise their market demand. Enzyme replacement therapy (ERT) joins gene therapy and supportive care medications form the main therapeutic categories. The main therapeutic intervention for Fucosidosis patients is ERT because it helps recover alpha-fucosidase activity which delays the progression of disease symptoms.

The development of targeted genetic modifications by researcher’s shows promising potential because it allows for enzyme deficiency correction at the cellular foundation. The essential aspects of patient quality of life improvement continue to rely on supportive care measures including physical therapy along with symptom control protocols.

The primary consumer base for healthcare services in fucosidosis management consists of specialty clinics and hospitals which deliver complex procedures alongside disease administration solutions. The development of fucosidosis therapeutics depends heavily on the research activities conducted by academic and medical research facilities across the healthcare sector.

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Regional Market Trends

North America

In North America, the fucosidosis therapeutics market is flourishing owing to backing for research into rare diseases and leading biotech companies. The FDA orphan drug incentives, the regulatory support and high clinical trial activity in the USA and Canada are all stakeholders in this growing market over the next seven years. Furthermore, increasing collaborations among research institutions and pharmaceutical companies facilitate the development of gene therapies and novel treatment options.

Europe

The Europe fucosidosis therapeutics market is well-established, with government support, a developed healthcare system, and participation in rare disease programs. Germany, France, and the UK are the key markets in Europe, driven by strong investment in lysosomal storage disorder research. As for the EMA, it has regulatory pathways for orphan drugs to be approved, leading to faster market access for newly developed therapeutic agents. Moreover, patient advocacy groups can also contribute to the raising of awareness and access to treatments.

Asia-Pacific

Fucosidosis therapeutics market in Asia-Pacific is expected to grow at the fastest rate due to the growing investments in healthcare, expanding capabilities in genetic research, and increasing awareness about diseases among patients. Nations like China, India, Japan, and South Korea experience increasingly interest in research and treatment progress in rare diseases.

The expansion of the market is also attributed to government initiatives to promote the development of orphan drugs as well as international collaborations in gene therapy research. Although there continue to be challenges surrounding access to diagnostics and treatment, ongoing investments in biotechnology and healthcare infrastructure bode well for long-term growth in the region.

Challenges and Opportunities

Challenge: Limited Treatment Options and High Research Costs

The fucosidosis therapeutics market struggles because the disease affects few patients while there are no approved medical treatments available. Fucosidosis exists as a lysosomal storage disorder because of alpha-L-fucosidase deficiency while its treatment lacks both disease-modifying methods and effective therapeutic choices.

Excessive expenses related to research development and clinical trials and regulatory approvals pose extra barriers for drug developers within this small market space which makes substantial investment difficult to justify. Disease awareness deficiencies and incorrect diagnosis delays both prevent medical professionals from applying early interventions and obtaining successful patient management outcomes.

Opportunity: Advances in Gene Therapy and Enzyme Replacement Therapies

Increasing interest in orphan drugs, gene therapy medicines, and ERTs provides with a strong opportunity for fucosidosis therapeutics market. Emerging gene-editing approaches such as CRISPR-based strategies may develop curative therapies to correct the underlying genetic mutation.

Research on enzyme replacement therapy and small-molecule therapies is promising as a way to slow fucosidosis progression simultaneously. Regulatory advantages like orphan drug designations, priority review processes, and research funding grants for rare diseases incentivize pharma companies to pursue fucosidosis treatment projects, potentially broadening the available therapeutic arsenal for affected individuals.

Shifts in the Fucosidosis Therapeutics Market from 2020 to 2024 and Future Trends 2025 to 2035

From 2020 to 2024, there was a rise in research activities related to fucosidosis therapeutics, particularly in gene therapy and enzyme replacement therapy. Interest in developing novel therapies was aided by an expansion of funding for orphan drugs, as well as the establishment of clinical trial networks for rare diseases.

