The global diamond-blackfan anemia (DBAAASE) syndrome therapeutics market size is expected to surpass an impressive valuation of US$ 4.8 billion in 2023 and is projected to exhibit a CAGR of 4.2% from 2023 to 2033. A valuation of US$ 7.29 billion is expected for the market by the end of the aforementioned period of assessment
Diamond-blackfan anemia is an inherited blood disorder that impairs bone marrow's capacity to generate red blood cells. It is a form of bone marrow malfunction. It is also referred to as obtained pure red cell aplasia and is induced by genetic mutations. Light skin, loss of energy, fast heartbeat, unusual thumbs, low bone density, cleft palate, and heart and kidney difficulties are all symptoms of this disorder. Erythrogenesis imperfecta, DBA, congenital hypoplastic anemia, inherited erythroblastopenia, and congenital pure red cell aplasia is all identities for this condition.
Although most cases are isolated, approximately 45% of people with Diamond-Blackfan anemia inherit the disorder from one of their parents. The increased incidences of diamond-blackfan anemia, burgeoning healthcare expenditure, advancement of therapeutic approaches, soaring federal funding, and surging strategies by government and private organizations to raise illnesses awareness are the aspects that will drive the diamond-blackfan anemia treatment market.
| Report Attribute | Details |
|---|---|
| Expected Market Value (2023) | US$ 4.8 billion |
| Anticipated Forecast Value (2033) | US$ 7.29 billion |
| Projected Growth Rate (2023 to 2033) | 4.2% CAGR |
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Since hematologic complications develop in 90% of infected persons during their first year of life, a rise in the number of blood disorders propelled the global diamond-blackfan anemia treatment market over the historical period. Aplastic anemia is being raised awareness by organizations such as the National Organization for Rare Disorders, Inc. and CancerIndex, among others. The Aplastic Anemia Trust's spring awareness campaign was launched in February 2019.
The pandemic has diminished the number of charitable blood donations and interrupted the global supply chain for medical equipment. Reduced donor inflow, a lack of staff members, a scarcity of blood units, and general concern about transfusion-transmitted COVID-19 were among the major obstacles confronted by blood banks and clinics from 2020 to 2021. From 2018 to 2022, the market witnessed significant growth, registering a CAGR of 3.8%.
Furthermore, rising government support for R&D, changing lifestyles, and rapidly evolving technology are expected to drive market expansion over the forecast period.
Supportive Laws by Government Entities to Spur Market Expansion
The existence of supportive regulations by governmental agencies, such as the Orphan Drug Act, which encourages product development by awarding orphan drug certification to potential drug delivery developed by drug manufacturers, is anticipated to boost industry growth. This initiative promotes study and advancement in the treatment of diamond-blackfan anemia.
According to a recent article, the US Food and Drug Administration has approved approximately 21 to 22 novel drugs and biopharmaceuticals for more than 800 rare disease indications. Furthermore, burgeoning genomics investigations have resulted in the discovery of effective biologic drugs for rare genetic disorders. These aspects have significantly boosted the market for diamond-blackfan anemia treatment.
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Increasing government expenditure on research, development, and therapeutic interventions is expected to propel the market's growth in the coming decade. For instance, in India, the National Policy for Rare Diseases, 2021 (the Policy) has been accomplished and publicly disclosed.
According to the provisions envisioned in the National Policy for Rare Diseases, 2021, concerning providing economic assistance to individuals with rare diseases, it is proposed that funding will be offered under the umbrella scheme of RAN, i.e. an amount up to Rs. 20 lakhs (US$ 24,358) only for privileged claimants will be offered by the Central Government. As a result, the market for diamond-blackfan anemias treatment is expected to grow.
High Costs and Complicated Side Effects to Hinder Market Growth
The elevated cost of treatment and complications linked to the disease, such as leukemia, osteosarcoma, acute myeloid leukemia, and myelodysplastic syndrome, will impede overall growth and pose significant challenges to the diamond-blackfan anemia treatment market in the coming years. A stem cell transplant costs more than US$ 290,000. As a consequence, the elevated cost of treatment is inclined to stifle growth in the market.
