The global bone regeneration market is set to witness a valuation of USD 5,380.75 million in 2023, and further expand at a CAGR of 3.8% to reach USD 7,827.8 million by 2033. In terms of product type, bone graft substitutes led the market with a share of 81.2% in 2022.
The need for reconstructive surgery coupled with the prevalence of bone diseases across the globe has improved the demand for bone regenerative techniques. Statistics show that nearly 10% of men and 18% of women above 60 years have symptomatic osteoarthritis.
Apart from this, a massive spike in bone injuries and hip fractures, especially among sports enthusiasts, has resulted in increased demand for bone regeneration surgeries.
Alternatives to bone grafts are used to cure delayed fracture unions, fuse the spine, repair bone abnormalities, and fill cavities brought on by a variety of factors. The substance is derived from a range of sources, including synthetics, bone void fillers, bone morphogenetic proteins, demineralized bone matrix, autografts, allografts, and others.
Globally, pediatric deformity, degenerative diseases, musculoskeletal oncology, spinal deformity, and cases of trauma and injury comprise the bulk of orthopedic problems. These problems are especially noticeable in developing economies such as India, China, and Brazil.
The market for bone regeneration is hence predicted to expand as more people develop musculoskeletal problems or disorders. The global market is expected to grow at a CAGR of 3.8% over the forecast period.
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Degenerative joint illnesses are becoming more common, which is aiding the growth of the industry. In the absence of treatment for the illness, numerous osteoarthritis patients develop extensive joint deterioration.
Surgery utilizing bone replacements and transplants is essential to halt osteoarthritis-related progressive joint degeneration. Improvements in biomaterial and tissue engineering, according to the American College of Rheumatology, create new opportunities for incorporating surgical techniques in osteoarthritis.
According to healthcare professionals, the body's natural bone-healing mechanisms are aided by low-level electrical fields. Currently, this application is using the same technology. Researchers are leveraging advanced healthcare technologies to make additional strides, such as developing new strategies for promoting bone regeneration or making enhancements to the current devices.
Further, with a growing number of knee surgeries, healthcare professionals are developing advanced procedures and techniques to make the procedure less invasive and to increase the healing time. As per the American Academy of Orthopaedic Surgeons, over 6 million have undergone total knee arthroplasty in 2010 and the number has risen dramatically over the past decade.
For instance, in August 2022, OSSIO Inc., a leading orthopedic fixation technology company announced the launch and first commercial use of OSSIOfiber suture anchors in the USA This is accessible and can be used as bio-integrative implants in foot/ankle, and knee, shoulder, and elbow surgery.
Patients with non-union or delayed union of a bone fracture are usually advised to try traditional physiotherapy, yoga, or Ayurveda treatments. Several reviews on the therapy of fractures have incorrectly classed electrical and ultrasonic treatment as contraindications.
Chiropractors represent a huge threat to the industry's ability to continue running as they are the leading alternative medical profession. The emergence of more potent alternative therapies hinder the growth of the bone regeneration industry.
Even though various research is being carried out to evaluate the efficacy of bone growth stimulator devices, the amount of scientific data currently accessible is insufficient to address their magnitude. According to an IJO review, it is challenging to do meta-analyses on the effectiveness of bone growth stimulator devices due to the variability of the clinical study designs for such devices.
With robust research and development, numerous research programs are attempting to solve device-related constraints. However, there are several shortcomings with the various devices on the market, and they must adhere to strict rules set forth by the regulatory bodies of distinct nations. The device is inadequate in several areas, including the shelf life and biocompatibility of the materials.
| Attributes | Details |
|---|---|
| Bone Regeneration Market CAGR (2023 to 2033) | 3.8% |
| Bone Regeneration Market Size (2023) | USD 5,380.75 million |
| Bone Regeneration Market Size (2033) | USD 7,827.8 million |
Principal Consultant
As per Future Market Insights (FMI), the bone regeneration market held approximately 13.3% of the overall USD 37,200 million global orthopedics market in 2021. The bone regeneration industry expanded at a CAGR of 2.4% from 2018 to 2022 due to the increasing incidence of bone fractures and delayed bone healing.
Fractures are treated using a variety of techniques, such as surgery, amputations, allografts, and synthetic bone grafts. Low-intensity ultrasound stimulation and electrical bone growth stimulation are two examples of non-invasive treatments.
These devices speed up the healing process and are approved by regulatory authorities such as the United States Food and Drug Administration (FDA). Additionally, the reimbursement guidelines for bone growth stimulators have been updated by CMS and Medicare. Higher adoption rates of non-invasive techniques have also resulted in cost-effective methods, promoting the adoption of bone regenerative techniques.
Hence, players are introducing advanced products and technological innovations to leverage untapped market opportunities. Top manufacturers of bone regenerations products are expanding the value chain to integrate into the market of developing economies.
The increasing prevalence of patients with one or more comorbidities, such as degenerative joint diseases, osteoporosis, osteoarthritis, etc., make the bones brittle and susceptible to fractures and delayed healing. This is expected to be a prominent driver of the global bone regeneration sector in the coming years.
| Country | Market Share (2022) |
|---|---|
| United States | 25.5% |
| Germany | 8.6% |
| Japan | 3.3% |
The USA dominated the North American market with a total share of about 73.7% in 2021 and is expected to experience the same growth over the forecast period. The USA is considered to be the most attractive market due to the increased prevalence of joint illnesses, resulting in an increase in surgical treatments.
The market for bone regeneration is expanding as a result of significant investment in Research and Development activities and the introduction of new products in the area.
