Axial Spondyloarthritis Management Market Outlook 2025 to 2035

The axial spondyloarthritis management market will bevalued at USD 4.90 billion in 2025. As per FMI's analysis, axial spondyloarthritis management will grow at a CAGR of 5.1% and reach USD 8.06 billion by 2035.

The axial spondyloarthritis industry for the management of axial spondyloarthritis in 2024 saw modest growth, underpinned primarily by growing biologic uptake, including IL-17 inhibitors (secukinumab, ixekizumab) and TNF-α inhibitors, based on their established capacity to curb inflammation and delay the progression of the condition. Diagnostic techniques also made their contributions, including the greater application of MRI and HLA-B27 tests, promoting earlier and correct identification, particularly for non-radiographic products.

Moreover, strategic alliances between drug firms and rheumatology clinics enhanced treatment availability in emerging industries, including Asia-Pacific and Latin America. The year also witnessed advances in drug development, as innovative JAK inhibitors such as upadacitinib gained momentum, although they encountered price pressure from biosimilar competition.

Gazing into the future towards 2025 and beyond, the industry will undergo changes with heightened biosimilar competition, mainly for TNF-α inhibitors, that will reduce prices and boost affordability. Personalized medicine will gain prominence, using biomarker-guided treatments and AI-guided treatment optimization to enhance outcomes. The emerging economies of India, China, and Brazil are set to grow faster due to better healthcare infrastructure and increased disease awareness.

In addition to pharmaceutical interventions, non-pharmacological treatments-like digital physiotherapy apps and wearable pain devices-will continue to support conventional methods. The industry is expected to break the USD 8 billion mark by 2035, driven by an increasing elderly population, sophisticated diagnostics, and new-generation biologics.

Key Metrics

Metrics Values
Industry Size (2025E) USD 4.90 billion
Industry Value (2035F) USD 8.06 billion
Value-based CAGR (2025 to 2035) 5.1% 

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FMI Survey on Axial Spondyloarthritis Management Industry

FMI Survey Findings: According to Stakeholder Insights

(Surveyed Q4 2024, n=500 stakeholders-rheumatologists, pharmaceutical leaders, payers, and patients-USA, Western Europe, Japan, and South Korea)

Stakeholders' Top Priorities

Efficacy & Safety of Therapies: 85% of stakeholders worldwide identified biologic efficacy and long-term safety as their number one priority.

Early Diagnosis & Intervention: 78% underscored the importance of improved diagnostic tests (MRI, biomarker testing) to decrease diagnostic lag times (5-7 years currently in most areas).

Cost & Accessibility: 72% identified drug price as the key obstacle, particularly for biologics.

Regional Variance:

USA: 68% ranked insurance coverage and reform of prior authorization as top priorities due to repeated payer limitations.

Western Europe: 82% named cost-effectiveness requirements (e.g., NICE guidelines) as determinative in adopting treatment.

Japan/South Korea: 59% were concerned with government reimbursement policies, with Japan preferring JAK inhibitors because of price flexibility.

Uptake of Advanced Therapies

Large Variance in Treatment Choices:

USA: 63% of rheumatologists prescribed IL-17 inhibitors (secukinumab, ixekizumab) as first-line biologics, ahead of TNF-α blockers (48%).

Western Europe: 55% utilized biosimilars (e.g., adalimumabbiosimilars) because of cost pressures, with Germany (71% uptake) leading the way.

Japan: Only 28% embraced newer biologics, attributing this to strict price controls and oral DMARD preference.

South Korea: 41% invested in personalized medicine (e.g., HLA-B27 subtyping) to inform therapy choice.

ROI Perspectives:

US/EU: 75% considered biologics "worth the cost" for severe products, but 42% in Japan used NSAIDs + physiotherapy due to budget limitations.

Drug Class Preferences

Consensus:

Biologics Dominance: 68% of specialists preferred biologics for moderate-to-severe cases.

Regional Variance:

USA: TNF-α inhibitors (e.g., Humira, Enbrel) continued to dominate (52%), but IL-17 inhibitors increased to a 38% share.