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Major notable stakeholders, high disposable income to drive the North American market
Owing to the existence of major prominent stakeholders, high expendable income, elevated health expenditures, and a well-established medical industry in this region, North America dominates the diamond-blackfan anemia treatment market. According to a report released by Clevel and Clinic, the DBA Registry of North America, a database with data on individuals who have this disorder, 25% of people with DBA die by the age of 50 from associated medical disorders.
North America will dominate the market in 2021 with a sales revenue of more than 60.0% owing to the high incidence of diseases, sophisticated healthcare infrastructure, and unique product authorizations for diagnosis. Tezepelumab received orphan drug certification from the US FDA in October 2021. Exposure to orphan drugs for diamond-blackfan anemia treatment may enhance patient adherence, thereby broadening the consumer base and elevating industry revenue. North America is expected to hold approximately 40% market share.
Innovative drugs development to drive the European market
Autologous CD34+ enriched cells transduced with a self-inactivating lentiviral vector containing the codon-optimized RPS19 gene drug were identified as an orphan medication for the treatment of Diamond-Blackfan anemia in the European Union on November 12, 2021. This means that the developer will receive scientific and regulatory assistance from the EMA to advance their medicine to the point where they can apply for marketing authorization, which will boost the market growth in this region.
DBA UK is a registered charity (1083179) ruled by a written constitution and operated by elected volunteer groups. They provide support, studies, and hope to the DBA community by introducing families together to converse about their experiences, convey the most up-to-date medical records, and raise funds to help those with DBA in the United Kingdom. As a result, this venture is predicted to benefit the European market. The Europe market is expected to expand with a CAGR of 3.7%.
Corticosteroids are among the most widely prescribed Medicine Classes Worldwide
Customers are drawn to corticosteroids because they are available in a variety of forms, including oral capsules or tablets, oral syrups, injectables, topical creams or gels, and nasal sprays.
Corticosteroids are also one of the most frequently prescribed drug classes globally, with a market worth more than US$ 10 billion per year, according to a National Library of Medicine report. As a result of the aforementioned factors, the corticosteroids segment is expected to grow significantly during the forecast period.
The blood Transfusions Segment is predicted to Expand Quickly
The adoption of advanced molecular systems by market leaders accelerates the transition from test cases and instruments to automated devices. These automated systems have been critical in detecting Transfusion Transmissible Infections (TTIs) in samples taken and can accurately avoid human error during the transfusion method. As a result, the blood transfusions segment is expected to expand rapidly, with a CAGR of 6.9%.
Prominent start-up players in the anorectal malformation treatment sector are introducing novel and innovative product lines to strengthen their market presence, and the aforementioned start-ups have left no stone unturned. The following are some specific examples of significant t start-ups:
Key players in the Diamond-Blackfan Anemia (DBAAASE) Syndrome Therapeutics market are Sumitomo Corporation, Johnson & Johnson Private Limited, Novartis AG, Pfizer Inc., Sanofi, Merck KGaA, LEO Pharma A/S, Cipla Inc., GlaxoSmithKline plc, AstraZeneca, Abbott Laboratories and Bayer AG.
| Report Attribute | Details |
|---|---|
| Expected Market Value (2023) | USS 4.8 billion |
| Anticipated Forecast Value (2033) | US$ 7.29 billion |
| Projected Growth Rate (2023 to 2033) | 4.1% CAGR |
| Base Year for Estimation | 2022 |
| Historical Data | 2018 to 2022 |
| Forecast Period | 2023 to 2033 |
| Quantitative Units | Revenue in US$ Billion and CAGR from 2023 to 2033 |
| Report Coverage | Revenue Forecast, Volume Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends, and Pricing Analysis |
| Segments Covered |
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| Regions Covered |
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| Key Countries Profiled |
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| Key Companies Profiled |
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| Customization | Available Upon Request |
The global market exhibited a 3.8% CAGR from 2018 to 2022.
The market is forecast to register a CAGR of 4.2% through 2033.
Corticosteroids are among the most widely prescribed medicine classes worldwide.
The blood transfusions segment is predicted to expand significantly.