But small patient populations, slow clinical trial recruitment and high treatment costs continued to pose significant hurdles. Support groups and advocacy organizations set out to raise disease awareness and introduce genetic screening programs, leading to earlier diagnosis and getting patients enrolled in clinical studies.

The market will further shift towards more targeted gene therapy, better enzyme formulations, and precision medicine approaches from 2025 to 2035. Clinical and preclinical drug trials will spur further discoveries, as will improved protocols for widespread screening of new-borns in addition to concerted efforts worldwide to promote early detection.

Furthermore, drug repurposing and biomarker studies will enhance treatment pathways and come up with better therapeutic options. Broader market accessibility will be supported by an increasing focus on patient-centric healthcare models, improved insurance coverage for rare disease treatments and global rare disease policy frameworks.

Market Shifts: A Comparative Analysis (2020 to 2024 vs. 2025 to 2035)

Market Shift 2020 to 2024
Regulatory Landscape Orphan drug designations and funding supported research efforts.
Technological Advancements Early-stage research in gene therapy and enzyme replacement strategies.
Treatment Availability Limited to symptom management and supportive care.
Diagnosis and Screening Awareness campaigns and genetic screening programs expanded.
Research and Development Clinical trials faced challenges in patient recruitment and funding.
Patient Advocacy and Support Increased involvement of rare disease organizations in awareness efforts.
Market Growth Drivers Due to orphan drug incentives, rising research effort and advocacy group campaigns
Market Shift 2025 to 2035
Regulatory Landscape Global policy frameworks and expanded insurance coverage will improve access to new treatments.
Technological Advancements Refined gene-editing technologies and improved enzyme formulations will drive therapeutic breakthroughs.
Treatment Availability Introduction of disease-modifying therapies, gene therapy approvals, and targeted treatment options.
Diagnosis and Screening New-born screening integration and AI-driven diagnostic tools will enhance early detection.
Research and Development Global research collaborations and accelerated trial designs will streamline drug development.
Patient Advocacy and Support Improved genetic counselling and enhanced patient engagement coupled with greater access to clinical trials will help support market growth.
Market Growth Drivers Expansion fuelled by next-generation therapeutics, precision medicine, and improved global healthcare access.

Country-Wise Outlook

United States

The United States fucosidosis therapeutics market is broadly impacted by several factors, including detailed understanding of fucosidosis mechanisms, breakthrough in lysosomal storage disorders treatment, rapid advancement of gene therapy, and recent novel introduction of recombinant fucosidase. The pioneering biopharmaceutical companies and academic research institutes have enabled the rapid development of enzyme replacement therapies (ERTs) and gene therapy-based drugs for fucosidosis.

Primes that identifications of reforms improve news publications pharmaceutical (SRT) and Chaperone therapies applications, Government support, including incentives (Via the Orphan Drug Act) and cash (Via the National Institutes of Health (NIH)), is promoting research into novel treatment approaches like substrate reduction therapy (SRT) and chaperone Therapy applications.

The increasing number of clinical trials and rising investments in next-generation genetic therapeutics should continue to spur market growth. And early diagnosis and access to cutting-edge therapeutics is being increasingly supported by patient advocacy groups and rare disease foundations.

Country CAGR (2025 to 2035)
USA 5.9%

United Kingdom

The UK Fucosidosis Therapeutics market is driven by growing government support for rare disease research due to the increasing burden of diseases, growing advanced genetic screening availability, increasing support and collaborations between pharma companies and academic institutes. Orphan drug development and access to orphan drugs is actively supported in England by the National Health Service (NHS) and National Institute for Health Research (NIHR).

Participation in global clinical trials of enzyme replacement therapies and gene-editing technologies is further driving fucosidosis treatment innovation in the UK. Moreover, patient-centred initiatives as well as regulatory encouragement from the Medicines and Healthcare Products Regulatory Agency (MHRA) is facilitating the faster approval and commercialization of new therapeutics. The rising adoption of next-generation sequencing (NGS) coupled with increasing new-born screening initiatives is anticipated to enhance early diagnosis and therapeutics intervention rates resulting in market growth.