Western Europe: Biosimilars took 60% of the TNF-α industry, fueled by EU tendering policies.

Japan/South Korea: JAK inhibitors (upadacitinib) picked up momentum (45%) with oral dosing and reduced storage costs.

Price Sensitivity & Reimbursement Challenges

Shared Challenges:

89% mentioned the high list prices of biologics (e.g., 50K- 50 K-70K/year in the USA) as unsustainable.

Prior Authorization Delays: 65% of USA clinicians reported 3+ weeks for approval.

Regional Differences:

USA/Western Europe: 60% accepted outcome-based pricing (e.g., pay-for-performance contracts).

Japan/South Korea: 78% depended on government price caps, with 55% of patients suffering out-of-pocket burdens.

South Korea: 40% favored local biosimilars (40% cheaper than originators).

Pain Points in the Value Chain

Manufacturers:

USA: 58% had difficulty with FDA approval delays for novel mechanisms (e.g., IL-23 inhibitors).

Western Europe: 50% encountered HTA (health technology assessment) barriers (e.g., IQWiG in Germany).

Japan: 62% mentioned delayed pricing negotiations with NHI.

Clinicians:

USA: 47% reported infusion clinic staff shortages.

Western Europe: 53% had difficulty with step-therapy requirements (ailing NSAIDs before biologics).

Japan: 45% did not have specialized rheumatology centers in rural regions.

Patients:

USA: 51% mentioned copay accumulators as a financial burden.

EU: 38% experienced lengthy wait times for biologics.

Asia: 60% had restricted access to physical therapy.

6Priorities for Future Investment

Alignment:

80% of pharma leaders invested in next-generation biologics (IL-23, dual TNF/JAK inhibitors).

70% invested in digital health integrations (e.g., AI-facilitated treatment optimization).

Divergence:

USA: 65% invested in direct-to-patient support programs (copay assistance, telehealth).

Western Europe: 55% invested in real-world evidence (RWE) generation for HTA compliance.

Japan/South Korea: 48% invested in low-cost biosimilars and generics.

Regulatory Impact

USA: 70% reported that ICER cost-effectiveness reviews impacted payer restrictions.

Western Europe: 85% saw EU JCAs as an industry barrier/growth driver.

Japan/South Korea: 30% believed that regs had little or no impact due to weak treatment guideline enforcement.

Conclusion: Key Takeaways

Global Consensus: Biologic efficacy, cost barriers, and diagnostic delays are all global challenges.

Regional Strategies:

USA: High-end biologics + pay negotiations rule.

Western Europe: Biosimilars + RWE-driven prices rule.

Asia: Cost control (JAKs, domestic biosimilars) is essential.

Strategic Insight:

No single approach works-success requires regional adaptation (e.g., USA industry access teams, EU HTA strategies, Asia pricing flexibility).

Government Regulations on Axial Spondyloarthritis Management Market

Country/Region Key Policies, Regulations & Mandatory Certifications
USA
  • FDA Approval : Mandatory for all biologics, JAK inhibitors, and biosimilars.
  • ICER Reviews : Cost-effectiveness assessments influence payer coverage.
  • Affordable Care Act (ACA) : Expands access but imposes prior authorization hurdles.
  • 340B Drug Pricing Program : Discounts for hospitals, affecting manufacturer pricing.
  • Risk Evaluation & Mitigation Strategies (REMS) : Required for JAK inhibitors (e.g., upadacitinib ).
European Union
  • EMA Approval : Mandatory for industry entry.
  • EU Joint Clinical Assessment (JCA) : Post-2025, required for pricing/reimbursement.
  • Biosimilar Substitution Laws : Vary by country (e.g., automatic substitution in Germany).
  • HTA Requirements : NICE (UK), IQWiG (Germany), HAS (France) demand cost-effectiveness.
  • EU Pharma Legislation 2023 : Faster approvals but stricter post- industry surveillance.
Japan
  • PMDA Approval : Required for all drugs.
  • NHI Pricing : Strict biannual price cuts (up to 7% ).
  • Early Reimbursement Incentives : For innovative drugs (e.g., JAK inhibitors).
  • GCP/GLP Certification : Mandatory for clinical trials.
South Korea
  • MFDS Approval : Mandatory for biologics/biosimilars.
  • Reimbursement Listing : Requires cost-utility analysis.
  • Biosimilar Promotion Policy : Government mandates biosimilar use in public hospitals.
  • Local Clinical Trials : Often required for approval (vs. foreign data).
China
  • NMPA Approval : Mandatory, with accelerated pathways for "urgent need" drugs.
  • NRDL Listing : National Reimbursement Drug List negotiations determine access.
  • Volume-Based Procurement (VBP) : Forces 50-90% price cuts for included drugs.
  • Local Manufacturing : Encouraged for biologics (e.g., adalimumab biosimilar).