High costs and complicated side effects are likely to hinder market growth.
1. Executive Summary | Diamond-Blackfan Anemia (DBAAASE) Syndrome Therapeutics Market
1.1. Global Market Outlook
1.2. Demand to side Trends
1.3. Supply to side Trends
1.4. Technology Roadmap Analysis
1.5. Analysis and Recommendations
2. Market Overview
2.1. Market Coverage / Taxonomy
2.2. Market Definition / Scope / Limitations
3. Market Background
3.1. Market Dynamics
3.1.1. Drivers
3.1.2. Restraints
3.1.3. Opportunity
3.1.4. Trends
3.2. Scenario Forecast
3.2.1. Demand in Optimistic Scenario
3.2.2. Demand in Likely Scenario
3.2.3. Demand in Conservative Scenario
3.3. Opportunity Map Analysis
3.4. Investment Feasibility Matrix
3.5. PESTLE and Porter’s Analysis
3.6. Regulatory Landscape
3.6.1. By Key Regions
3.6.2. By Key Countries
3.7. Regional Parent Market Outlook
4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033
4.1. Historical Market Size Value (US$ Million) Analysis, 2018 to 2022
4.2. Current and Future Market Size Value (US$ Million) Projections, 2023 to 2033
4.2.1. Y-o-Y Growth Trend Analysis
4.2.2. Absolute $ Opportunity Analysis
5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Treatment
5.1. Introduction / Key Findings
5.2. Historical Market Size Value (US$ Million) Analysis By Treatment, 2018 to 2022
5.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Treatment, 2023 to 2033
5.3.1. Corticosteroids
5.3.2. Chelation Therapy
5.3.3. Blood Transfusions
5.3.4. Stem Cell Transplant
5.3.5. Others
5.4. Y-o-Y Growth Trend Analysis By Treatment, 2018 to 2022
5.5. Absolute $ Opportunity Analysis By Treatment, 2023 to 2033
6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By End User
6.1. Introduction / Key Findings
6.2. Historical Market Size Value (US$ Million) Analysis By End User, 2018 to 2022
6.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By End User, 20232033
6.3.1. Hospitals
6.3.2. Clinics
6.3.3. Others
6.4. Y-o-Y Growth Trend Analysis By End User, 2018 to 2022
6.5. Absolute $ Opportunity Analysis By End User, 2023 to 2033
7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region
7.1. Introduction
7.2. Historical Market Size Value (US$ Million) Analysis By Region, 2018 to 2022
7.3. Current Market Size Value (US$ Million) Analysis and Forecast By Region, 2023 to 2033
7.3.1. North America
7.3.2. Latin America
7.3.3. Europe
7.3.4. Asia Pacific
7.3.5. Middle East & Africa (MEA)
7.4. Market Attractiveness Analysis By Region
8. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
8.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
8.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
8.2.1. By Country
8.2.1.1. US
8.2.1.2. Canada
8.2.2. By Treatment
8.2.3. By End User
8.3. Market Attractiveness Analysis
8.3.1. By Country
8.3.2. By Treatment
8.3.3. By End User
8.4. Key Takeaways
9. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
9.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
9.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
9.2.1. By Country
9.2.1.1. Brazil
9.2.1.2. Mexico
9.2.1.3. Rest of Latin America
9.2.2. By Treatment
9.2.3. By End User
9.3. Market Attractiveness Analysis
9.3.1. By Country
9.3.2. By Treatment
9.3.3. By End User
9.4. Key Takeaways
10. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
10.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