Country CAGR (2025 to 2035)
UK 5.6%

European Union

Favourable orphan drug laws, high-level research funding, and increasing partnerships between pharmaceutical companies and rare diseases organizations are driving the growth of the European Union fucosidosis therapeutics market. The market is dominated by countries including Germany, France, and Italy due to their high investments in gene therapy, personalized medicine, and enzyme-based drug development.

The European Medicines Agency Orphan Drug Designation Program is helping to accelerate the development of new fucosidosis drugs by providing regulatory and financial incentives. Experiments with stem cell therapy and gene-editing tools like CRISPR-Cas9 are also being explored to address the issue of limited availability of marrow sources in the coming years. Patient registries for rare diseases and new-born screening programs are growing in Europe too, in turn raising rates of early diagnosis, which can make treatment available sooner and spur research.

Region CAGR (2025 to 2035)
European Union 5.8%

Japan

Japan’s fucosidosis therapeutics market has been witnessing number of factors such as government-supported rare diseases initiative programs, rise in genetic research advancements and dominance of biopharmaceuticals innovations. The Ministry of Health, Labour and Welfare (MHLW) in Japan has implemented orphan drug incentives, which will encourage companies to invest in novel enzyme replacement therapies and gene-based therapies in Japan.

AI-driven drug discovery and regenerative medicine technologies are combining in such a way that Japan is no longer playing the game of catch-up but is bigger than ever in getting to the next level in precision therapies for lysosomal storage disorders such as fucosidosis. Moreover, increasing awareness of rare genetic disorders and increased implementation of new-born genetic screening programs are projected to propel early detection and timely treatment of myopathy. Another driver for the market growth is the focus of Japan's pharmaceutical industry on cell and gene therapy.

Country CAGR (2025 to 2035)
Japan 5.7%

South Korea

South Korea Fucosidosis therapeutics market outlook, the South Korean fucosidosis therapeutics market is driven by rising investment in rare disease research, emerging biotechnology, & increasing patient access to novel therapeutics. Government initiatives (e.g., orphan drug policy) as well as increased funding specifically for rare diseases are promoting competition in clinical trials and drug development efforts.

Singapore’s robust biotechnology sector and collaborations with international pharmaceutical companies are contributing to progress in enzyme replacement therapy, gene therapy and small-molecule drug development for fucosidosis. Moreover, the prosperous healthcare infrastructure in South Korea and the rising awareness about genetic disorders are facilitating the growth of the market in the country. The increasing acceptance and implementation of precision medicine programs is also anticipated to improve personalized treatment strategies for lysosomal storage disorders.

Country CAGR (2025 to 2035)
South Korea 5.7%

Segmentation Outlook - Fucosidosis Therapeutics Market

Bone Marrow Transplantation and Hospital Segments Drive Market Growth as Demand for Effective Treatment and Specialized Care Increases

Due to an increasing requirement and demand for successful and permanent therapeutic approaches, the fucosidosis therapeutics market is led by the bone marrow transplantation and hospital segment. Although bone marrow transplantation is a critical treatment option in patients with fucosidosis, it can only help to retard disease progression and restore the neurological functions.

Also, hospitals remain the first healthcare place where a specialist and more technical therapeutic procedures and all degree monitoring of fucosidosis patients are performed. These segments are still pushing the market growth as medical developments and knowledge about rare genetic disorders continue to grow.

Bone marrow transplantation remains the most promising therapeutic option for fucosidosis, as it allows the repopulation of defective hematopoietic stem cells with normal donor cells, thus preventing possible further neurodegeneration. On one hand, hospitals offer a controlled environment with specialized teams that aid a complete disease management spanning pre-transplant preparation to post-transplant follow-up and supportive care. The corporation is successfully expanding its market will due to the continued research and advancements in transplantation techniques.

