Congenital Hyperinsulinism Treatment Market Snapshot (2023 to 2033)

The global congenital hyperinsulinism treatment market is expected to garner a market value of USD 100 Million in 2023 and is expected to accumulate a market value of USD 179.08 Million by registering a CAGR of 6% in the forecast period 2023 to 2033. The market for Congenital Hyperinsulinism registered a CAGR of 4% in the historical period 2017 to 2022.

Diabetes is a most common health problem causing high blood sugar levels resulting in excessive thirst and large amounts of urine production. It causes secondary health-associated problems such as diabetic ketoacidosis, hyperosmolar hyperglycemic states, and other serious complications (heart attack, stroke, kidney failure, leg amputation) leading to premature death.

The growing number of patients suffering from diabetes will accelerate the market growth rate. Moreover, increasing awareness among physicians and patients about the benefits of Congenital Hyperinsulinism will provide beneficial opportunities for the growth of the Congenital Hyperinsulinism Treatment market.

Report Attribute Details
Expected Market Value (2023) USD 100 Million
Anticipated Forecast Value (2033) USD 179.08 Million
Projected Growth Rate (2023 to 2033) 6% CAGR

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2017 to 2022 Congenital Hyperinsulinism Treatment Market Demand Analysis vs. Forecast 2023 to 2033

According to market research and competitive intelligence provider Future Market Insights- the market for Congenital Hyperinsulinism reflected a value of 4% during the historical period, 2017 to 2022. Various factors such as awareness of wellness and health and the rising geriatric population suffering from diabetes are projected to drive the market growth.

In the years to come, increasing focus by government organizations and private agencies like WHO and pharmaceutical companies to create awareness of Congenital Hyperinsulinism treatment is fuelling the market growth. Thus, the market for Congenital Hyperinsulinism is expected to register a CAGR of 6% in the forecast period 2023 to 2033.

Which are Some Prominent Drivers of the Congenital Hyperinsulinism Treatment Market?

Strong Relation Between Diabetes & Congenital Hyperinsulinism to push the market growth

The increasing prevalence of Congenital Hyperinsulinism disease is one of the biggest drivers of the market. As per studies, Congenital hyperinsulinism affects approximately 1 in 50,000 newborns. This condition is more common in certain populations, affecting up to 1 in 2,500 newborns.

Furthermore, studies suggest that about 60% of babies with HI are diagnosed during the first month of life. An additional 30% will be diagnosed later in the first year and the remainder after that. With early treatment and aggressive prevention of hypoglycemia, brain damage can be prevented. However, brain damage can occur in children with HI if the condition is not recognized or if treatment is ineffective in the prevention of hypoglycemia.

The massive growth in the diabetic population is primarily attributable to rising Congenital Hyperinsulinism rates around the world, as well as sedentary lifestyles defined by poor diets and decreased physical exercise.

Furthermore, a strong relationship between diabetes and Congenital Hyperinsulinism has been proven by certain studies. For instance, NCBI states that β cell failure in type 2 diabetes (T2D) is associated with hyperglycemia, but the mechanisms are not fully understood. Congenital hyperinsulinism caused by glucokinase mutations (GCK-CHI) is associated with β cell replication and apoptosis. Here, we show that genetic activation of β cell glucokinase, initially triggering replication, causes apoptosis associated with DNA double-strand breaks and activation of the tumor suppressor p53.

Considering these in-depth studies, the market is projected to show considerable growth through 2033.

Sabyasachi Ghosh
Sabyasachi Ghosh

Principal Consultant

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What are the Challenges Faced by the Congenital Hyperinsulinism Treatment Market?

Expensive Cost of Treatment to restrict Market Growth

The expensive treatment of Congenital Hyperinsulinism, less awareness of Congenital Hyperinsulinism disease, and insubstantial treatment options are hampering the market growth.

Region-Wise Insights

How is the Market for Congenital Hyperinsulinism Treatment Turning Out in the Asia Pacific Region?

Improvement in healthcare spending propelling growth of Congenital Hyperinsulinism in Asia Pacific

The Asia Pacific is expected to exhibit a significant growth rate of all regions over the forecast period, with a CAGR of 5% during the forecast period. The growth is owed to increased awareness, significant increases in healthcare spending, and a rising frequency of Congenital Hyperinsulinism treatment in the region. Asia Pacific is an emerging market due to the increase in point care approach to health & care. An increasing number of hospitals in India and China makes a promising market for the treatment market worldwide.

What are the Factors Boosting the Market for Congenital Hyperinsulinism in North America?

Technological Advancements Shaping Landscape for Congenital Hyperinsulinism in North America

North America is anticipated to acquire a market share of about 25% in the forecast period. This growth is attributable to the rising prevalence of the condition in the region. Furthermore, due to the presence of leading technological advancements in the healthcare sector and healthcare facilities with the advancements in technology, efficient treatments are being introduced.

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Category-Wise Insights

By Application, Which End-User is Likely to Account for the Highest Share?

Hospitals to take the lead and drive market growth

The application segment has been divided into hospitals, retail pharmacies, and Ambulatory Surgical Centres. According to the FMI analysis, Hospitals account for the largest market share. The requirement for several hospital stays and visits during Congenital Hyperinsulinism treatment facilitates the growth of this segment.