10.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
10.2.1. By Country
10.2.1.1. Germany
10.2.1.2. UK
10.2.1.3. France
10.2.1.4. Spain
10.2.1.5. Italy
10.2.1.6. Rest of Europe
10.2.2. By Treatment
10.2.3. By End User
10.3. Market Attractiveness Analysis
10.3.1. By Country
10.3.2. By Treatment
10.3.3. By End User
10.4. Key Takeaways
11. Asia Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
11.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
11.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
11.2.1. By Country
11.2.1.1. China
11.2.1.2. Japan
11.2.1.3. South Korea
11.2.1.4. Singapore
11.2.1.5. Thailand
11.2.1.6. Indonesia
11.2.1.7. Australia
11.2.1.8. New Zealand
11.2.1.9. Rest of Asia Pacific
11.2.2. By Treatment
11.2.3. By End User
11.3. Market Attractiveness Analysis
11.3.1. By Country
11.3.2. By Treatment
11.3.3. By End User
11.4. Key Takeaways
12. MEA Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
12.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022
12.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033
12.2.1. By Country
12.2.1.1. GCC Countries
12.2.1.2. South Africa
12.2.1.3. Israel
12.2.1.4. Rest of MEA
12.2.2. By Treatment
12.2.3. By End User
12.3. Market Attractiveness Analysis
12.3.1. By Country
12.3.2. By Treatment
12.3.3. By End User
12.4. Key Takeaways
13. Key Countries Market Analysis
13.1. USA
13.1.1. Pricing Analysis
13.1.2. Market Share Analysis, 2022
13.1.2.1. By Treatment
13.1.2.2. By End User
13.2. Canada
13.2.1. Pricing Analysis
13.2.2. Market Share Analysis, 2022
13.2.2.1. By Treatment
13.2.2.2. By End User
13.3. Brazil
13.3.1. Pricing Analysis
13.3.2. Market Share Analysis, 2022
13.3.2.1. By Treatment
13.3.2.2. By End User
13.4. Mexico
13.4.1. Pricing Analysis
13.4.2. Market Share Analysis, 2022
13.4.2.1. By Treatment
13.4.2.2. By End User
13.5. Germany
13.5.1. Pricing Analysis
13.5.2. Market Share Analysis, 2022
13.5.2.1. By Treatment
13.5.2.2. By End User
13.6. UK
13.6.1. Pricing Analysis
13.6.2. Market Share Analysis, 2022
13.6.2.1. By Treatment
13.6.2.2. By End User
13.7. France
13.7.1. Pricing Analysis
13.7.2. Market Share Analysis, 2022
13.7.2.1. By Treatment
13.7.2.2. By End User
13.8. Spain
13.8.1. Pricing Analysis
13.8.2. Market Share Analysis, 2022
13.8.2.1. By Treatment
13.8.2.2. By End User
13.9. Italy
13.9.1. Pricing Analysis
13.9.2. Market Share Analysis, 2022
13.9.2.1. By Treatment
13.9.2.2. By End User
13.10. China
13.10.1. Pricing Analysis
13.10.2. Market Share Analysis, 2022
13.10.2.1. By Treatment
13.10.2.2. By End User
13.11. Japan
13.11.1. Pricing Analysis
13.11.2. Market Share Analysis, 2022
13.11.2.1. By Treatment
13.11.2.2. By End User
13.12. South Korea
13.12.1. Pricing Analysis
13.12.2. Market Share Analysis, 2022
13.12.2.1. By Treatment
13.12.2.2. By End User
13.13. Singapore
13.13.1. Pricing Analysis
13.13.2. Market Share Analysis, 2022
13.13.2.1. By Treatment
13.13.2.2. By End User
13.14. Thailand
13.14.1. Pricing Analysis
13.14.2. Market Share Analysis, 2022
13.14.2.1. By Treatment
13.14.2.2. By End User
13.15. Indonesia
13.15.1. Pricing Analysis
13.15.2. Market Share Analysis, 2022
13.15.2.1. By Treatment
13.15.2.2. By End User
13.16. Australia
13.16.1. Pricing Analysis
13.16.2. Market Share Analysis, 2022
13.16.2.1. By Treatment
13.16.2.2. By End User