According to the American Academy of Orthopedic Surgeons, in the USA by 2030, the number of total knee arthroplasty surgeries is expected to reach 3 million. Around 4.3 million spinal fusions are performed in the United States every year. This is expected to create lucrative growth prospects in the United States bone regeneration business over the upcoming decade.
Germany is set to exhibit a CAGR of nearly 3.7% in the Europe market during the forecast period. Growth is primarily underpinned by increasingly available customized bone grafts and substitute treatments.
In Germany, 17.9% of adults over 18 reported having osteoarthritis, with women experiencing a higher frequency (21.8%) than men (13.9%), according to 2017 data from The Journal of Health Monitoring. On the other hand, favorable reimbursement policies provided by organizations are pushing patients to opt for cost-effective bone regenerative treatments, fueling growth in the market.
China held a 50.3% share in the East Asia bone regeneration market in 2022 and is projected to increase at a CAGR rate of 4.6% during the forecast period. With the developing healthcare system in China, healthcare professionals are witnessing a paradigm shift in regenerative medicine technology.
The advent of 3D structures and non-invasive bone grafting procedures has transformed the face of China's bone regeneration market. Further, with the growing prevalence of bone disorders, even in children and adolescents has led to an uptake in bone regenerative product sales. Backed by these factors, the demand in China is expected to surge over the forecast period.
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Bone graft substitutes project lucrative growth at a CAGR of 4.1% during the forecast period, and led the market with a share of around 81.2% in 2022. Bone graft substitutes are used to repair delayed fracture unions, fuse the spine, fill voids caused by a variety of conditions, and bridge bone abnormalities.
The bone graft substitute has a high likelihood of successful bone fusion making it the most profitable product available on the market for bone regeneration.
Trauma cases held a revenue share of 22.8% in 2022 and are expected to increase at a CAGR of 2.6% by 2033. The leading cause of death for those under the age of 65 is trauma. Additionally, injury-related mortality is a significant global public health burden, driving the market.
Emergency rooms are a sensitive indicator of the impact generated by traumatic injury. The market is anticipated to grow between 2023 and 2033 as bone graft substitute plays a significant role in trauma cases.
Due to the availability of products and therapies for treating joint problems, hospitals currently hold the top position in the bone regeneration market with a 49.1% market share.
Throughout the forecast period, they are expected to maintain this position while growing at a CAGR of 3.6%. As more patients are admitted to hospitals for the treatment of musculoskeletal injuries and diseases, the market for bone regeneration is anticipated to expand.
Growth in the market is facilitated by the availability of cutting-edge medical equipment with better efficiency and technology, as well as by qualified personnel and healthcare experts.
Numerous patients are drawn to hospitals because of the existence of cutting-edge medical technology to receive treatment and experience the most satisfaction and comfort. As a result, hospitals dominate the market for bone regeneration compared to other end users.
Key competitors in the bone regeneration sector are focusing on collaborations, product launches, and expansion to achieve a dominant position in the market.
With the use of these strategies, market participants can increase the number of products they offer and their market penetration. As a result, they have seen a rise in their overall revenue share in the global market for bone regeneration.
Given below are a few examples of the key strategies followed by the manufacturers:
Key Players
The bone regeneration market CAGR for 2033 is 3.8%.
The market is estimated to reach US$ 7,827.8 million by 2033.
North America, Europe, and Asia-Pacific are the top 3 countries leading the market.
The market is estimated to secure a valuation of US$ 5,380.75 million in 2023.
India, Japan, and China dominate the Asian market.
1. Executive Summary 2. Market Overview 3. Market Background 4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033 5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Product 5.1. Demineralized Bone Matrix (DBM) 5.2. Xenograft 5.3. Autografts 5.4. Synthetic Bone Graft 5.5. Bone Morphogenetic Protein (BMP) 5.6. Non-Invasive Electrical Bone Growth Stimulators 5.7. Invasive Electrical Bone Growth Stimulators 6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Application 6.1. Osteoarthritis (OA) 6.2. Osteoporosis 6.3. Rheumatoid Arthritis (RA) 6.4. Spinal Disorders 6.5. Dentistry 6.6. Craniomaxillofacial (CMF) 6.7. Trauma Cases 7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Age Group 7.1. Pediatric 7.2. Adults 7.3. Geriatric 8. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By End User 8.1. Hospitals 8.2. Orthopedic Clinics 8.3. Ambulatory Surgical Centers 9. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region 9.1. North America 9.2. Latin America 9.3. Western Europe 9.4. Eastern Europe 9.5. South Asia and Pacific 9.6. East Asia 9.7. Middle East and Africa 10. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 11. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 12. Western Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 13. Eastern Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 14. South Asia and Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 15. East Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 16. Middle East and Africa Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 17. Key Countries Market Analysis 18. Market Structure Analysis 19. Competition Analysis 19.1. Medtronic plc. 19.2. Stryker Corporation 19.3. DePuy Synthes Inc. 19.4. Integra Lifesciences Holdings Corporation 19.5. Zimmer Biomet Holdings Inc. 19.6. Xtant Medical Holdings Inc. 19.7. Arthrex Inc. 19.8. Baxter International Inc. 19.9. Musculoskeletal Transplant Foundation 19.10. Smith & Nephew Inc. 19.11. Orthofix Holdings Inc. 19.12. Nuvasive Inc. 19.13. Allosaurus 19.14. NovaBone Products LLC 19.15. BonAlive Biomaterials Ltd. 19.16. Sigma Graft Biomaterials 19.17. RTI Surgical 19.18. Institut Straumann AG 19.19. Exactech Inc 19.20. A.B. Dental Devices Ltd 20. Assumptions & Acronyms Used 21. Research Methodology
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Bone Regeneration Market