Market Analysis

The worldwide axial spondyloarthritismanagement industry is expanding steadily (5.1% CAGR), spurred on by the increasing prevalence of the disease, biologic innovation, and enhanced diagnostics-but cost constraints and payer limitations are reconfiguring access.

Biologic/biosimilar manufacturers (e.g., Novartis, AbbVie) will gain in the USA/EU, while JAK inhibitors and regionally manufactured biosimilars take hold in Asia. Japanese and Chinese patients in cost-containment industries can expect to experience restricted access to high-end treatments as a consequence of aggressive price policies.

Top 3 Strategic Imperatives for Stakeholders

Speed Up Biosimilar & Next-Generation Biologic Development

Action: Invest in biosimilars (TNF-α, IL-17 inhibitors) and new biologics (IL-23, dual JAK/TNF inhibitors) to gain share in cost-sensitive geographies (EU, Asia) while protecting premium biologics in the USA through outcomes-based pricing.

Optimize Market Access via Payer & Regulatory Partnerships

Action: Enhance HTA/real-world evidence (RWE) capacity in Europe and copay assistance schemes in the USA to overcome reimbursement challenges. In Asia, collaborate with local manufacturers to deal with pricing pressures (e.g., China's VBP, Japan's NHI).

Develop Digital & Non-Pharma Solutions

Action: Invest in or collaborate with digital health startups (tele-rheumatology, AI diagnostics) and physical therapy platforms to develop integrated care models-essential for value-based healthcare system differentiation (EU, USA ACOs).

Axial Spondyloarthritis Management Market Top3 Strategic Imperative For Stakeholders

Top 3 Risks Stakeholders Should Monitor

Risk Probability/Impact
Aggressive Biosimilar Price Erosion (Especially in EU/Asia) High
Stricter Cost-Effectiveness Regulations (e.g., ICER in USA, EU JCA) Medium-High
Supply Chain Disruptions for Biologics (e.g., cold chain, API shortages) Medium

Executive Watchlist

Priority Immediate Action
Biosimilar Penetration Launch EU/USA biosimilar pricing pilots with payers (e.g., outcomes-based contracts for adalimumab biosimilars ).
Digital Health Integration Partner with 2-3 tele-rheumatology platforms to pilot AI-driven treatment adherence tools (focus on Germany & USA Medicare).
JAK Inhibitor Reimbursement Strategy Secure accelerated JAK inhibitor ( upadacitinib ) formulary placements in Japan/South Korea via NHI/KFDA negotiations.
Emerging Localization Initiate joint ventures in China/India for local biosimilar production (target 20% cost reduction vs. imports).

For the Boardroom

To stay ahead, companies need a strategic imperative that is clear: Move from a reactive to proactive industry strategy by implementing a region-by-region, dual-track growth strategy in the next 12 months. In Europe, seize biosimilar tailwinds immediately by pre-emptively contracting with leading payers with the goal of achieving a 60% share of TNF-α biosimilars by 2025 through bundled service packages that meet stringent HTA requirements.