Start-ups in the Congenital Hyperinsulinism Treatment Market

Key start-up players in the Congenital Hyperinsulinism Treatment Market are-

  • Xinvento, a biotech company aiming to improve the lives of those with Congenital Hyperinsulinism, announced the completion of a seed funding round. Xinvento was founded in 2021 by CEO Claudine van der Sande, the driving force behind the company, who has a son diagnosed with Congenital Hyperinsulinism (CHI). This seed funding will enable Xinvento to design and test its proprietary molecules in the relevant pre-clinical models to identify potential drug candidates.
  • Rezolute (formerly Antriabio) is a biopharmaceutical company, developing drugs for metabolic and orphan diseases. The lead candidate, RZ358 is an insulin receptor antagonist monoclonal antibody for congenital hyperinsulinism (CHI) and has an orphan drug designation(Phase 2). Another molecule, AB101 is a once-weekly injectable basal insulin for diabetes management (in Phase 1). Also developing plasma kallikrein inhibitors (PKI) for diabetic macular edema (DME) & hereditary angioedema (HAE). In Dec 2017, the company entered into a license agreement with Xoma which gives Rezolute exclusive global rights to develop and commercialize RZ358, formerly called XOMA 358.

Market Competition

Key players in the Congenital Hyperinsulinism Treatment Market are Eli Lilly, Novo Nordisk, Novartis AG, Rezolute, Inc., Eiger BioPharmaceuticals., Zealand Pharma A/S, Hanmi Pharmaceutical Co., Ltd., Crinetics Pharmaceuticals, Inc., AmideBio LLC, and Xeris Pharmaceuticals, Inc.

  • In September 2022, Novo Nordisk and Microsoft entered a new strategic collaboration to combine Microsoft’s computational services, cloud, and artificial intelligence (AI) with Novo Nordisk’s drug discovery, development, and data science capabilities. Through the partnership, Microsoft is providing AI technology, foundational science models, and expertise and is working alongside Novo Nordisk’s data scientists and domain experts from early research and development areas to accelerate Novo Nordisk’s Research and Development.

Report Scope

Report Attribute Details
Market Value in 2023 USD 100 Million
Market Value in 2033 USD 179.08 Million
Growth Rate CAGR of 6% from 2023 to 2033
Base Year for Estimation 2022
Historical Data 2017 to 2022
Forecast Period 2023 to 2033
Quantitative Units Revenue in USD Million and CAGR from 2023 to 2033
Report Coverage Revenue Forecast, Volume Forecast, Company Ranking, Competitive Landscape, Growth Factors, Trends, and Pricing Analysis
Segments Covered Procedure, Application, Region
Regions Covered North America; Latin America; Europe; Asia Pacific; Middle East and Africa(MEA)
Key Countries Profiled USA, Canada, Brazil, Argentina, Germany, United Kingdom, France, Spain, Italy, Nordics, BENELUX, Australia & New Zealand, China, India, ASEAN, GCC Countries, South Africa
Key Companies Profiled Eli Lilly, Novo Nordisk, Novartis AG, Rezolute, Inc., Eiger BioPharmaceuticals., Zealand Pharma A/S, Hanmi Pharmaceutical Co., Ltd., Crinetics Pharmaceuticals, Inc., AmideBio LLC, Xeris Pharmaceuticals, Inc
Customization Available Upon Request

Key Segments Profiled in the Congenital Hyperinsulinism Industry Survey

Treatment Method:

  • Drug Therapy
    • Diazoxide
    • Octreotide
    • Glucagon
    • Others
  • Surgery

Application:

  • Hospitals
  • Clinics
  • Others

Region:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East and Africa(MEA)

Frequently Asked Questions

What is the Congenital Hyperinsulinism Treatment Market CAGR for 2033?

The congenital hyperinsulinism treatment market CAGR for 2033 is 6%.

How Big Will the Congenital Hyperinsulinism Treatment Market by 2033?

The market is estimated to reach USD 179.08 million by 2033.

How Key Players are Developing the Congenital Hyperinsulinism Treatment Market?

Key congenital hyperinsulinism treatment market players are introducing new and innovative therapies.

What is the Current Congenital Hyperinsulinism Treatment Market Valuation?

The market is estimated to secure a valuation of USD 100 million in 2023.

Who are the Three Key Players in the Congenital Hyperinsulinism Treatment Market?

Zealand, Rezolute, and Xeris are the three key congenital hyperinsulinism treatment market players.

Table of Content
	1. Executive Summary
	2. Market Overview
	3. Market Background
	4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033
	5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Treatment Methods
		5.1. Drug Therapy
			5.1.1. Diazoxide
			5.1.2. Octreotide
			5.1.3. Glucagon
			5.1.4. Others
		5.2. Surgery
	6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Application
		6.1. Hospitals
		6.2. Clinics
		6.3. Others
	7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region
		7.1. North America
		7.2. Latin America
		7.3. Europe
		7.4. Asia Pacific
		7.5. Middle East and Africa (MEA)
	8. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
	9. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
	10. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
	11. Asia Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
	12. MEA Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
	13. Key Countries Market Analysis
	14. Market Structure Analysis
	15. Competition Analysis
		15.1. Eli Lilly
		15.2. Novo Nordisk
		15.3. Novartis AG
		15.4. Rezolute, Inc.
		15.5. Eiger BioPharmaceuticals
		15.6. Zealand Pharma A/S
		15.7. Hanmi Pharmaceutical Co., Ltd.
		15.8. Crinetics Pharmaceuticals, Inc.
		15.9. AmideBio LLC
		15.10. Xeris Pharmaceuticals, Inc.
	16. Assumptions & Acronyms Used
	17. Research Methodology
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