13.17. New Zealand
13.17.1. Pricing Analysis
13.17.2. Market Share Analysis, 2022
13.17.2.1. By Treatment
13.17.2.2. By End User
13.18. GCC Countries
13.18.1. Pricing Analysis
13.18.2. Market Share Analysis, 2022
13.18.2.1. By Treatment
13.18.2.2. By End User
13.19. South Africa
13.19.1. Pricing Analysis
13.19.2. Market Share Analysis, 2022
13.19.2.1. By Treatment
13.19.2.2. By End User
13.20. Israel
13.20.1. Pricing Analysis
13.20.2. Market Share Analysis, 2022
13.20.2.1. By Treatment
13.20.2.2. By End User
14. Market Structure Analysis
14.1. Competition Dashboard
14.2. Competition Benchmarking
14.3. Market Share Analysis of Top Players
14.3.1. By Regional
14.3.2. By Treatment
14.3.3. By End User
15. Competition Analysis
15.1. Competition Deep Dive
15.1.1. Sumitomo Corporation
15.1.1.1. Overview
15.1.1.2. Product Portfolio
15.1.1.3. Profitability by Market Segments
15.1.1.4. Sales Footprint
15.1.1.5. Strategy Overview
15.1.1.5.1. Marketing Strategy
15.1.2. Johnson & Johnson Private Limited
15.1.2.1. Overview
15.1.2.2. Product Portfolio
15.1.2.3. Profitability by Market Segments
15.1.2.4. Sales Footprint
15.1.2.5. Strategy Overview
15.1.2.5.1. Marketing Strategy
15.1.3. Novartis AG
15.1.3.1. Overview
15.1.3.2. Product Portfolio
15.1.3.3. Profitability by Market Segments
15.1.3.4. Sales Footprint
15.1.3.5. Strategy Overview
15.1.3.5.1. Marketing Strategy
15.1.4. Pfizer Inc.
15.1.4.1. Overview
15.1.4.2. Product Portfolio
15.1.4.3. Profitability by Market Segments
15.1.4.4. Sales Footprint
15.1.4.5. Strategy Overview
15.1.4.5.1. Marketing Strategy
15.1.5. Sanofi
15.1.5.1. Overview
15.1.5.2. Product Portfolio
15.1.5.3. Profitability by Market Segments
15.1.5.4. Sales Footprint
15.1.5.5. Strategy Overview
15.1.5.5.1. Marketing Strategy
15.1.6. Merck KGaA
15.1.6.1. Overview
15.1.6.2. Product Portfolio
15.1.6.3. Profitability by Market Segments
15.1.6.4. Sales Footprint
15.1.6.5. Strategy Overview
15.1.6.5.1. Marketing Strategy
15.1.7. LEO Pharma A/S
15.1.7.1. Overview
15.1.7.2. Product Portfolio
15.1.7.3. Profitability by Market Segments
15.1.7.4. Sales Footprint
15.1.7.5. Strategy Overview
15.1.7.5.1. Marketing Strategy
15.1.8. Cipla Inc.
15.1.8.1. Overview
15.1.8.2. Product Portfolio
15.1.8.3. Profitability by Market Segments
15.1.8.4. Sales Footprint
15.1.8.5. Strategy Overview
15.1.8.5.1. Marketing Strategy
15.1.9. GlaxoSmithKline plc
15.1.9.1. Overview
15.1.9.2. Product Portfolio
15.1.9.3. Profitability by Market Segments
15.1.9.4. Sales Footprint
15.1.9.5. Strategy Overview
15.1.9.5.1. Marketing Strategy
15.1.10. AstraZeneca
15.1.10.1. Overview
15.1.10.2. Product Portfolio
15.1.10.3. Profitability by Market Segments
15.1.10.4. Sales Footprint
15.1.10.5. Strategy Overview
15.1.10.5.1. Marketing Strategy
15.1.11. Abbott
15.1.11.1. Overview
15.1.11.2. Product Portfolio
15.1.11.3. Profitability by Market Segments
15.1.11.4. Sales Footprint
15.1.11.5. Strategy Overview
15.1.11.5.1. Marketing Strategy
15.1.12. Bayer AG
15.1.12.1. Overview
15.1.12.2. Product Portfolio
15.1.12.3. Profitability by Market Segments
15.1.12.4. Sales Footprint
15.1.12.5. Strategy Overview
15.1.12.5.1. Marketing Strategy
16. Assumptions & Acronyms Used
17. Research Methodology
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Diamond-Blackfan Anemia (DBAAASE) Syndrome Therapeutics Market