In the USA, counteract on pricing pressures by speeding up commercialization of next-gen IL-17/23 inhibitors, differentiating them through integrated digital health offerings (e.g., AI-driven adherence monitoring) to drive premium pricing and counter payer limits.

Segment-wise Analysis

By Types

Ankylosing Spondylitis therapies are more prevalent than those of non-radiographic axial spondyloarthritis, owing to more defined diagnostic standards and developed treatment protocols. AS, with overt radiographic damage, has been a well-defined condition for many years and is therefore associated with clear treatment protocols and more extensive insurance coverage for advanced treatments such as biologics (e.g., TNF-α and IL-17 inhibitors). Conversely,with no radiographic evidence but the same symptoms-is plagued by diagnostic difficulties and, therefore, tends to experience delayed or missed diagnoses.

By Drug Class

Non-steroidal anti-inflammatory drugs are most commonly used first-line therapy for axial spondyloarthritis, both ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis, because they effectively treat pain and inflammation, are easy to get, and are less expensive than others.

NSAIDs such as ibuprofen and naproxen are used by clinicians to treat early disease because they achieve quick relief from symptoms, can be administered orally, and are well-established to be safe when monitored. However, glucocorticoids (e.g., prednisone) are employed infrequently on a chronic basis in products for modest efficacy regarding spine symptoms and with substantial side effects (e.g., osteoporosis, diabetes) but could be considered on a short-term basis to address peripheral joint flare.

By End-User

Hospitals are the most common healthcare environment for axial spondyloarthritis care, being the main site of diagnosis, specialist treatment, and complex care coordination. As these are tertiary care hospitals, they provide vital infrastructure for high-level imaging (MRI/X-rays), rheumatologists, and infusion centers for biologic drugs - all indispensable for products'long-term control.

They also deal with severe cases involving multidisciplinary management, including possible surgical options for advanced ankylosing spondylitis. Although clinics (specifically rheumatology specialty clinics) offer critical outpatient services, they tend not to have the full range of resources available at hospitals. Rehabilitation facilities have a complementary role based on physical therapy, and academic research centers stimulate treatment innovation but address limited volumes of patients directly.

Country-wise Analysis

Countries CAGR
USA 7.5%
UK 6.8%
France 8.7%
Germany 8.8%
Italy 7.0%
South Korea 11.7%
Japan 10.3%
China 12.5%

USA

The United States is likely to experience a strong CAGR of 7.5% in the axial spondyloarthritis management market during 2025 to 2035. This is fueled by a high incidence of products, sophisticated healthcare infrastructure, and heavy investments in R&D. The USA industry is supported by the presence of top pharma players and a high emphasis on novel biologic therapies. Moreover, growing awareness and early detection are driving growth.

Personalized medicine and the incorporation of telemedicine services are also improving patient treatment and management outcomes. Government efforts to lower healthcare costs and enhance patients' access to sophisticated treatments further boost growth. University-industry collaborations are promoting the creation of innovative therapeutics, making America a major competitor in the global industry. ​

UK

The UK's industry for the management of axial spondyloarthritis is anticipated to grow at a CAGR of 6.8% in the forecast period. Drivers of this growth are a well-established National Health Service (NHS), rising patient awareness, and the presence of sophisticated treatment options. The UK's focus on research and development, coupled with favorable regulatory environments, allows for the introduction of new therapies.

Patient advocacy organizations are important in raising awareness and encouraging early diagnosis, which is important for successful disease management. The convergence of digital health technology and telemedicine is enhancing the access of patients to healthcare services, particularly in rural locations. Additionally, the government-private sector collaborations are bolstering the general healthcare infrastructure, thus making the UK an emerging industry for the management of products.

France

France is expected to see a CAGR of 8.7% during the axial spondyloarthritis management market period from 2025 to 2035. This expansion is due to a robust healthcare system, a growing prevalence of products,and healthcare innovation support through government efforts. France's focus on research and development, especially rheumatology research, has resulted in the launch of advanced biologic therapies.

The universal healthcare coverage of France makes these therapies accessible to patients, further boosting growth. In addition, partnerships between pharmaceutical firms and academic institutions are promoting the creation of new therapeutics.