With the promise of modifying disease course, bone marrow transplantation (BMT) has emerged over the last decade as the preferred and only effective therapy for fucosidosis through the delivery and production of functional enzymes in the patient. As fucosidosis is due to the deficiency of the enzyme alpha-L-fucosidase, BMT could theoretically restore enzyme activity, reducing the accumulation of toxic metabolites in the cells and tissues [95].

BMT are reiterated for paediatric patients with early-stage fucosidosis as early intervention will more likely abolish neurological degeneration. The process requires the defective bone marrow stem cells to be replaced with healthy donor cells, hoping those cells will lead to functional enzymes to ameliorate the symptoms of the disease. Independent studies have available for the improvement of brain functioning, bettering the organ dysfunction and enhancing the survival ratio of the patients.

Although BMT has proven to have therapeutic benefits, it also has complications, most notably the risk for graft-versus-host disease (GVHD), infection, or immune toxicity. In order to counter these risks, researchers are continuously refining transplantation techniques, employing new methods such as gene editing, immune-modulating therapies and reduced-intensity conditioning regimens. With the increased number of donor matching programs, and continued improvements in transplantation procedures, the prevalence and success of BMT as a fucosidosis treatment have been increasing, solidifying BMT's role in the therapeutics market.

Bone marrow transplantation evolution

Fortunately, noteworthy advancements in the techniques for bone marrow transplantation have led to improved outcomes for this complex process, thus giving rise to consideration of bone marrow transplantation in the treatment of fucosidosis [1]. Innovations in donor selection, such as haploidentical transplantation and umbilical cord blood stem cell transplantation, have increased the availability of appropriate donors for patients with rare genetic disorders. These developments optimize BMT and minimize deficiencies in treatment and efficacy.

Moreover, precision medicine also has led to advancements in transplantation practices through genetic screening and the use of molecular diagnostics for the assessment of donor and recipient compatibility. Stem cell engineering combined with gene therapy offers exciting new strategies for BMT, advancing the treatment towards a one-size-fits-all solution for each patient's profile. With ongoing studies, the combination of BMT with enzyme replacement therapy and gene therapy will only be expected to emerge more effective and preferably less invasive.

Advancements in post-transplant immunosuppression strategies, which have reduced transplant-related rejection and other complications, have also improved outcomes after HLA-mismatched transplants. New pharmacological support techniques, such as selective immunosuppressive agent medication, have decreased the frequency of GVHD and maintained the function of the graft. These advancements showcase the evolving nature of bone marrow transplantation and reaffirm its place as a key therapeutic modality in the treatment of fucosidosis.

Hospitals Lead the Market as Primary Centers for Fucosidosis Diagnosis and Treatment

Hospital will continue being the key end-users segment in the fucosidosis therapeutics market, as hospital entities is the major contributor for diagnosis, treatment, and long-term disease management. In a hospital environment, specialty healthcare teams that include geneticists, neurologists, immunologists and transplant specialists work together to manage a disorder that can take many forms. Moreover, the increase in advanced diagnostic tools and the establishment of intensive care units (ICUs) supporting patient care also play a prominent role in accentuating the hospital segment for disease management.

Bone marrow transplantation is conducted at the hospital and providing the infrastructure for a successful transplant, post-operative monitoring, supportive care, and management of transplant-related complications is an essential component of that care [1]. These centres manage use of critical therapies like enzyme replacement therapy, physiotherapy and nutritional therapy. Hospitals continue to spearhead research and clinical trials for new fucosidosis therapies, as health technology assessment (HTA) providers run cost-effectiveness analysis studies based on data available until October 2023, focusing on early intervention strategies.