The availability of patient organizations that are pushing for improved disease awareness and management also boosts growth. France's strategic emphasis on personalized medicine and incorporation of digital health solutions are anticipated to improve patient outcomes and propel the management industry.

Germany

Germany's axial spondyloarthritis treatment market will expand at a CAGR of 8.8% from 2025 to 2035. The nation's sophisticated healthcare infrastructure, combined with a high incidence of products, fuels this expansion. Germany has a robust pharmaceutical sector and is dedicated to medical research, which results in the creation and implementation of new treatment methods. The availability of specialized rheumatology centers and skilled healthcare practitioners ensures proper management of the disease.

Government initiatives favoring healthcare innovation and access to advanced treatments further strengthen the industry. The emphasis of Germany on incorporating digital health technologies and personalized medicine strategies is also improving patient care and treatment outcomes. Public-private partnerships are spurring new therapeutic development, making Germany a leader in the European axSpA industry.

Italy

Italy is expected to register a CAGR of 7.0% during the forecast period in the axial spondyloarthritis management market. The aging population in the country, rising incidence of axSpA, and advancements in healthcare services are driving this growth. Italian participation in cross-border clinical trials and research agreements enhances access to innovative treatments. Government emphasis on strengthening healthcare facilities and patient accessibility to advanced therapy encourages growth.

The involvement of patient support organizations creating axSpA awareness and encouraging early detection also proves significant in optimal disease management. Italy's focus on combining digital health solutions and telemedicine services is enhancing patient care and treatment compliance. Academic-industrial partnerships are supporting the formation of new drugs, making Italy an important European landscape for the management of axSpA.

South Korea

South Korea's industry for axial spondyloarthritis management will grow at an impressive CAGR of 11.7% during the period 2025 to 2035. This fast-paced growth is fueled by rising healthcare spending, a growing prevalence of axSpA, and the evolving state of medical technology. South Korea's strong healthcare infrastructure and government policies favouring medical innovation and research drive the advancement and implementation of advanced treatments.

The digitalization of health technologies and telemedicine services in the country, through initiatives such as the provision of data-enabled infrastructure and payments for care, promotes patient access to care, particularly in rural locations. In addition, partnerships between local and foreign drug firms are driving the launch of new biologic treatments. Personalized medicine and patient-centric treatment are South Korea's priorities, which will enhance treatment outcomes and propel the axSpA management industry.

Japan

Japan's axial spondyloarthritis treatment industry is projected to grow at a CAGR of 10.3% during the period 2025 to 2035. This growth is driven by Japan's aging population, rising incidence of autoimmune diseases, and advances in medical technology. Japan is the hub of some of the world's top-ranked pharmaceutical and biotechnology companies, which are investing significantly in creating new biologics and targeted therapies for axSpA.

The strong healthcare system in the country, along with the government-sponsored push for earlier diagnosis and treatment, also benefits growth. Precision medicine also led the charge in Japan with the genetic and biomarker-based therapeutic development of custom-tailored therapies for patients suffering from axSpA. Artificial intelligence-integrated diagnostics and treatment planning are optimizing treatment efficiency.

China

China's axial spondyloarthritis (axSpA) treatment industry is expected to expand at a staggering CAGR of 12.5% during the period 2025 to 2035. This high growth is fueled by a growing incidence of autoimmune disorders, increasing healthcare spending, and a heightened focus on biotechnology and novel therapeutics. With a huge and aging population, China is one of the biggest potential industries for axSpA treatment.

The government of China has been proactively encouraging healthcare reforms, enhancing access to cutting-edge therapies, and prompting domestic pharmaceutical firms to produce biologic treatments. The development of healthcare infrastructure, such as rheumatology centers, is enhancing disease management nationwide. Additionally, China's robust investment in biopharmaceuticals is promoting the creation of biosimilars and novel biologic drugs for axSpA.

Market Share Analysis

Novartis (Cosentyx)-Leads with ~30% (7-9% CAGR) as the top IL-17 inhibitor, driven by long-term efficacy and international expansion.

AbbVie (Skyrizi)-Branded drug with the highest growth rate (12-15% CAGR), taking 18-22% share as the first IL-23 inhibitor for axSpA in EU/USA.

UCB (Bimzelx)-Growing at 10-13% CAGR (15-18% share) with best-in-class IL-17A/F efficacy and nr-axSpA approvals.

Eli Lilly (Taltz)-Maintains 14-17% share (6-8% CAGR) with cost-effective IL-17 subcutaneous dosing.

J&J (Tremfya)-Remains at 5-8% share (3-5% CAGR) after unsuccessful Phase 3 trials restricted its axSpA application.

Pfizer (Xeljanz)-Drops to <5% share (-5% to -10% CAGR) following EU withdrawal due to safety concerns.

Biosimilars (Amgen/Celltrion)-Dominate 20-25% share (4-6% CAGR) as TNF-α price wars escalate, particularly in Europe.

Key Players

  • AbbVie
  • Pfizer
  • Amgen
  • Janssen Biotech
  • Pozen
  • Iroko Pharmaceuticals
  • Syntex Pharmaceuticals
  • Horizon Pharma
  • Eli Lilly and Company
  • Kyowa Kirin
  • Celgene
  • Inmagene Biopharmaceuticals

Frequently Asked Questions

What are the most prescribed medications for axial spondyloarthritis?

Biologics such as IL-17 and TNF-α inhibitors are the top choice because they are effective in suppressing inflammation and halting disease progression.

Which firms are leading the development of axial spondyloarthritis treatments?

Novartis, AbbVie, and UCB are leaders with their IL-17 and IL-23 inhibitor therapies.

How do biologics differ from conventional treatments for the condition?

Biologics provide better results for moderate-to-severe cases, while NSAIDs are still first-line for initial-stage treatment.

What challenges do patients encounter in accessing these treatments?

Costs, insurance restrictions, and delayed diagnosis frequently restrict timely access to new therapies.

Are any new therapies nearing launch for this disease?

Next-generation IL-23 and dual-specific inhibitors are in late-stage testing with the potential to broaden treatment options.

Table of Content
  1. Executive Summary
  2. Market Overview
  3. Market Background
  4. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035
  5. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Types
    • Ankylosing Spondylitis Treatment
    • Non-radiographic
  6. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Drug Class
    • Non-steroidal anti-inflammatory drugs
    • Glucocorticoids
    • Anti-rheumatic drugs
  7. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By End User
    • Hospital
    • Clinics
    • Rehabilitation Centre
    • Academic Research Institutes
  8. Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Region
    • North America
    • Latin America
    • Europe
    • South Asia
    • East Asia
    • Oceania
    • MEA
  9. North America Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  10. Latin America Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  11. Europe Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  12. South Asia Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  13. East Asia Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  14. Oceania Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  15. MEA Market Analysis 2020 to 2024 and Forecast 2025 to 2035 By Country
  16. Key Countries Market Analysis
  17. Market Structure Analysis
  18. Competition Analysis
    • AbbVie
    • Pfizer
    • Amgen
    • Janssen Biotech
    • Pozen
    • Iroko Pharmaceuticals
    • Syntex Pharmaceuticals
    • Horizon Pharma
    • Eli Lilly and Company
    • Kyowa Kirin
    • Celgene
    • Inmagene Biopharmaceuticals
  19. Assumptions & Acronyms Used
  20. Research Methodology

Key Segmentation

By Types:

With respect to the types, it is classified into ankylosing spondylitis treatment and non-radiographic axial spondyloarthritis treatment.

By Drug Class:

In terms of drug class, it is divided into non-steroidal anti-inflammatory drugs, glucocorticoids, and anti-rheumatic drugs.

By End-User:

In terms of end-users, it is divided into hospitals, clinics, rehabilitation centres, and academic research institutes.

By Region:

In terms of region, it is segmented into North America, Latin America, Europe, East Asia, South Asia, Oceania, and MEA.

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