Finally, hospitals play a critical role beyond treatment, serving as important centres for education and counselling of patients and families about the disease, possible treatments, and genetic counselling. Such multidisciplinary hospital-based programs provide patients with tailored treatment strategies for the disease, taking into consideration the medical and psychosocial nature of the disease. Hospitals still serve as the heart of the treatment and management of fucosidosis disease, with ongoing elites of infrastructure and its worldwide investment in healthcare and research.

Specialized units for Frosted Fucosidosis patients expand

As we gain awareness of rare genetic disorders, attention to lysosomal storage diseases is growing, and some hospitals have created specialized units for such diseases, including fucosidosis. These centres are often involved in the early diagnosis, multidisciplinary treatment planning, and long-term follow-up of patients to provide the best management throughout the course of their disease. Through partnership with research institutions and pharmaceutical companies, hospitals participate in the research of transformative therapies; a collaboration that helps to bring new therapeutics to patients faster.

Remote patient monitoring and telemedicine have broadened the hospital-based care concept and delivered permanent medical support for fucosidosis patients. Real-time tracking of disease progression through the use of digital health platforms also allows a healthcare provider to fine-tune a treatment regimen to a given patient. These technologies create a seamless transition between in-hospital and home-based treatment, allowing patients to maintain constant communication with medical professionals regardless of distance.

Hospitals also serve as an important site of clinical trials, where patients can enrol in experimental therapies with investigational drugs. Incubated research-focused hospital programs are investigating various gene-editing techniques, enzyme replacement approaches, and small-molecule drugs to modify the underlying fucosidosis pathology. As these novel therapeutic modalities progress toward clinical use, hospitals will continue to play a central role in their delivery and evaluation, further cementing their position in the therapeutic landscape.

Competitive Outlook

The therapeutics for fucosidosis has a niche yet competitive market, as dugs in pipeline process for fucosidosis and there is the continuous development of new drugs to combat this rare disease. Overview of fucosidosis results from the deficiency of the enzyme alpha-L-fucosidase and causes progressive neurologic and systemic disease.

At present, there are limited treatment options with active investigations toward enzyme replacement therapy (ERT), gene therapy and supportive care modalities. The market is driven mainly by biopharmaceutical companies, rare disease specialists, and academic research institutes focusing on novel therapy solutions.

Market Share Analysis by Company

Company Name Estimated Market Share (%)
JCR Pharmaceuticals Co., Ltd. 20-25%
Takeda Pharmaceutical Company Limited 15-19%
Denali Therapeutics Inc. 12-16%
Orphazyme A/S 8-12%
Greenovation Biotech GmbH 5-9%
Other Companies (combined) 30-40%

Key Company Offerings and Activities

Company Name Key Offerings/Activities
JCR Pharmaceuticals Co., Ltd. Developing enzyme replacement therapy (ERT) for lysosomal storage disorders, including potential therapies for fucosidosis.
Takeda Pharmaceutical Company Limited Researching novel treatment approaches for rare metabolic diseases, with a focus on gene therapy solutions.
Denali Therapeutics Inc. Working on brain-penetrant enzyme therapeutics for neurodegenerative lysosomal disorders, including fucosidosis.
Orphazyme A/S Specializes in heat shock protein-based therapies for lysosomal storage diseases, targeting neurodegenerative aspects of fucosidosis.
Greenovation Biotech GmbH Focuses on plant-based recombinant enzyme production for orphan disease treatments, including fucosidosis.

Key Company Insights

JCR Pharmaceuticals Co., Ltd. (20-25%)

JCR is a leader in ERT research for lysosomal storage disorders such as fucosidosis.

Takeda Pharmaceutical Company Limited (15-19%)

Investing in gene therapy and novel treatment pathways to deliver potentially curative therapies for fucosidosis and other rare metabolic diseases.

Denali Therapeutics Inc. (12-16%)

Denali is developing blood-brain barrier-penetrant enzyme therapies, in an attempt to treat the neurological symptoms of fucosidosis.

Orphazyme A/S (8-12%)

Note that Orphazyme is working on heat shock protein-based drug candidates that have the potential to enhance protein stability in patients with fucosidosis.

Greenovation Biotech GmbH (5-9%)

Plant-based recombinant enzyme production In order to make this biopharmaceutical antibody, Greenovation is pioneering plant-based production system and providing potentially much cheaper solution for lysosomal storage disorders.

Other Generalists (30-40%), Composite Players

Many other pharmaceutical companies, biotech companies and research institutes also participate to some extent in the fucosidosis therapeutics market, either through preclinical or clinical research, drug repurposing, or new enzyme therapies:

  • ULTRAGENE PHARMA INC.
  • Bio Marin Pharmaceutical Inc.
  • Sangamo Therapeutics, Inc.
  • REGENXBIO Inc.
  • Avrobio, Inc.
  • Abeona Therapeutics Inc.
  • Lysogene S.A.

Frequently Asked Questions

What was the overall size of the fucosidosis therapeutics market in 2025?

The overall market size for the fucosidosis therapeutics market was USD 11.23 million in 2025.

How big is the fucosidosis therapeutics market expected to be in 2035?

The fucosidosis therapeutics market is expected to reach USD 19.55 million in 2035.

What will drive the demand for the fucosidosis therapeutics market during the forecast period?

The increasing prevalence of rare lysosomal storage disorders, rising advancements in enzyme replacement therapies, and growing focus on early diagnosis and treatment fuel the fucosidosis therapeutics market during the forecast period.

List the top 5 countries contributing to the fucosidosis therapeutics market.

The top 5 countries driving the development of the fucosidosis therapeutics market are the USA, UK, European Union, Japan, and South Korea.

Which segment in type is expected to lead in the fucosidosis therapeutics market?

Antibiotic therapy leads market growth to command a significant share over the assessment period.

Table of Content
  1. Executive Summary
  2. Industry Introduction, including Taxonomy and Market Definition
  3. Market Trends and Success Factors, including Macro-economic Factors, Market Dynamics, and Recent Industry Developments
  4. Global Market Demand Analysis 2020 to 2024 and Forecast 2025 to 2035, including Historical Analysis and Future Projections
  5. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035
    • Therapy
    • End User
  6. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Therapy
    • Antibiotic Therapy
    • Fluid Replacement Therapy
    • Bone Marrow Transplantation
  7. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By End User
    • Hospital
    • Homecare
    • Specialty Clinics
    • Others
  8. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Region
    • North America
    • Latin America
    • Western Europe
    • Eastern Europe
    • East Asia
    • South Asia Pacific
    • Middle East and Africa
  9. North America Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  10. Latin America Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  11. Western Europe Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  12. Eastern Europe Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  13. East Asia Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  14. South Asia Pacific Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  15. Middle East and Africa Sales Analysis 2020 to 2024 and Forecast 2025 to 2035, by Key Segments and Countries
  16. Sales Forecast 2025 to 2035 by Therapy for 30 Countries
  17. Competition Outlook, including Market Structure Analysis, Company Share Analysis by Key Players, and Competition Dashboard
  18. Company Profile
    • Sigma-Aldrich
    • BD (Becton, Dickinson and Company)
    • Enzo Life Sciences
    • Creative Diagnostics
    • Thermo Fisher Scientific
    • Epitope Diagnostics Inc.
    • Research and Development Systems
    • QED Bioscience Inc.
    • ACROBiosystems

Fucosidosis Therapeutics Market Segmentation

By Therapy:

  • Antibiotic Therapy
  • Fluid Replacement Therapy
  • Bone Marrow Transplantation

By End-User:

  • Hospital
  • Homecare
  • Specialty Clinics
  • Others

By Region:

  • North America
  • Latin America
  • Western Europe
  • Eastern Europe
  • East Asia
  • South Asia Pacific
  • Middle East and Africa

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